DHT as an alternative for TRT
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I wonder if it’s possible that just pregnenelone, thyroid, and dhea could get me from 15ng/dL to a good healthy T level ?
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@ooopilled Yes, androsterone is an AI and converts to DHT. I think 3-4mg inhibited aromatase by 90%. @haidut had favorable lab results posted on the RP forum by using transdermal Andro in ethanol. I would assume that oral dissolved in tocopherols would work too, though
In time there is life but no knowledge; outside time there is knowledge but no life
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@sushi_is_cringe Sounds like a W for DHT
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Proviron Summary of Product Characteristics
Looks like it's still being manufactured and is used in the middle east.
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@ooopilled Deca is highly suppressive but I don't think it would affect 5AR. Given your test levels are very low I don't think there's any reason to think 5AR is affected. If for example you had normal T but low DHT symptoms then there might be some reason to suspect a problem with 5AR
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@jamezb46 said in DHT as an alternative for TRT:
@ooopilled Yes, androsterone is an AI and converts to DHT. I think 3-4mg inhibited aromatase by 90%.
Quite interesting, will check out!
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Have you tried pct? To my understanding there are bodybuilders that blast T for a decade and then get off it using clomid or other such drugs, and their T levels are only slightly affected. This may be useful for getting to a reasonable baseline for endogenous production for t.
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@jamezb46 Thanks
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@ooopilled said in DHT as an alternative for TRT:
I wonder if it’s possible that just pregnenelone, thyroid, and dhea could get me from 15ng/dL to a good healthy T level ?
thoughts? @jamezb46
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Well, I think we need to keep in mind that Ray was probably talking about oral or transdermal testosterone, not injectable.
But, ya you could also try the idea labs product Pansterone orally or transdermally. People have reported it boosted their T levels.
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@jamezb46 Also if im not mistaken the T boost from pansterone would be most likely from the DHEA rather than the pregnenolone, while pregnenolone seems to metabolize into progesterone more than anything? Ive also heard from Hans that DHEA boosts T in a very dose dependent matter (i.e. 50mg can give you a 25-50ng/dl boost, 100mg can give you a 100ng/dl boost, 200mg can give you a 200ng/dl boost. etc) but iirc those high doses would be very estrogenic and Ray Peat recommended doses under 15mg.
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@jamezb46 Do you think proviron alone could act as “testosterone replacement” in my case or would I still need to pair it with standard TRT since my baseline levels are so low?
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@ooopilled Lets say I did 25mg proviron + 15mg pansterone. Could this be comparable to a standard TRT dose of 150-250mg test or would it not compare?
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@ooopilled It likely wouldn't compare, according to this study:
https://link.springer.com/article/10.1007/BF03348281
A group was given 120mg of testosterone undecanoate daily orally. Note that oral testosterone undecanoate, has a half life of a few hours, due to first pass metabolism. It does not build up in the system, and has a much shorter half life than proviron (12-13 hours),
Another group was given 150mg of mesterolone (Proviron) daily, and the effects were compared.TU is the testosterone undecanoate group & mesterolone is the Proviron group
"The effects seen for TU on these variables are much better than those observed for M. The low activity 01 M found in this study is in agreement with observations by other authors (10 - 12) and by ourselves (Franchi unpublished data). In view 01 this low activity we decided to use a considerably higher daily dose of M than that recommended. "
Proviron does seem to bring strong mental benefits; a study showed it was as effective as SSRIs in treating depression. However, this is likely due to neurosteroid metabolites, and not due to Proviron being a decent androgen. In the end, Proviron does not shut down the HPG axis, and this is a clear sign that it does not considerably agonise the androgen receptor in humans
Furthermore, as James pointed out, Proviron is only available as a pharmaceutical in the middle east, such as Omar and Kuwait. Any "Proviron" currently sold by vendors, are guaranteed to be counterfeit, as it is not even produced in Turkey or anyother country anymore, and it is a very rare medication to be prescribed. This is verified by personal experience as well, as the Proviron I received from Turkey, were revealed to be counterfeit when I scanned their QR code on the Turkish medicine verification app.
Therefore, proviron has the disadvantage of only being available from underground labs, if you want a drug you can trust is real, use TRT as you can get that prescribed in the US.
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@alfredoolivas apparently dbol doesnt shut down lh fsh to a high degree on a cycle yet it is quite anabolic so what say you then
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@sushi_is_cringe I doubt that. Which study and what doses were used? The doses used medically tend to be quite low. With Mesterolone / Proviron, the medical community actually noticed it's lack of effectiveness, and that's why studies were performed with doses mesterolone, up to 150mg a day, as they were trying to push it's limits. Even with these 100mg+ doses, it seemed to be non-supressive in most people. With the regular 25-50mg doses? Unsuppresive for all patients.
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I have the study.
"Anabolic" effects of methandienone in men undergoing athletic training
G.R Hervey October 1976, Published in The Lancet
100 mg Dbol per diem for 6 weeks. LH, FSH had no statistically significant decline, but testosterone fell by about half. That suggests that there is primary transient hypogonadism because there is enough LH, FSH in the blood but the testicles are not producing enough testosterone. That leads me to think that there is some negative feedback directly in the testicles.
It could also be that there is excessive conversion to estrogen, but I think the testicles are also being inhibited.
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@jamezb46 Very interesting. Yes, the testicles will reduce their expression of crucial steroidogenic enzymes, in response to more androgen agonism in the testicles.
https://sci-hub.se/10.1111/j.1749-6632.1984.tb38367.x
As seen on the graph, R1881 / Methyltrenbolone, was able to reduce hCG stimulated expression of intratesticular 3-beta HSD levels.Estradiol also does the same
https://pubmed.ncbi.nlm.nih.gov/3862577/@jamezb46 said in DHT as an alternative for TRT:
@alfredoolivas
It could also be that there is excessive conversion to estrogen, but I think the testicles are also being inhibited.Generally, a minuscule amount of androgens are converted into estrogen. Testosterone is roughly 200–1,000 times higher than estradiol in concentration.
That is why androgens are measured in ng/dl, whereas estrogen is measured in pg/dl.
So it's impossible for testosterone to be significantly lowered, due to aromatase "stealing it" and turning it into estrogen. Estrogen will only lower testosterone by inhibiting LH and lowering steroidogenic enzymes. And it does so very well
