Chris Masterjohn: Salicylates are Toxic
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@Korven said:
But in healthy people, taking 25-OH-D3 should (at least in theory) lower PTH levels which then reduces the synthesis of calcitriol in the kidneys. So in the short-term vitamin D3 increases calcitriol, but in the long-term it lowers PTH/calcitriol.
I don't see that that's how it works. It suppresses PTH but not calcitriol synthesis. What happens is that the D3 and 25-OH exceedingly overwhelm the body's conversion capacities so that their concentrations (antagonists) outcompete the 1,25-OH (agonist) in VDR (but not thyroid etc. receptors) binding. Ray was hesitant in his late years to adapt a more particularized view on the matter. Marshall and associated researchers likely held back (were made to restrain?) further thoughts and implications beyond an VDR agonist mechanism and beside that the medical assocations regained a firm grip on the latter's temporary word of mouth and prescribing. As an adequate subsitute for light, sunlight, UV- and IR-spectra exposure D3 also utterly fails as the former serve far more and different physiological functions. It's another misleading narrative and false premise. Really the whole thing is kind of like a dishonest discussion on the best dosing regimen and bioavailibities of dexamethasone against one's inflammated lungs and breathing impairments without ever looking for or even caring about pulmonary TB or an asbestos environment. Or discussing the ideal continuous application forms of ibuprofen or diclofenac against somebody's pelvic pains while neglecting any UTI background. It's from the tricksters' playbook.
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@CrumblingCookie Hm interesting... thanks for the reply.
I know Trevor Marshall has said in one of his lectures that there is no such thing as a vitamin D deficiency, only a calcium deficiency. Do you believe that is accurate?
After avoiding vitamin D supplementation for a couple of years (only sun exposure and going to tanning beds) my levels have been hovering around 17-18 ng/ml. Recently I started taking 5000 IUs oral vitamin D to see if it would help with my slightly translucent teeth and neck stiffness.
Not sure but I feel like my teeth are looking a little more solid, and I also feel like it has helped with energy levels. But it also makes me feel extremely lethargic and stupid, like a cortisol crushing feeling, so I've stopped taking it for now.
The hype around vitamin D3 supplements feels like a psy-op, but who knows...
I think I will just have to move to Spain or something
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@LucH Much appreciated!
I've been away for several days and need to read through all of your provided notes.
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@CrumblingCookie
I appreciate the alternative view. I'll consider what you say and weigh it against against the various perspectives. Thank you. -
@Korven said in Chris Masterjohn: Salicylates are Toxic:
I know Trevor Marshall has said in one of his lectures that there is no such thing as a vitamin D deficiency, only a calcium deficiency.
And yet another perspective, from the RPF, some years back where I was corresponding with someone who felt:
"Basically, I think a vitamin D deficiency is indicative that you a) may have excess calcium and your body is trying desperately to avoid absorbing more..."
Interesting and challenging to have all these perspectives.
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@Mossy said in Chris Masterjohn: Salicylates are Toxic:
I appreciate the alternative view.
I'm trying to connect the dots between active vit D3, what could be seen as an excessive take, VDR enzyme blocked and defensive mechanism and poor liver metabolism...
Vitamin D, Calcium and mineral metabolism with Dr. Ray Peat and Kate Deering. Jun 23, 2021
From Winatlife Podcast transcript
Dr. Peat uses the references of 25OHD /hydroxycholecalciferol (stored) and 1,25D (active).
https://www.youtube.com/watch?v=ur9F7THGBLg (Possibilité d’afficher la transcription pdt l’interview). 1.46’As a reminder Vitamin D has many names
The three most mentioned in this podcast are
Cholecalciferol [or calciferol] also known as D3 (what is in food, fish oil, or supplements).
"Stored D" also known as calcidiol / 25OHD /hydroxycholecalciferol
"Active D" also known as calcitriol / 1,25DIn this episode we talk about…
The purpose of Vitamin D.
How is vitamin D metabolized and stored.
How much D is too much?
The difference between Active and Stored Vitamin D.
Can "stored D" have active properties?
Is elevated Active D (1,25D) a good thing?
Do Vitamin D supplements suppress the immune system?
The Vitamin D "receptor" theory-is it correct?
Are blood levels of stored D (25OHD) correct?
What are optimal stored Vitamin D levels?
The relationship between D and Ca.
Understanding the importance of parathyroid hormone (PTH).
What can affect PTH besides Calcium and Vitamin D.
What causes calcified tissue.
Understanding the calcium -magnesium connection.
What ratios, if any, are optimal for minerals?
Understanding Hair Tissue Mineral Analysis? Are they accurate?NB: I've got the script version. Still Trying to connect the dots. I'll do it with RP & CM, to avoid mismatch. Personal opinion. Need time. For an advanced state comprehension.
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@Korven said:
that there is no such thing as a vitamin D deficiency, only a calcium deficiency. Do you believe that is accurate?
Yes. Regular small amounts of calcium. Boron also plays along with that through a variety of mechanisms incl. hormones, aluminum and renal mineral retention. Potassium is a big factor for the latter as well and by itself boosting magnesium sufficiency. And menatetrenon K2 mk4 is noticably powerful.
@LucH said:
pdf transcript link
Ray talked about it between minutes 35-46. By the sound of it Kitty was rather a little befuddled and disappointed wrt his replies. I certainly am. It was a half-informed and condescending rant that sticks out from this more commonly applied modesty. He was all into anti-inflammatory arguing that non-inflammated cells and tissues were strong and resilient enough to withstand irritants. There's a good core belief in it but as one follows it round the circle it's incongruent and nonsensical. His concept of immunity was that it increases inflammation and that's bad and for the old and sick (...). I fear you won't be able to connect the dots from that.
indeed.
I dare say could Travis have followed this up he would have delivered a coherently explained and backed-up piece of work. -
@CrumblingCookie said in Chris Masterjohn: Salicylates are Toxic:
I dare say could Travis have followed this up he would have delivered a coherently explained and backed-up piece of work.
Thanks for your input and the warning (inflammation). I appreciate. I'll try to find Travis post on old RP forum, though I have to proceed indirectly. I no longer go there if I can avoid it
No need t explain why, I think.
Bye. -
@LucH said in Chris Masterjohn: Salicylates are Toxic:
Still Trying to connect the dots
Indeed. That is the entire challenge — properly connecting the dots.
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@LucH Why would you rather use potassium bicarbonate?
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@literofmilkaday said in Chris Masterjohn: Salicylates are Toxic:
Why would you rather use potassium bicarbonate?
I suppose the question is: Why would you rather use potassium bicarbonate, preferable to sodium bicarbonate?
=> Sodium bicarbonate (NaHCO3) is approximately 60% bicarbonate (HCO3-) and 40% sodium (Na+) by mass.Potassium bicarbonate (KHCO3) is approximatively 60% bicarbonate (HCO3-) and 40% potassium by mass.
Why K?
Short answer:
I emphasize the balance between Na/K with Potassium.. I have to take care (cramps, under control) with Na/K and Ca Mg. K and Mg under surveillance (watch), in my case. But do not conclude without a context (time is important).Detailed explanation
When you eat one slice Gouda or ham at breakfast, you get enough salt (NaCl) (Sodium chloride)According to Cronometer
For Gouda cheese:
A single slice of Gouda (60 g) contains approximately 320 mg of sodium.
213.6 K/cal. P15 F16.5/10.6 C1.3 and 491.4 Na, 420 Ca, P 327.6, K 72.6 in mg.
A single medium-sized slice of Gouda (60 g) contains approximately 320 mg of sodium.
For ham, canned, visible fat eaten (60 g)
A medium-sized slice of ham (60 g) contains approximately 564 mg of sodium.
135 K/cal. P12.3 F9.1/3 C0.3 and 564.6 Na, 4.8 Ca, P 145.8, K 214.2 in mg.For my last breakfast:
½ tsp coconut oil
1 very small fried onion
50 g English canned bacon (not smoked, but well salted, and with nitrites!) (If I had taken one slice 0.5 cm thickness, I could have eaten pork with no salt added, and chiefly without any nitrite, used as conservative, to keep the “red color”).
2 eggs
and 2 fruits. Let’s say one medium pear, and 120 g blueberries.=> If I add some more sodium from bicarbonate, instead of potassium bicarbonate, I emphasize the unbalance between Na/K.
Of course, we have a dual side of view here:
an appropriate pH for digesting protein (bicarbonate alkalizes the bowl),
the amount of sodium (Na)
the balance Na/K
and the combo high fat + nitrite + acidity, likely to produce nitrosamines, unless you decide to, counteract the process.I can develop how it would be interesting to manage, but only if someone is interested
to avoid a wordy talk. -
4,550mg of aspirin split morning and night was the only thing that completely stopped the worst allergy season reaction I’ve had in a long time. (+ ton of vit K)
I could afford to skip all the other aids a few times: antihistamines, biotin, water, caffeine, but if I skipped aspirin it was not a good time.
FYI, all those things combined made it feel as tho I didn’t have any allergic reaction (other than the grogginess from benadryl and cypro)
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@LetTheRedeemed Out of interest, did you try vitamin E? That was immensely helpful to me this year during allergy season, and worked better than pharmaceutical antihistamines, for me personally.
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@rpc not other than that in progest-e. I’ll definitely remember that next time. Thanks!
I’ve often thought that things like regional rashes and histamine reactions are likely due to chronic nutrient deficiencies, and topical fat solubles are probably useful. As an aside, I started to get a chronic itch on my neck turn into a rash (where it’s come and gone often), and put topical vit A on it, and it went away. I bet the whole range of vitamins is best!
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Danny Roddy has some tips for safely using aspirin:
https://dannyroddy.substack.com/p/bioenergetic-basics-2-safe-and-unsafe
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@PranaDeva said in Chris Masterjohn: Salicylates are Toxic:
Danny Roddy has some tips for safely using aspirin: ---
Hi, I didn't read DR's tips. An excerpt would be appreciated
I won’t begin taking daily aspirin at the autumn. Whatever the dosage may be: 81 – 350 or higher dose (500-1000 mg). The impact on platelet aggregation is concerned. Long term use is different. The body counteracts / adapts its production.
Why?- Irreversible inhibition of platelet aggregation, typical for acetylsalicylate, has been observed. Need 7-10 days to produce new platelets if you got the right nutrients. So, need pause if you do so. 10% renewal per day.
- Prevention for SARS-cov-2.
A low amount of platelets is dangerous with Sars-Cov-2 when the immune system over-reacts.
Source: European Medicines Agency (EMA) / Herbal Monograph on Salix purpurea / other Salix spp. Cortex.Page 36–37 (Discussion) of the PDF. *
Chemically and pharmacologically, salicin (the main pro-drug in willow bark) is converted to salicylic acid and does not contain the acetyl group that allows aspirin to irreversibly acetylate COX-1 in platelets. Because of that, willow/salicin does not produce the same aspirin-like irreversible antiplatelet effect — clinical and regulatory reviews report little or no aspirin-equivalent platelet inhibition with standard willow bark extracts, and when inhibition is observed it is markedly weaker than with aspirin.- Access to the PDF EMA’s herbal medicine portal:
https://www.ema.europa.eu/en/medicines/herbal/salicis-cortex
Scroll down to “Documents” → click
“Assessment report on Salix (various species)… 31 January 2017 (PDF)”.
This is a free and public document (no login, no paywall).
That PDF (about 47 pages) is the full European regulatory review of willow bark (Salix cortex).
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@LucH I thought vitamin K fixes that. No?
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@LetTheRedeemed
Not sure. For clotting in normal circumstances, yes. Could do it.but without platelet, how ?
Have to verify..
