Aspirin for Bipolar (or other mood issues)

xx

I started taking aspirin in a depressive state of despair after recovering from a manic period that resulted in psychosis. I didn't want to take the prescribed anti-psychotics due to my horrible experiences with them in the past.

So far, I've experienced a significant stabilization of my mood and easier ability to manage feelings of guilt and shame (these feelings are almost gone now 2 weeks~ later).

I highly recommend experimenting with aspirin if you haven't and are struggling with a mood-related issue.

I take about 325-500mg in separated doses daily, but it seems that even lower doses could be viable.

I'm not entirely sure on the means in which the results occur from, but it's possibly inflammation related based on the small bits I've read... there may be more information than these articles out there, but this is what I found if it interests you:
https://pmc.ncbi.nlm.nih.gov/articles/PMC6895819/
https://pmc.ncbi.nlm.nih.gov/articles/PMC11575337/
https://pubmed.ncbi.nlm.nih.gov/31379619/

I'm interested in hearing about other stories or studies any of you may have.

DavidPS

@xx - Welcome to the forum.

@xx said in Aspirin for Bipolar (or other mood issues):

I take about 325-500mg in separated doses daily, but it seems that even lower doses could be viable.

I am not clear about your total daily amount of aspirin. Dr. Peat recommended taking Vitamin K to protect against bleeding and other effects of prolonged aspirin use.
see https://raypeatemails.com/Topics/Aspirin

Other anti-inflammatories that might be useful to consider:

Peatbot.com: Based on the provided context, some safe anti-inflammatory substances and supplements include:

Aspirin: Known for its anti-inflammatory properties and ability to potentiate the deacetylation of histones.

Magnesium: Helps stabilize mast cells and reduce the release of histamine, which promotes inflammation.

Caffeine: Found in coffee and chocolate, it has anti-inflammatory and liver-protective effects.

Coconut Oil: Contains saturated fatty acids that inhibit histamine formation and protect the liver from endotoxin.

Progesterone and Testosterone: These hormones protect against histamine.

Benadryl (Diphenhydramine): Protects the liver and other organs from toxins and the effects of histamine.

Thyroid Hormone: Known for its anti-inflammatory function, especially in arthritis and rheumatic conditions.

Carbon Dioxide (CO2): Described as a basic anti-inflammatory substance.

Methylene Blue: Effective in small doses as an anti-inflammatory agent.

Saturated Fats: Found in foods like coconut oil, they have protective, anti-inflammatory effects.

These substances are noted for their anti-inflammatory properties and are considered safe when used appropriately. However, it's important to consult with a healthcare provider before starting any new supplement regimen.

DavidPS

Incidentally, aspirin was projected over 10 years ago to cost pension systems lots of money.

Aspirin seen costing pensions $100 billion as lifespans increase

I find the bean counters to be more convincing than the medical establishment on the net benefits of taking aspirin. Aspirin has got to be healthy for individuals.

@LetTheRedeemed

LetTheRedeemed

@DavidPS hahaha that’s awesome. Yes agreed… thanks for the share

jamezb46

@DavidPS Pregnenalone as well

xx

@DavidPS

Thanks for the welcome!

I'm surprised to learn that CO2 is anti-inflammatory, even having been familiar with some of its other great properties.

The pension article is absolutely wild.

@DavidPS said in Aspirin for Bipolar (or other mood issues):

I am not clear about your total daily amount of aspirin. Dr. Peat recommended taking Vitamin K to protect against bleeding and other effects of prolonged aspirin use.

From what I have researched, it seems that 1mg of K2 per every 325mg of Aspirin seems to be the recommendation, does that sound correct?

GlucoseGal

This is really interesting as I struggled with bipolar for many years before starting Thyroid supplementation, specifically T3. I’m wanting to come off it as I’ve gained weight on it and feel it’s stressing my adrenals. I’m going to look into to Aspirin, thank you!

DavidPS

@xx - I have read different opinions on how much K2 is sufficient. You might consider tracking your diet for a few days using something like chronometer.com to determine if you need to supplement.

LetTheRedeemed

@GlucoseGal it shouldn’t be stressing your adrenals unless your cholesterol is too low

GlucoseGal

@LetTheRedeemed Before starting T3 my blood results showed high cholesterol. Interesting point as I responded well for a while. Perhaps my cholesterol levels have come down.

LetTheRedeemed

@GlucoseGal interesting. I learned from a group chat with Danny that it can be a little difficult and also very important, to maintain ~~high~~ adequate cholesterol.

An egg yolk a day should give you a huge amount of cholesterol, but you may still need higher sugar sources (like juice) to maintain adequately high cholesterol throughout the day. Don’t ask me why it just works — it was a Peat concept.

Something other Peaty therapists have noted is that people often just don’t eat enough on thyroid.

GlucoseGal

@LetTheRedeemed Thanks for your reply, good points there. I’m definitely under eating, I don’t want more weight gain.

LetTheRedeemed

@GlucoseGal I know I’ve been there too, but also take it from me, that when on proper thyroid meds and their amounts, it’s harder to gain weight — definitely begin first checking on temps and pulse before gobbling down more food. It may be something as simple as more palatable foods — more salt to enhance flavored dishes comes to mind. And, aside from the egg yolk and a couple teaspoons of butter/coconut oil a day, you can always dial down fat intake to prevent weight gain.

GlucoseGal

@LetTheRedeemed that’s what’s surprising about all this, people take T3 for weight loss a lot of the time. I really appreciate your help, thank you. Starting with checking my temps like you’ve suggested.

LetTheRedeemed

@GlucoseGal of course, wish you the best. Honestly, I wonder if a lot of people who come to the Peat space take baggage from past dietary ideas with them — my insistence on fat for satiety from my carnivore days definitely contributed to weight gain — but if I had just put less butter in my rice and ate more rice and less chocolate, I don’t think I’d have gained 40 lbs Peating — and of course I got on actual thyroid meds (not glandulars) well after the weight gain.