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Random, interesting studies

Literature Review
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  • M
    Mauritio
    last edited by Dec 28, 2024, 8:44 PM

    Caffeine Targets SIRT3 to Enhance SOD2 Activity in Mitochondria

    https://pmc.ncbi.nlm.nih.gov/articles/PMC7493682/

    Dare to think.

    My X:
    x.com/Metabolicmonstr

    1 Reply Last reply Reply Quote 0
    • M
      Mauritio
      last edited by Dec 29, 2024, 8:46 AM

      Sirt3 Deficiency Shortens Life Span and Impairs Cardiac Mitochondrial Function Rescued by Opa1 Gene Transfer

      https://pubmed.ncbi.nlm.nih.gov/31269804/

      Dare to think.

      My X:
      x.com/Metabolicmonstr

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      • M
        Mauritio
        last edited by Dec 29, 2024, 9:14 AM

        "SIRT3 reduced the expression of stearoyl-CoA desaturase 1..."

        https://pubmed.ncbi.nlm.nih.gov/31160717/

        Dare to think.

        My X:
        x.com/Metabolicmonstr

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        • M
          Mauritio
          last edited by Mauritio Dec 30, 2024, 11:26 AM Dec 29, 2024, 9:34 AM

          No study but isn't it interesting that
          Guggulsterone (C21H28O2) and
          Pregnenolone (C21H32O2) are almost the same molecules.
          That explains their similar effects.

          Z-Guggulsterone alleviates renal fibrosis by mitigating G2/M cycle arrest through Klotho/p53 signaling
          https://pubmed.ncbi.nlm.nih.gov/35123992/

          Dare to think.

          My X:
          x.com/Metabolicmonstr

          A 1 Reply Last reply Jan 2, 2025, 11:50 PM Reply Quote 0
          • A
            alfredoolivas @Mauritio
            last edited by Jan 2, 2025, 11:50 PM

            @Mauritio can you explain the similarities? cfcdd832-5a1e-4ec5-914d-39a26e32524b-image.png
            c1b75c3b-67ef-494c-ab1e-fc6b963adc47-image.png
            They seem very different in their structure to me

            M 1 Reply Last reply Jan 3, 2025, 5:17 PM Reply Quote 0
            • M
              Mauritio @alfredoolivas
              last edited by Jan 3, 2025, 5:17 PM

              @alfredoolivas The backbone is very similar not sure how to explain that to you

              Dare to think.

              My X:
              x.com/Metabolicmonstr

              1 Reply Last reply Reply Quote 0
              • M
                Mauritio
                last edited by Mauritio Jan 3, 2025, 8:00 PM Jan 3, 2025, 7:59 PM

                High salt diet induces muscle loss via cortisol, if simultaneously given saline Solution, not if rats were given tap water.Maybe there's a Sweet Spot for Salt.
                https://pmc.ncbi.nlm.nih.gov/articles/PMC5409074/

                Dare to think.

                My X:
                x.com/Metabolicmonstr

                B 1 Reply Last reply Jan 3, 2025, 11:56 PM Reply Quote 0
                • B
                  bot-mod @Mauritio
                  last edited by Jan 3, 2025, 11:56 PM

                  A sweet spot, a circadian and an infradian. I'll be lucky if I can get there a few times a week because it's a moving target. Unless I do nothing, say nothing, go nowhere and see no one.

                  1 Reply Last reply Reply Quote 0
                  • M
                    Mauritio
                    last edited by Mauritio Jan 4, 2025, 10:34 AM Jan 4, 2025, 10:34 AM

                    Dates (polyphenols) activate FXR and modulate bile acids.
                    https://pmc.ncbi.nlm.nih.gov/articles/PMC5749773/

                    Dare to think.

                    My X:
                    x.com/Metabolicmonstr

                    1 Reply Last reply Reply Quote 0
                    • M
                      Mauritio
                      last edited by Mauritio Jan 5, 2025, 2:38 PM Jan 5, 2025, 2:10 PM

                      Chlorogenic Acid Inhibits Lipid Deposition by Regulating the Enterohepatic FXR-FGF15 Pathway
                      https://pubmed.ncbi.nlm.nih.gov/35257010/

                      Chlorogenic acid fed mice increase less in weight than controls mice on a high fat diet. AND weigh less than animals on a normal control diet.
                      https://pubmed.ncbi.nlm.nih.gov/20064576/

                      Might inhibit Mao a+b
                      https://pubmed.ncbi.nlm.nih.gov/29893510/

                      Dare to think.

                      My X:
                      x.com/Metabolicmonstr

                      1 Reply Last reply Reply Quote 0
                      • D
                        dapose
                        last edited by Jan 6, 2025, 4:42 PM

                        I like this thread.
                        Thank you

                        M 1 Reply Last reply Jan 6, 2025, 6:45 PM Reply Quote 0
                        • M
                          Mauritio @dapose
                          last edited by Jan 6, 2025, 6:45 PM

                          @dapose you're welcome.

                          Dare to think.

                          My X:
                          x.com/Metabolicmonstr

                          1 Reply Last reply Reply Quote 0
                          • M
                            Mauritio
                            last edited by Mauritio Jan 11, 2025, 12:11 PM Jan 11, 2025, 11:57 AM

                            Magnesium Sulphate for "stuck bile" I cholestasis

                            "Taken together, the results of this study suggest that MgSO4 treatment may be beneficial in cholestasis-induced hepatotoxicity."
                            https://pubmed.ncbi.nlm.nih.gov/25967882/

                            "Mg SO4 may increase bile secretion and relax the sphincter Of Oddi, resulting in emptying and consequently a reduction of Gallbladder volume"
                            https://journals.lww.com/ajg/fulltext/2004/10001/the_effect_of_magnesium_sulfate_on_the_human.140.aspx

                            It increases the discharge of bile
                            https://pubmed.ncbi.nlm.nih.gov/955499/

                            i was thinking maybe topical application of magnesium sulfate to relax the sphincter of oddi muscle and to increase bile discharge.

                            596da1a1-f0b2-4029-a67d-be7ee3b0cd11-17365973310072473217368389128298.jpg

                            Dare to think.

                            My X:
                            x.com/Metabolicmonstr

                            1 Reply Last reply Reply Quote 0
                            • M
                              Mauritio
                              last edited by Mauritio Jan 18, 2025, 3:20 PM Jan 18, 2025, 9:07 AM

                              3,8-Dihydrodiligustilide
                              Strong phytoprogestogen.
                              https://en.m.wikipedia.org/wiki/3,8-Dihydrodiligustilide

                              It has almost the same potency as progesterone (80% of it). And it has no estrogenic or anti-androgenic effects.

                              "EtOH extracts of the dried rhizome of L. chuanxiong demonstrated strongest
                              progestogenic activity, reaching 80% of that observed with progesterone (100 nM) and had an EC50 of 8 lg/ml (Fig. 1b). The bioactivity of L. chuanxiong extract was spe-
                              cific to the PR, and the extract was at least 200-fold less active on other related members of the steroid receptor family like androgen, estrogen and glucocorticoid receptors."

                              https://www.sci-hub.wf/10.1016/j.phytochem.2006.01.024

                              Dare to think.

                              My X:
                              x.com/Metabolicmonstr

                              M 1 Reply Last reply Jan 18, 2025, 3:45 PM Reply Quote 0
                              • M
                                Mauritio
                                last edited by Mauritio Feb 2, 2025, 11:47 AM Jan 18, 2025, 9:20 AM

                                EDIT: Bloodroot might bin very well to the progesterone receptor but not agonize it.

                                1000012196.png 1000012198.png 1000012200.png

                                https://journals.sagepub.com/doi/abs/10.3181/00379727-217-44247

                                Dare to think.

                                My X:
                                x.com/Metabolicmonstr

                                1 Reply Last reply Reply Quote 0
                                • M
                                  Mauritio
                                  last edited by Jan 18, 2025, 9:45 AM

                                  Dates, olives and walnuts contain the highest amounts of the phytoprogestogen syringic acid.

                                  http://phenol-explorer.eu/contents/polyphenol/420

                                  https://pubmed.ncbi.nlm.nih.gov/9704030/

                                  Dare to think.

                                  My X:
                                  x.com/Metabolicmonstr

                                  M 1 Reply Last reply Jan 31, 2025, 4:34 PM Reply Quote 0
                                  • M
                                    Mauritio @Mauritio
                                    last edited by Jan 18, 2025, 3:45 PM

                                    @Mauritio said in Random, interesting studies:

                                    3,8-Dihydrodiligustilide
                                    Strong phytoprogestogen.
                                    https://en.m.wikipedia.org/wiki/3,8-Dihydrodiligustilide

                                    It has almost the same potency as progesterone (80% of it). And it has no estrogenic or anti-androgenic effects.

                                    "EtOH extracts of the dried rhizome of L. chuanxiong demonstrated strongest
                                    progestogenic activity, reaching 80% of that observed with progesterone (100 nM) and had an EC50 of 8 lg/ml (Fig. 1b). The bioactivity of L. chuanxiong extract was spe-
                                    cific to the PR, and the extract was at least 200-fold less active on other related members of the steroid receptor family like androgen, estrogen and glucocorticoid receptors."

                                    https://www.sci-hub.wf/10.1016/j.phytochem.2006.01.024

                                    The plant Ligusticum sinense chuanxiong from which it is extracted is traditionally used to treat uterus issues. It also has been studied to treat strokes and Parkinson's.

                                    In this review they look at the anti inflammatory effect of it.

                                    https://pmc.ncbi.nlm.nih.gov/articles/PMC7591981/

                                    Dare to think.

                                    My X:
                                    x.com/Metabolicmonstr

                                    M 1 Reply Last reply Jan 23, 2025, 9:42 AM Reply Quote 0
                                    • M
                                      Mauritio @Mauritio
                                      last edited by Mauritio Jan 25, 2025, 10:12 AM Jan 23, 2025, 9:42 AM

                                      @Mauritio said in Random, interesting studies:

                                      @Mauritio said in Random, interesting studies:

                                      3,8-Dihydrodiligustilide
                                      Strong phytoprogestogen.
                                      https://en.m.wikipedia.org/wiki/3,8-Dihydrodiligustilide

                                      It has almost the same potency as progesterone (80% of it). And it has no estrogenic or anti-androgenic effects.

                                      "EtOH extracts of the dried rhizome of L. chuanxiong demonstrated strongest
                                      progestogenic activity, reaching 80% of that observed with progesterone (100 nM) and had an EC50 of 8 lg/ml (Fig. 1b). The bioactivity of L. chuanxiong extract was spe-
                                      cific to the PR, and the extract was at least 200-fold less active on other related members of the steroid receptor family like androgen, estrogen and glucocorticoid receptors."

                                      https://www.sci-hub.wf/10.1016/j.phytochem.2006.01.024

                                      The plant Ligusticum sinense chuanxiong from which it is extracted is traditionally used to treat uterus issues. It also has been studied to treat strokes and Parkinson's.

                                      In this review they look at the anti inflammatory effect of it.

                                      https://pmc.ncbi.nlm.nih.gov/articles/PMC7591981/

                                      HED about 20g of the extract.
                                      "Effect-time studies indicate that injection of MPA and L. chuanxiong extract raised area-under-curve of progestogenic activity in sera by 8.2-fold (p<0.001) and 4.5-fold (p<0.01) respectively, compared to sera from rats administered vehicle only. Administration of MPA and L. chuanxiong extract by the oral route resulted in a 5.4 (p<0.001) and 2.3-fold (p=0.07) increase respectively. Our data suggest that PR-responsive reporter gene bioassays can measure bioavailability of compounds, known and unknown, of complex botanicals for hormone replacement therapy. L. chuanxiong extracts exert progestogenic activity in vivo, and may have utility for progesterone-replacement therapy."

                                      https://pubmed.ncbi.nlm.nih.gov/16650443/

                                      good review on it
                                      https://www.tandfonline.com/doi/full/10.3109/13880209.2011.576346#d1e665

                                      HED = 850mg of the extract.
                                      L. Chuanxiong completely prevented weight gain on a high fat diet. It increases antioxidants and cholesterol conversion into bile acids. Genes related to steroid biosynthesis were also upregulated so I guess that was another way it lowered cholesterol.
                                      https://iadns.onlinelibrary.wiley.com/doi/full/10.1002/fft2.249

                                      Protective Effect of SFE-CO2 of Ligusticum chuanxiong Hort Against d-Galactose-Induced Injury in the Mouse Liver and Kidney
                                      https://pubmed.ncbi.nlm.nih.gov/28056664/

                                      Chuanxiong Rhizoma extracts prevent cholestatic liver injury by targeting H3K9ac-mediated
                                      https://pubmed.ncbi.nlm.nih.gov/37777319/

                                      Chuanxiong Rhizoma extracts prevent liver fibrosis via targeting CTCF-c-MYC-H19 pathway
                                      https://pubmed.ncbi.nlm.nih.gov/38375042/

                                      Dare to think.

                                      My X:
                                      x.com/Metabolicmonstr

                                      1 Reply Last reply Reply Quote 0
                                      • M
                                        Mauritio
                                        last edited by Mauritio Jan 26, 2025, 12:23 PM Jan 26, 2025, 11:40 AM

                                        "PO [Peppermint oil ]significantly promoted bile and bile acid secretion in rats. It also increased bile acid efflux and decreased cholesterol levels (Pā€ƒ<ā€ƒ0.01) in bile. In HepG2 cells the mRNA levels of CYP7A1 and FXR were significantly upregulated after treatment with PO."
                                        https://onlinelibrary.wiley.com/doi/full/10.1111/j.1751-2980.2011.00513.x?utm_source=chatgpt.com

                                        Menthol + Menthone seem to have a dopaminergic effect
                                        https://pubmed.ncbi.nlm.nih.gov/18718482-/
                                        https://pubmed.ncbi.nlm.nih.gov/12686756/

                                        Menthol has some overlapping effects with progesterone as per this study
                                        https://pubmed.ncbi.nlm.nih.gov/13819868/
                                        It also acts as an anaesthetic like progesterone
                                        https://pubmed.ncbi.nlm.nih.gov/11301871/

                                        Mode of action of peppermint oil and (-)-menthol with respect to 5-HT3 receptor
                                        https://pubmed.ncbi.nlm.nih.gov/21077259/

                                        "...menthol acts as a noncompetitive antagonist of the 5-HT3 receptor..."
                                        https://pubmed.ncbi.nlm.nih.gov/23965380/

                                        Menthol decreased milk production ,which hints at an anti prolactin effect and it inhibits mTOR.
                                        https://pubmed.ncbi.nlm.nih.gov/33188562/

                                        Anti-leukemic effect of menthol, a peppermint compound, on induction of apoptosis and autophagy
                                        https://pubmed.ncbi.nlm.nih.gov/36923503/

                                        I'd say given these studies, it's worth to try peppermint oil, which can consist of up to 80% menthol + Menthone.

                                        Dare to think.

                                        My X:
                                        x.com/Metabolicmonstr

                                        A 1 Reply Last reply Jan 26, 2025, 11:52 AM Reply Quote 0
                                        • A
                                          alfredoolivas @Mauritio
                                          last edited by alfredoolivas Jan 26, 2025, 11:52 AM Jan 26, 2025, 11:52 AM

                                          @Mauritio Menthol, Camphor, Menthone and Eucalyptus, all are terpenoids known for their "cooling" effect, and are completely saturated- Camphor and Eucalyptus are even saturated cages, similar to Adamantane. Very interesting to me.
                                          I would love to see if their is some overlap in their origin, structure or effects

                                          M 1 Reply Last reply Jan 26, 2025, 11:55 AM Reply Quote 0
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