Genetically Vit A Deficient.
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I have a genetic mutation that means I'm chronically low in vitamin A.
I actually discovered this about a week before the RPF went into the deep end of vit A toxicity and to be honest it left me feeling adrift.
Anyhow, this is what I'm dealing with:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9096837/
"Casey reported that the G304K mutant STRA6 protein is mislocalized and has severely reduced vitamin A uptake activity (75). Besides rs151341424, four common missense variants, rs736118, rs351236, rs971756, and rs76336272, have been identified. Of those, rs971756 and rs736118 are reported to be linked to human diseases (77-84)"
I have all of the SNPs discussed from the information above (traveller DNA).
Anyhow, my vitamin A is low and I don't feel like a radiant healthy being.
I think it's potentially linked to my chronically low K1/K2 levels no matter how many well cooked greens.
I raise my own 100% grass fed beef, pork, eat organs, eggs, milk, butter, tallow, lard, grow my own garden, eat all the well cooked veggies, fruits etc.
You get the picture.
It just doesn't matter.
Here's the odd thing:
I'm also somehow deficient in Vitamin C, L-Valine, & L-Isoleucine which with the vitamin C being involved in protein metabolism I'm wondering if this is how I'm someone low in these AAs even though I eat ample varied proteins.
I've also read that vitamin c is needed for converting beta carotene into retinol so this feels like a double whammy with a genetic mutation that prevents it and a deficiency that increases it.
(I eat a lot of vit c rich foods by the way.)
Then, I got my liver testing back. I have elevated oxidative stress (not surprising) but somehow really low inflammation?
I guess I don't have a specific question or anything but welcome ideas, it's all just weird and I thought I'd let people know about the possibility of being genetically deficient in Vitamin A.
I've attached my labs.
Oddly enough Thyroid is fine, temps are always between 98.8 & 99.3
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@MostlyCurious I'm no expert on this, so it might be beneficial someone else could confirm/deny this. But may a higher copper intake reduce oxidative stress? I know mineral balance is essential and copper is known to fight oxidation.
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@Ruben I actually do eat a fair amount of copper rich foods and on my labs I'm in the upper range of normal.
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Just to add to this thread:
I've been taking 25,000iu vitamin A (retinol) in the evening alongside 5000iu vitamin d for about four days now and I am already noticing a difference in how I'm feeling. (Less avoidance behaviors/more calm energy/body temps are stable at 98.8 vs spiking up to 99.4+ mid day)
I'm not low in vitamin D so I suspect it's the vitamin A although because I'm genetically weird I'm not sure if the improvements would last if I for example only supplement the retinol for say a month.
But also... maybe the increase in vitamin K is finally taking hold now that there's vitamin A?
At this point the best I can do is pay attention to how my body feels and try my best to wean eventually from the supplements onto a high vitamin A(retinol) vitamin K diet.
Just thinking out loud.
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@MostlyCurious Geneti-what now??
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@CO3 Genetically, I have genetic defects that prevent me from converting beta carotene into retinol. It's also hard for my body to utilize retinol.
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@MostlyCuriou is that some kind of insect?
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@CO3 Can't tell if you're trolling me or not but here's a dictionary definition for you:
genetically
adverb
US /dʒəˈnet̬.ɪ.kəl.i/ UK /dʒəˈnet.ɪ.kəl.i/In a way that relates to genes (= units of DNA received by an animal or plant from its parents) :
The brain's response to pain is, at least in part, genetically determined.
Children born from embryo donation are not genetically related to either their mother or father.
In other words I have genetic differences that I inherited from my father that prevent my body/liver from working with vitamin A / beta carotene the same way other people's do.
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@MostlyCurious who gave you this idea
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@CO3 It's not an "idea" it's something that I am living with and have confirmed through genetic testing. It's also something that's common in my culture, so much so we're discussed in the study I linked above.
We even have to be really careful during pregnancy as the low vitamin A levels often lead to Mathew Woods syndrome.
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Is this similar to the genetic inability of caucasians to convert beta carotene to vit A?
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@AltarandThrone I'd have to see what SNPs are related to see if it's the same but seems to be the same end results regardless of SNPs.
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@MostlyCurious ok. I know nothing about genetics heh
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@AltarandThrone Learning about and digging into my own genetics has had a huge impact on my ability to pinpoint health issues.
I started with simply uploading an ancestry DNA file to self decode.
That service is great for beginners (I feel anyhow) because it automatically shows you a good amount of issues you may have like MTHFR or histamine issues etc.
From there I began looking into my specific culture(s) documented issues and was able to search for specific genes/SNPs to see if I carried them.
Sure enough there they were and directly related to issues I am facing.
Then I uploaded my data to StrateGene and that was an absolutely amazing report and gave me a huge amount of insight to my health.
For the first time in two years I finally feel like I'm making headway in with my health and understanding why my body is/is not responding in certain ways others do to various Peat concepts.
Anyhow, I think in general it allows us to make health decisions in a deeper more meaningful way.
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@MostlyCurious interesting. thanks for sharing. I may go down that rabbit trail
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@MostlyCurious The firm is owned by blackstone and their medical stuff is quackery at best. Completely unscientific.
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@CO3 You think genetics are fake and genetically might be a type of insect so we'll probably just have to agree to disagree here. Take care.
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That's awesome you're feeling better now. I'm glad you didn't get sucked into the toxin A cult. I don't know anything about your particular genetic condition, but having a predisposition to a vitamin A deficiency would make something like a retinal detox all the more dangerous.
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@Ruben Maybe if you have a deficiency. Copper is very important for normal metabolic function. It's needed for thyroid hormones and the electron transport chain. Copper can also keep histamine from getting too high. There is however some things that aren't so good about it. It synergizes with estrogen, and is estrogenic itself. It's also an adrenaline agonist. Probably not something you'd want to supplement with unless you can confirm a deficiency with blood work. Otherwise just get it through good diet.
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@MostlyCurious You can block users for sanity purposes
