L. Reuteri
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This is the infamous study showing high testosterone big-balled mice:
The effect on testosterone was wild, showing a 5-10 x increase, with the increase being higher on a high fat diet.
It seems that those benefits are downstream from lowering IL-17:
"We found that blocking pro-inflammatory Il-17 signaling entirely recapitulates the beneficial effects of probiotics (Fig. 6). "
There was recent human study showing no effect on testosterone, which is quite surprising, so it isnt certain that these effects translate to humans.
But I don't know if the dosage was high enough in the human study and I've read numerous anecdotes of people that repeated the effects from the animals studies.
Like one gentlemen said je regrew his hair and had symptoms of high testosterone, and he had been taking it for years already. IIRC it was a different strain than 6475 and he took a high dose. I'll see if I can find this. -
This is the gentlemen I was talking about above :
"I’ve been taking it for years. My sex drive is back! My testicles are bigger. My low T is gone. And my hair is growing back on top of my head. Slowly but it’s getting there. L. rhamnosus is also a good probiotic to take. It helps with circulation which helps with hair growth.I use custom probiotics dot com. They seem expensive but 50 grams would last near 2 months if you take the big scoop. It’s powder. My concern was that our stomach acid would destroy it. The guy who owns the company is a microbiologist and he assured me that it doesn’t. The proof is in the pudding. Been using it for over 2 years and I’ve seen the difference. In my lab values as well as the way I feel and look. I also take cold showers everyday and cold plunges whenever I can. My T level was below 250 which is very low for a male. It’s well above that now. I haven’t checked it in years. I see no reason to. Because I feel way better."
I checked the website he mentioned he takes 40 billion of a strain called UALre-16. So there is another strain that seems to work for testosterone enhancement.
This is a big dose compared to the 100 million that are in bio gaias gastrus . I think os Fortis contains 5 or 10 billion per tablet , so still a lot less.Here is one person reporting good results from low doses :
"It's fantastic if I get the dosage right. Definite oxytocin (it's easier for me to be social, relating to people, finding the right words) and testosterone boost (libido is definitely higher, and the testicle size increase thing might be true). It also seems like an extremely potent appetite reducer as my body weight has never been this low, though I've always had low body fat so I'm not sure that's a good thing for me long term. Skin is a lot clearer and smoother.
As someone with Aspergers/Schizoid (?) personality it's one of the most effective supplements I've taken regarding sociability, and I've tried a lot over the years. A bit similar to Phenibut during the honey moon phase before the tolerance and withdrawal kicked in.
I don't bother with making yoghurts as I get such significant effects just nibbling a bit of the 6475+17938 pill once in a while. The side effects are awful if I take too much too often however: itchy skin, horrible gas, stomach pains, constipation & insomnia lasting for at least a week. So I would tread carefully, and start slow, just in case.
I have 6475 as a stand-alone pill as well but it's way too strong for me and harder to dose. My theory is that you can get benefits off small doses of it after a "loading" phase, but your mileage may vary."
Here's a high dosage proponent :
"Yes, it is one of the most important probiotics you can take for gut inflammation and health. It has had profound effects for my wife and her hormone levels and I take it for skin and hair. I've been taking it for years and it took about 6 weeks to notice effects, but when they do take effect it is very noticeable. Shiny hair, clear glowing skin, head hair growth, strong nails are all physical aspects. But it also helps with lipid levels and as mentioned, hormone balance.
But, you need to take way more than 100mil. I take 100 billion in a complex daily."
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The strain called ID-D01 lowered lactate and ammonia after exercise and increased glycogen storage.
It also increased Akkermansia and SCFAs like butyrate in the gut."Results indicated that ID-D01 supplementation significantly improved endurance performance. Rats in the probiotic group demonstrated a significant increase in maximal running distance compared with that in the control group (p < 0.05). Additionally, levels of fatigue markers, such as lactate and creatine phosphokinase, were significantly reduced in the ID-D01-administered groups, suggesting its potential to alleviate exercise-induced fatigue. Microbiome analysis revealed a distinct shift in gut microbiota composition in response to ID-D01 administration. The group that received ID-D01 probiotics exhibited a significant increase in the abundance of SCFA-producing bacteria, particularly Akkermansia spp., compared with that in the control groups. Furthermore, they showed elevated production of SCFAs, such as acetate and butyrate."
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L. Reuteri normalizes altered fear memory and increases GABAergic transmission in an autism mouse model.
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It increases ergothioneine, which is has numerous health benefits, amongst them life extension.
https://www.nature.com/articles/s41398-020-0855-1A thread on ergothioneine:
https://bioenergetic.forum/topic/1799/ergothioneine-amino-acid-for-life-extension?_=1717938591661 -
@Mauritio very interesting stuff Mauritio, thanks! I'm definitely going to check this out.
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@Mauritio I took this a few years ago after seeing the study, every time I took it, I felt a little stressed and quite aggressive.
Got 10 boxes sitting in the fridge that have now expired - not sure if they’re even okay to take now or as “active”. -
L. Reuteri is an interesting bacteria. I have been making yogurt with the patented L. reuteri 6475 strain since November 2023. There are two important diffeneces between fermenting milk with L. reuteri verses normal yogurt cultures. It boils down to time and temperature.
Commerical yogurts are mass produced as quickly as possible. Afterall, time is $. I ferment my reuteri for 36 hours to increase its concentration.
With regard to temperature, reuteri is killed at the temperatures commonly used for commerical yogurts. (115 F). I ferment the yogurt at approximately body temperature.
Makiing reuteri yogurt is the most cost effective way to to take high doses. I use some of the yogurt that I made as feedstock for my next batch.
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If anyone here wants steps on how to make their Reuteri at home, in 36 hours with a Luvele yogurt maker (incredibly easy), let me know.
This makes yogurt that has many, many more good bacteria per ounce than the Gaia tablets, although you start with the tablets. -
I am highly interested in hearing about how you do this.
I am familiar with this particular strain as I recall hearing Bronze Age Pervert speak about the Gastrus product as far back as 2022 or earlier, and he reports similar virilizing effects. Thank you for posting these studies, I had never seen anything on it quantified like this.
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@Mauritio can you recommend a product?
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@AinmBeo said in L. Reuteri:
If anyone here wants steps on how to make their Reuteri at home, in 36 hours with a Luvele yogurt maker (incredibly easy), let me know.
This makes yogurt that has many, many more good bacteria per ounce than the Gaia tablets, although you start with the tablets.Please post your procedure to make the yogurt. Thank you,
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@AinmBeo I have been looking into making yogurt with L. Reuteri. Have you used these starter cultures https://www.luvele.com/products/l-reuteri-starter-culture-lr-superfood ? Looks better than buying the tablets. Also wondering if you find the Luvele worth the price? I usually just use a cooler with hot water to incubate yogurt for 24 hours or more.
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@Sippy
I had no luck with those.
Also, the Gaia Reuteri is the best strain out there.
Also, using the luvele to make the Gaia Reuteri is a time-tested method.
One strain, so no worries about not having the right temp. -
@Sippy
The Luvele is defintely worth the price.
It takes me 5 minutes to start the yogurt.
Pour in milk.
Put in some crushed tablets (first time) or some existing reut. yogurt (all other times).
Put in some lactose powder.
Add water to the basin.
Plug in.
Set timer and temp.
Easy peasy.
36 hours later, done.
Strain for 24 hours in the fridge.
It takes time - and almost zero effort. -
@AinmBeo could I just buy some from you? lol
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@AinmBeo Thanks for your reply.
Do you think the Luvelle would fit quart mason jars?
I see that you use lactose instead of inulin. Does this work better for you? Where do you get your lactose powder? -
@Sippy said in L. Reuteri:
Do you think the Luvelle would fit quart mason jars?
IThe luvele comes with its own glass container, which holds 64 oz.
It also comes with a top, to keep the temp even.
A quart mason jar would probably not even fit.I use lactose instead of inulin because Peat spoke against inulin, as inulin is fermentable in your lower gut. Lactose works fine.
-Where do you get your lactose powder?
amazon -
@AinmBeo why do you need more lactose if the milk has lactose already? and do you only use it in the first batch or in all batches?
