Creatine and Ray Peat

Santosh

@Buckian said in Creatine and Ray Peat:

@Santosh this is an option. However, if the concern is overdosing further research and prudence may help.

Overdosing creatine ?

Just take 5g and go on about your day, I swear you guys are creating problems that don't even exist in the first place.

risingfire

@Santosh lol

Buckian

@Santosh lol. Touché.

Santosh

@Buckian said in Creatine and Ray Peat:

@Santosh lol. Touché.

Stop loling unless you also use pronouns to define yourself.
Keep a serious tone, work hard, have values, stop taking everything lightly, be rigorous.

yerrag

@Santosh

I'm with you.

Peat has made references to A Greek doctor and his clinical experiences on treating patients with urea and with creatine.

Urea used on wounds has antibacterial effects in that it cleans up decaying flesh in the wounds, thus depriving bacteria of food and in this way stops infections dead on its tracks. I use urea on my wounds and on my pet cats' wounds. Very very effective.

It has a similar kind of effect when ingested, as it goes to the liver and heals the liver. I've taken 30g/day for two weeks each time, and have seen my ALT and AST enzymes go down.

However, urea is deactivated past he liver and does little internally. And this is where creatine is used.

I would put 30g urea and 14g creatine in a liter of water and drink it throughout the day. At worst, the creatine would do nothing. As that has been my experience once.

But I plan on taking this shortly for two weeks, as I want to see the effect on my ataxia (or Parkinson's). My theory is that creatine would work like urea on the protein sediments or sludge on the blood vessels and clear them up. I can see this in the ESR going down if it works as I think it should.

With ESR going down, blood flow would also improve and the delivery of nutrients and oxygen to the brain would improve, and as a result my symptoms of ataxia would go away.

Santosh

@yerrag said in Creatine and Ray Peat:

@Santosh

I'm with you.

Peat has made references to A Greek doctor and his clinical experiences on treating patients with urea and with creatine.

Urea used on wounds has antibacterial effects in that it cleans up decaying flesh in the wounds, thus depriving bacteria of food and in this way stops infections dead on its tracks. I use urea on my wounds and on my pet cats' wounds. Very very effective.

It has a similar kind of effect when ingested, as it goes to the liver and heals the liver. I've taken 30g/day for two weeks each time, and have seen my ALT and AST enzymes go down.

However, urea is deactivated past he liver and does little internally. And this is where creatine is used.

I would put 30g urea and 14g creatine in a liter of water and drink it throughout the day. At worst, the creatine would do nothing. As that has been my experience once.

But I plan on taking this shortly for two weeks, as I want to see the effect on my ataxia (or Parkinson's). My theory is that creatine would work like urea on the protein sediments or sludge on the blood vessels and clear them up. I can see this in the ESR going down if it works as I think it should.

With ESR going down, blood flow would also improve and the delivery of nutrients and oxygen to the brain would improve, and as a result my symptoms of ataxia would go away.

Don't use creatine if you are still drinking coffee, it will make you pee like a horse and wake you up multiple times at night.

Buckian

@Santosh easy there brother - you’re ganna hurt yourself.

You may notice that the original question in the post was about Dr Peat’s thoughts on creatine (not what current studies/conventional wisdom are for dosing creatine). My response was saying that I recall Dr Peat saying that a dose of 5g per day is too high but cannot recall the exact reasoning. Now the concern of ‘overdosing’ would be in light of this paraphrased Dr Peat statement - not because I think it’s a concern.

So if anything - I would say that I’ve taken this thread more seriously than you by actually answering the question at hand and not making assumptions about the users and their comments.

So as you say be rigorous.

Santosh

@Buckian said in Creatine and Ray Peat:

@Santosh easy there brother - you’re ganna hurt yourself.

You may notice that the original question in the post was about Dr Peat’s thoughts on creatine (not what current studies/conventional wisdom are for dosing creatine). My response was saying that I recall Dr Peat saying that a dose of 5g per day is too high but cannot recall the exact reasoning. Now the concern of ‘overdosing’ would be in light of this paraphrased Dr Peat statement - not because I think it’s a concern.

So if anything - I would say that I’ve taken this thread more seriously than you by actually answering the question at hand and not making assumptions about the users and their comments.

So as you say be rigorous.

I was refering to your "lol" which was useless.
Don't do useless things, it's annoying.

And stop writing lengthy paragraphs, it's highly feminine. I can almost picture you beginning every sentence by "excuse me but" when talking in real life.

yerrag

@Santosh Thanks. I already pee a lot at night, and I wake up a lot because of it. So, I may cut back on the coffee once I get started on my urea/creatine intake.

My ESR got very high when I was having bronchitis. My red blood cells and hemoglobin went down as well. I suspect many red blood cells died as a result (hemolysis). After my bronchitis was fixed and my lungs restored to full breathing, the red blood cells that died are slowly being cleared by the system in the backed up lymph nodes (as evident in a swollen elbow lymph node) as well as my ESR being high (from 54 to 31 e 3 months ago to the current 14).

I suspect in order to clear the RBCs , a lot of waste has to be excreted and a lot of this waste is being phagocytized and being released as feces, urine, and even phlegm.

Which is why the current high urination rate and volume is occurring with a lot of foaming, and why when I am lying down, a lot of white or clear foamy phlegm is coming out. Normally, this isn't so evident but the amount of waste being cleared can't be handles by the liver and gallbladder alone, which excretes via the fecal route. Even then, my stools has been unusually loose and this strengthens my theory.

I am monitoring my ESR to see if I can go back to my normal state 5 years ago, where my ESR was a perfect zero.

I hope taking creatine would speed up the clearing of sludge in my vessels.

Tying loose ends and connecting the dots, and based on my own experience (what can I say- it can be faulted for just being my n=1), I'm learning a lot about what causes my bp to be high and how I can naturally lower it (a work in progress but seeing the light at the end of the tunnel).

Also, getting similarly developed first person-based experiential insights into why I developed Parkinson's and how I can make it go away. I think taking thiamine helps, but I think that a lot more has to do with the inability to deliver enough nutrients and oxygen into my brain- the nerve center- because the microcirculation (capillaries) are obstructed by sludge. Metabolism in the brain down regulated to anaerobic glycolysis from efficient mitochondrial respiration due to lack of enough oxygen being supplied.

Clearing the sludge to get the oxygen supply back is important, and I hope creatine can help with that.

@mostlylurking I think (I have not been reading a lot lately so I could be wrong) that anaerobic glycolysis is wasteful of thiamine, and that thiamine mega dosing helps, but clearing the capillaries of obstruction to make oxygen available to the brain fully is the way to fixing Parkinson's. Thiamine megadosing helps by compensating for the inefficiency and wastefulness of anaerobic glycolysis.

@yerrag said in Creatine and Ray Peat:

@mostlylurking I think (I have not been reading a lot lately so I could be wrong) that anaerobic glycolysis is wasteful of thiamine, and that thiamine mega dosing helps, but clearing the capillaries of obstruction to make oxygen available to the brain fully is the way to fixing Parkinson's. Thiamine megadosing helps by compensating for the inefficiency and wastefulness of anaerobic glycolysis.

Hi yerrag, thanks for the link; I always value your insight. I read through your post and immediately thought of a Ray Peat audio when he discusses vitamin K2 for removing calcium in the circulatory system.

I believe my own thiamine deficiency/functional blockage fall of 2020 derailed my calcium storage which usually means the calcium that is supposed to get stored in the bones gets stored in the soft tissue (including the blood vessels) instead. Peat related a story about a doctor he knew that used high dose K2 (40-50mgs?) to resolve his hypertension.

Thiamine is needed for good oxidative metabolism. When it is deficient, the end product of the process is lactic acid instead of carbon dioxide. If things are working right, the carbon dioxide drags the calcium inside the cell out when the carbon dioxide exits the cell (from memory - A Peat explanation from somewhere). So it makes sense that calcium storage would get derailed in a thiamine deficiency.

Here's a link or two:
https://bioenergetic.life/?q=k2
The one with the story about the doctor high dosing the K is in there somewhere....
also this:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7926526/

Please note that vitamin D, needed for the immune system to work, also is responsible for making calcium get stored in the bones; in order to do this, there needs to be vitamin K available. So I think both D and K would be helpful.