DEPRESSION
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@basebolt 2,000mcg is an extreme dose. Thyroid is cardio protective in most cases (look into Broda Barnes's work). People with heart complications are recommended to start out at lower dosages and gradually buildup. But using it like a stimulant how bodybuilders do isn't that healthy. I take 3 drops of TyroMix 3x daily. So that's a total of 54mcgs of T4 and 27mcgs of T3.
Broda Barnes suggests it's rare, but some people may need up to 4 grains of thyroid daily. 4 grains (Which is a lot according to the leading MD in this field) is 152mcgs of T4 and 36mcgs of T3. So, to reiterate, 2,000mcg is EXTREME.
I would guess those people survived because they were administered an anti-thyroid medication, possibly intravenously. Which is a lot more certain than drinking raw cabbage juice, which may or may not work for massive overdoses. Don't do something stupid. Just try thyroid at a normal dose and gradually buildup until symptoms subside.
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Eat high carb + very low fat bro ( carbs 400 gram + , total fat below 10 gram , PUFA below 1,5 gram)
Supplement thiamine HCL at 300 - 500 mg daily to turn the carbs into CO2.
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I know people don't want to hear that on Peat-related forums, but have you considered that your symptoms might have psychological causes?
If you're aligning the basics of your diet with Peat's insights, you're already doing better than 99% of the population on that front. So perhaps the solution isn't the final weird supplement cocktail, diet mineral ratio or detox procedure? I am talking from personal experience. Thought and metabolism are strongly interrelated. Ironically, Ray has done a lot of work related to that, but people usually focus only on his work related to nutrition and hormone physiology, because it's more easily accessible and closer to the Zeitgeist.What does your living situation look like? Do you have family / people around you, who care about you? How many hours a day do you spend consuming media? How many hours a day do you spend doing something creative / productive? ...
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I'm facing this consideration too currently dude... Very interested to hear what is said on this thread the next few days
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Feeling consistently much better. Still have chronic depression, however there is a sense of peace and calm now. It is more bearable.
The basic Peat advice is good and there are some specific things too that are potentially helping.
Methylene Blue
From a high quality source. Haidut mentioned 10 mg / day being useful for depression and that is what I use.Cyproheptadine
Low dosage, and thrice per day because that makes it more effective. Sometimes my first dose will be metergoline instead.Folinic acid
The other B9 forms, folic and methylfolate, are toxic at high doses. This isn't necessarily Peaty and could have negative effects. It apparently may have Peaty epigenetic effects. 20 mg / day from a dropper bottle.Salt supplementing
AlloP from idealabs
High doses and low doses. Sometimes intranasally and in the eyes.Many of these I cycle off of for a little bit. Will be trying Peaty euphoriants/antidepressants like LDN and selegiline (cautiously) soon. Also I see a psychologist infrequently.
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After eliminating gluten from my diet my 50 years of chronic depression completely went away. I would definitely try 4 weeks gluten free to test.
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Zinc (moderately high dose, around 60mg)
Methylene blue, 2mg
Aspirin
Thyroid
Cyproheptadine, 3mg (in the evening before bed)These are the most helpful supplement interventions I've found for mood issues and depression. Also make sure you're eating enough protein (I would aim for 1.2g/kg bodyweight minimum)
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Thanks guys
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How was your bromantane experience? Have you tried kratom? Its not meant for long term use but its an antagonist at 5 ht2a and 2c iirc and agonises presynaptic 5 ht1a , also has some action at MOR (which we dont want but can be helpful short term esp. if pain issues) and at NMDA (antagonist). Its also an instant fix for anhedonia.