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Diclofenac gel to regrow hair on bald head and beard

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  • H
    Hearthfire @wester130
    last edited by Jan 8, 2025, 6:52 PM

    @wester130 Powerful anti-inflammatory action. Whatever is going on in the scalp that causes the inflammation, it reduces that inflammation effectively, and allows hair to grow again. Could be the lowering of pgd2.

    This post from a thread on hairlosstalk seems to hit the nail on the head

    If you look at the mechanism of action, it inhibits cox as most NSAIDs. Means it lowers also the beneficial pge1, pge2 and pgf2a. However bald scalp mostly expresses pgd2 and low pge2, makes sense that there is overall a beneficial effect. Story changes probably once you want actual regrowth, and are already taking finasteride/dutasteride/ru etc and also start more targeting of that pathway (crth2 inhibitors, pge2, pgf2a analogues...). I guess one could in fact try diclo plus topical pge analgues (you probably at least want pge2 analogue plus castor oil and in addition some potent pgf2a like chloprostenol) to avoid this issue and save some money on seti etc (and avoid the non-responder issue with crth2i therapy). I also would avoid diclo while woundling, as inflammation triggers the growthfactors which makes it even less practical as pgd2 and crth2 inhibit wound induced hf neogenesis.

    https://www.hairlosstalk.com/interact/threads/diclofenac-now-available-over-the-counter.127444/post-1874753

    I bet pairing it with castor oil taken orally would be a powerful combination.

    The ricinoleic acid in castor oil is a potent pge2 agonist, it stimulates pge2, and potentially has an antagonizing effect with pgd2. Pge2 promotes relaxtion of tissues, pgd2 promotes constriction of tissues.
    Good video from More Plates More Dates on the subject:
    Youtube Video

    So you lower the high balding scalp levels of pgd2 with the Diclofenac gel, then take castor oil to promote pge2, and get even more pgd2 antagonist action.

    W M 2 Replies Last reply Jan 8, 2025, 7:38 PM Reply Quote 0
    • W
      wester130 @Hearthfire
      last edited by Jan 8, 2025, 7:38 PM

      @Hearthfire it still sounds a dangerous drug

      I am consdiering NMN, nicotinamide mononucleotide, seems better than niacinamide

      H 1 Reply Last reply Jan 8, 2025, 8:00 PM Reply Quote 0
      • H
        Hearthfire @wester130
        last edited by Hearthfire Jan 8, 2025, 8:01 PM Jan 8, 2025, 8:00 PM

        @wester130

        I did a bit more reading on the side effects, the crazy stuff like heart attacks seems it's related to people taking it in tablet form in fairly high doses, and it's because it raises your blood pressure.

        I don't think rubbing the gel on topically would cause an issue, not anymore than nizoral/minoxidil and some of the other things people use topically. Since you can now buy the gel on freakin' Amazon without a prescription, I imagine it's very safe to use topically.

        People take NSAIDs all the time that increase the risk of heart attack. Doesn't mean it will. If you're not healthy, by all means avoid it.

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        • M
          Mossy
          last edited by Jan 9, 2025, 10:48 PM

          @Hearthfire @wester130
          It will be good to hear how you guys do on it. Definitely interested to know if you get any sides, with heart and stomach. Too bad that Hairlosstalk forum poster never reported back.

          "To desire action is to desire limitation" — G. K. Chesterton
          "The true step of health and improvement is slow." — Novalis

          1 Reply Last reply Reply Quote 0
          • M
            Mossy @wester130
            last edited by Jan 9, 2025, 10:50 PM

            @wester130 said in Diclofenac gel to regrow hair on bald head and beard:

            I may try voltarol gel instead

            Interesting. You're thinking the non-generic may be more pure, therefore less sides?

            "To desire action is to desire limitation" — G. K. Chesterton
            "The true step of health and improvement is slow." — Novalis

            W 3 Replies Last reply Jan 9, 2025, 11:17 PM Reply Quote 0
            • M
              Mossy @Hearthfire
              last edited by Jan 9, 2025, 10:53 PM

              @Hearthfire said in Diclofenac gel to regrow hair on bald head and beard:

              I also would avoid diclo while woundling, as inflammation triggers the growthfactors which makes it even less practical as pgd2 and crth2 inhibit wound induced hf neogenesis.

              If true, this is good information to have.

              "To desire action is to desire limitation" — G. K. Chesterton
              "The true step of health and improvement is slow." — Novalis

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              • W
                wester130 @Mossy
                last edited by Jan 9, 2025, 11:17 PM

                @Mossy possibly less sides, also need to be aware of a strange dry cough it can cause

                1 Reply Last reply Reply Quote 0
                • B
                  BearWithMe @Mossy
                  last edited by Jan 11, 2025, 3:40 PM

                  @Mossy said in Diclofenac gel to regrow hair on bald head and beard:

                  After some additional research, I'm going to have to count out taking Diclofenac gel for now, based on potential severe stomach issues, such as ulcers and deterioration of the lining.

                  If I understand these posts correctly, some users of Diclofenac take an additional supplement or drug to counter the lining deterioration, ulcer issue. That seems like a tightrope that would be hard to walk, getting the balance just right. At least for someone highly susceptible to side effects.

                  https://www.reddit.com/r/ChronicPain/comments/bn7a7z/comment/en3g3zc/

                  Please correct me if I'm worng. I think these side effects are somewhat common when oral Diclofenac is used, but super super rare when it is applied topically? European drug regulatory agencies doesn't seem to list any such effects, only local irritation / skin-related side effects, and possible allergic reactions (asthma, swelling, very rare, less than 1 report in 10 000), nothing else. Anecdotal evidence seems to support that.

                  But obviously, with drug / supplement sensitivity you described, one never knows

                  H M 2 Replies Last reply Jan 11, 2025, 4:07 PM Reply Quote 0
                  • H
                    Hearthfire @BearWithMe
                    last edited by Jan 11, 2025, 4:07 PM

                    @BearWithMe

                    Yeah, I did a little reading into it, it seems to be from oral pills at moderate to high doses.

                    Other NSAIDs people take have similar side effects, but millions of people take them every day without issue.

                    I think topical is probably safe.

                    1 Reply Last reply Reply Quote 0
                    • W
                      wester130 @Mossy
                      last edited by Jan 11, 2025, 5:25 PM

                      @Mossy you should still take caution but this says topical is safer

                      https://pmc.ncbi.nlm.nih.gov/articles/PMC5721772/

                      M 1 Reply Last reply Jan 13, 2025, 5:35 AM Reply Quote 0
                      • M
                        Mossy @BearWithMe
                        last edited by Jan 13, 2025, 5:34 AM

                        @BearWithMe said in Diclofenac gel to regrow hair on bald head and beard:

                        @Mossy said in Diclofenac gel to regrow hair on bald head and beard:

                        After some additional research, I'm going to have to count out taking Diclofenac gel for now, based on potential severe stomach issues, such as ulcers and deterioration of the lining.

                        If I understand these posts correctly, some users of Diclofenac take an additional supplement or drug to counter the lining deterioration, ulcer issue. That seems like a tightrope that would be hard to walk, getting the balance just right. At least for someone highly susceptible to side effects.

                        https://www.reddit.com/r/ChronicPain/comments/bn7a7z/comment/en3g3zc/

                        Please correct me if I'm worng. I think these side effects are somewhat common when oral Diclofenac is used, but super super rare when it is applied topically? European drug regulatory agencies doesn't seem to list any such effects, only local irritation / skin-related side effects, and possible allergic reactions (asthma, swelling, very rare, less than 1 report in 10 000), nothing else. Anecdotal evidence seems to support that.

                        But obviously, with drug / supplement sensitivity you described, one never knows

                        Thank you for pointing that out. I came back here to say something to that exact point, but you beat me to it. It does seem like those effects are from oral, not topical. But I can tell you that I'm about 95% sure I'll still get them from topical, albeit not as strong. I can't even use topical niacin or niacinamide without negative effects, e.g., allergic reactions: over all malaise, hypoxia-like breathing issues, . Even so, I do have some Diclofenac in my cart on Amazon! I am mulling over whether the name brand would offer a higher quality product, and therefore less sides, as @wester130 was considering.

                        "To desire action is to desire limitation" — G. K. Chesterton
                        "The true step of health and improvement is slow." — Novalis

                        1 Reply Last reply Reply Quote 0
                        • M
                          Mossy @wester130
                          last edited by Mossy Jan 13, 2025, 5:36 AM Jan 13, 2025, 5:35 AM

                          @wester130 said in Diclofenac gel to regrow hair on bald head and beard:

                          @Mossy you should still take caution but this says topical is safer

                          https://pmc.ncbi.nlm.nih.gov/articles/PMC5721772/

                          Indeed. Thank you for bringing that up. I would start very slowly.

                          "To desire action is to desire limitation" — G. K. Chesterton
                          "The true step of health and improvement is slow." — Novalis

                          B 1 Reply Last reply Jan 13, 2025, 6:03 AM Reply Quote 0
                          • B
                            BearWithMe @Mossy
                            last edited by BearWithMe Jan 13, 2025, 6:05 AM Jan 13, 2025, 6:03 AM

                            @Mossy Be careful not to cause the side effects just by expecting the side effects. Wish you the best of luck.

                            It is very interesting that Diclofenac is apparently effective for both hair loss and beard loss. The pathology of the two seems to be very different, almost the opposite?

                            M 1 Reply Last reply Jan 13, 2025, 7:25 AM Reply Quote 0
                            • M
                              Mossy @BearWithMe
                              last edited by Jan 13, 2025, 7:25 AM

                              @BearWithMe said in Diclofenac gel to regrow hair on bald head and beard:

                              @Mossy Be careful not to cause the side effects just by expecting the side effects. Wish you the best of luck.

                              It is very interesting that Diclofenac is apparently effective for both hair loss and beard loss. The pathology of the two seems to be very different, almost the opposite?

                              I get that. A self-fulfilling prophecy. I am conscious of that. And thank you!

                              I have read many stories of people successfully using minoxidil for beard growth. So, maybe not that different after all.

                              "To desire action is to desire limitation" — G. K. Chesterton
                              "The true step of health and improvement is slow." — Novalis

                              O 1 Reply Last reply Jan 13, 2025, 4:36 PM Reply Quote 0
                              • O
                                onliest @Mossy
                                last edited by Jan 13, 2025, 4:36 PM

                                @Mossy what about GHK-cu dissolved in DMSO?

                                W M 2 Replies Last reply Jan 13, 2025, 4:47 PM Reply Quote 0
                                • W
                                  wester130 @onliest
                                  last edited by Jan 13, 2025, 4:47 PM

                                  @onliest are you referring to a zinc thymullin product?

                                  https://infiniwell.com/products/duo-cosmetic-ghk-cu-zu-thymulin

                                  O 1 Reply Last reply Jan 13, 2025, 5:03 PM Reply Quote 0
                                  • O
                                    onliest @wester130
                                    last edited by Jan 13, 2025, 5:03 PM

                                    @wester130 No but that product is interesting. I've made a serum with ghk-cu with vegetable glycerin as a base to use on my face. I think with DMSO as a base would increase absorbability. I have plenty of hair but a few white ones, and flaky scalp, I think from fungus.

                                    W 1 Reply Last reply Jan 13, 2025, 6:32 PM Reply Quote 0
                                    • W
                                      wester130 @onliest
                                      last edited by Jan 13, 2025, 6:32 PM

                                      @onliest what are you trying to achieve? regrowth?? you could dissolve 100mg of caffeine in it and it would be a perfect product

                                      O 1 Reply Last reply Jan 13, 2025, 6:43 PM Reply Quote 0
                                      • O
                                        onliest @wester130
                                        last edited by Jan 13, 2025, 6:43 PM

                                        @wester130 Maybe I'll mix some bloo in too. I don't know where to find zinc-thymulin. I think I have some measure of chronic seb derm. Bloo helps but it comes back. Probably secondary to poor scalp perfusion/low thyroid function. I'd like to blast T3 again but I get fat.

                                        1 Reply Last reply Reply Quote 0
                                        • M
                                          Mossy @onliest
                                          last edited by Jan 14, 2025, 6:03 AM

                                          @onliest said in Diclofenac gel to regrow hair on bald head and beard:

                                          @Mossy what about GHK-cu dissolved in DMSO?

                                          GHK-cu is on my very long list of things to try (again). You may have read I did try copper peptides about 15 years ago, for about a 6 month stint. I do feel that it helped with hair color and maybe even retaining hair, but there is no way for me to tell for sure. But, during that time I also declined into the worst health state of my life. I can't necessarily blame copper peptides, because my life was very stressful at that time as well. I'm more apt to blame the stress than supplements. But, ever since that health decline I've never been the same. I can't take supplements like I used to.

                                          Purely from a cost and convenience perspective, I'm more apt to try Diclofenac than more expensive options, such as GHK-cu. If it weren't for the potential sides I would jump right in.

                                          "To desire action is to desire limitation" — G. K. Chesterton
                                          "The true step of health and improvement is slow." — Novalis

                                          O 1 Reply Last reply Jan 14, 2025, 1:48 PM Reply Quote 0
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