Fenclonine
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@jamezb46 said in Fenclonine:
Cabergoline
Risk of valvular damage
Bromocriptine
Same
Pramipexole (more extreme from my understanding)
"Newer dopaminergic drugs like pramipexole have not been studied enough, even though they seem OK for now. I agree with Peat's principle to not trust drugs that have not been in the market for at least 20 years. Clinical trials are nothing more than a sharade proving merely that a drug won't kill too many people in too short of a time." - Haidut
Selegiline (probably the best option)
This one could work, but where perhaps can I procure such a substance?
I already have lisuride but it's pretty expensive and only a partial serotonin antagonist. The main reason I wanted to smash serotonin was this:
pCPA was used extensively in the 60s and 70s especially by US military scientist for some unique and I'd say bizarre experiments. It was used as a drug to induce "gay" behavior in humans, but they found out that it simply increased libido dramatically, where in the rats it made them lose preference for sexual partners and made them mount even...cats! So, it's not like the rats became gay, they just lost all fear and dedicated themselves to sexual "exploration" (even with cats), which, as you know from reading Peat, is a hallmark of health.
With such ridonkulicious results, I just have to try a replication study.
Update: Upon doing a little more research, it appears as though fenclonine doesn't work very well in humans, but there isn't much data available.
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https://mexipharm.net/categories/Depression/Emsam
I think phenylpiracetam could also be useful, but if you use it you probably need to look into sleep optimization because some people claim that it induces insomnia.
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@jamezb46 I just ordered some pramipexole because it appears as though it is in fact Peaty (it's been 29 years and there are no signs of effects other than those from dopamine agonism).
Let's see what happens!
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Wow! These articles are walking advertisements for the efficacy of pramipexole:
https://www.bbc.com/news/articles/cpqnpryxvrro
James's case is one of 50 the BBC has now been contacted about, the majority concerning men being treated for movement disorders whose behaviour changed dramatically after being prescribed medication from a specific family of drugs.
Often, behaviour changed after many years of taking the medicines at increasing doses, the men told us.
In March, we revealed how women had not been warned by doctors that taking the same type of medication for restless leg syndrome (RLS) could cause them to cruise for sex and gamble compulsively - placing them at personal risk and ruining their finances, careers and relationships.
https://theamericanscholar.org/the-degradation-drug/
It started with selfies. Hannah had never taken a selfie before, or even given the idea much thought. She was a tenured 39-year-old psychology professor at a New England college. But eight days after she started on pramipexole, a drug prescribed off-label by her psychiatrist for depression and anxiety, Hannah began taking photos of herself obsessively. She couldn’t explain the desire. At the time, it didn’t even seem especially strange.
Neither did the hats. She just felt like wearing them—or, really, any item that would cover her head. A gray wig. A red fedora. A spider-webbed fascinator. A vintage, canary-yellow beehive cap. Ordinarily Hannah was a modest dresser. But within weeks, she began ordering exotic clothing online, including flamboyant suits made for adolescent boys. “I had green velvet, red velvet, black velvet,” Hannah told me when we discussed her case. “I had my tuxedo. I had my plaids.” (To protect Hannah’s privacy, I have changed her name and some of the identifying details of her story.) Many of these outfits were impulse purchases. “Sometimes I could drop a grand in less than 30 minutes, waking up in the middle of the night to shop,” she said. One selfie from this period shows her wearing headphones, a short strapless dress, and a Batman mask. Men began to pay her a lot of attention. “I didn’t think to stop and analyze too much what was happening,” she said. “It was a constant rock ’n’ roll party in my head, and I was the star.”
Us Peaters will almost certainly be in better shape.
Edit: Another one!
https://www.bbc.com/news/articles/clym0g4rlr2o
Edit 2: it just doesn't stop coming in
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@engineer safegenericpharmacy in india sells it
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@sunsunsun I got it from BlueSky
Another FUD article for you
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Watch engineer smash all the tortas in Miami now
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Estradiol valerate, pramixepole, modafinil and trenbolone acetate to reduce le stress hormones
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@engineer since you are their number one customer please kindly ask PPL to send me a bottle. Threaten them with purchasing T Iso elsewhere if need to.
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@alfredoolivas ok, but what are you going to use the estradiol valerate for? that has to be the most unpeaty thing I know of unless you crashed your e2 with too much exemestane.
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@engineer Intuition.
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@engineer fentclonine is a scam, overhyped drug spread by that famous twitter post because of the chicks participating that tried to rape the scientists
fenclonine's real name is para chloro phenylalanine, its a chlorinated version of the amino acid phenylalanine where it has one singular chlorine atom at the para position of the phenyl ring, basically a chlorinated version of the amino acid
if you know what phenylalanine is, you would see that on top of it beeing a substrate for tryptophan hydroxylase, its also a substrate for tyrosine hydroxylase, the rate limiting enzyme for dopamine production, hence why this same study showed that fenclonine negated the effects of the anti depressants they were taking (that worked dopaminergically
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@engineer said in Fenclonine:
Neither did the hats. She just felt like wearing them—or, really, any item that would cover her head. A gray wig. A red fedora.
nigga destroyed her crown chakra
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@engineer said in Fenclonine:
This one could work, but where perhaps can I procure such a substance?
ngl just look up "buy selegiline perscription free [your country]"
I ended up buying it from bgpharmaceuticals.to
they need you to buy stuff for at least 90 ish dollars, I ended up buying 3 packets of turkish thyroid (100x 50mcg t4 12.5mcg t3) and 1 packet of t3 (100x 25mcg t3) , doxycycline and selegiline, quite cheap if u woulda asked meedit: forgot to say, but this nigga takes like 4 weeks to ship your shit, and doesnt respond to emails
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@alfredoolivas whats w modafinil beeing good for u, its mechanism is it beeing pro histamine
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@hwisdom If i was doing stuff that was good for me, i wouldnt have an account.
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@alfredoolivas hahahahahahaha oh wow
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Last one
https://kevinmd.com/2025/11/a-cautionary-tale-about-pramipexole.html
I never thought I’d be the cautionary tale.
For decades, I worked at a financial company. I’m a youth sports coach, a husband, and a father of two. I’ve spent decades coaching, mentoring players, and proudly producing high school sports telecasts. I built a life around leadership, precision, and community.
But none of that prepared me for what happened when I was prescribed pramipexole (Mirapex) to treat Parkinson’s.
The warnings were there: compulsive behaviors, gambling, and hypersexuality. I read them. I nodded. I thought, That won’t be me.
But pramipexole doesn’t come for you like a thunderstorm. It rewires you slowly. Quietly. It doesn’t feel like addiction. It feels like urgency. Like logic. Like a voice that sounds like your own, telling you this next step makes sense. Until it doesn’t.
I lost control. I made choices that devastated my family. Financial ruin. Emotional collapse. The kind of betrayal that no apology can fix. And when I finally came out of the fog (when I tapered off the drug and the compulsive pull vanished), I was left with the wreckage. The clarity came too late.
Since tapering off pramipexole, the compulsive urge is gone. It’s not dulled. It’s not managed. It’s gone. I don’t feel the same pull, the same irrational need, the same hijacking of my thoughts. That switch, the one that used to flip without warning, is silent now.
But that doesn’t undo what happened.
I sit here now knowing that I have ruined the life of my family. I realize there is nothing I can do to change what my brain did under the influence of that drug. I gambled away everything that would have made a life for my children and my wife. What I’ve done is costing me more than I ever imagined: not just the money I lost, but the tax consequences that may prevent my children from finishing college, and burden my wife for the rest of her life.
And I still have Parkinson’s. That won’t get better. I will need help, help I won’t be able to give myself. And my wife won’t be able to be everything for me or for herself. I fear what that means for her. For us.
I feel useless. Guilty. Ashamed. Like I’ve taken a step backward. But I also know this: I’m not hiding anymore. I’m telling the truth. I’m seeking help. I’m writing every day. And even if I can’t fix what’s broken, I can make sure no one else walks into this blind.
Here’s what I need you to understand: The risks and warnings won’t protect you.
You can read them. You can believe you’re immune. But pramipexole doesn’t ask for permission. It changes how your brain processes risk, reward, and impulse. And by the time you realize something’s wrong, you may already be deep in it.
This isn’t just a medical side effect. It’s a neurological hijacking. And it nearly cost me everything.
If you or someone you love is taking pramipexole (or any dopamine agonist), please don’t dismiss the risks. Monitor behavior. Ask hard questions. Don’t wait for the damage to show up before you act.
I’m not asking for forgiveness. I’m asking for awareness, for accountability, and for a system that doesn’t bury these risks in fine print. And for families to know that if something feels off, it might be more than just stress. It might be the drug.
This is my story. And I’m still living it.
RAY. PEAT. Wonder if he was laden with estrogen and PUFAs!
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The connection between dopamine and serotonin
It just so happens that dopamine and serotonin have an inverse relationship. Each one suppressed the levels of the other. Thus, when serotonin is high dopamine is low and vice versa. That relationship extends to synthetic molecules that mimic the effects of serotonin or dopamine at the receptor level. For example serotonin agonists suppress dopamine synthesis and vice versa.
Serotonin (5-HT) promotes blood vessel thickening, may cause cardiovascular disease (CVD)
Serotonin (5-HT) may drive brain/liver/pancreatic and many other cancers, at the genomic level
Serotonin (5-HT) increases inflammatory mediators (IL-6, NF-kB), may cause atherosclerosis
SSRI drugs, serotonin (5-HT) can cause chronic fatigue syndrome (CFS)
Blocking serotonin may treat obsessive-compulsive disorder (OCD)
Drop in dopamine behind giving up
And it goes on and on and on!
https://haidut.me/?s=serotonin
Looks like maybe microdosing a DA could be the way to go?
Edit: Looks like the weird side effects from DAs are truly just a stress response?
https://lowtoxinforum.com/threads/dopaminergic-drugs-like-bromocriptine-may-treat-alcoholilsm.11828/
