DHT powder dissolve
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This is interesting, not sure if it would be a similar process to adding DHEA to Progest-E — Danny a Roddy made a video about how to do that — or if the DHT has different solubility
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@madmac this person wrote an excellent post about DHT
https://bioenergetic.forum/topic/1238/experiments-with-transdermal-hormones/99
however, is taking DHT pointless?
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Why on earth would it be pointless?
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How much DHT in how much vitamin E? According to a post on RP forum, each drop of progest-e contains 4-22 mg tocopherols. If we estimate each drop to be 1/20 mL, and we know 100mg P4 is in 1/4 tsp of progest-e, we know that 81 mg p4 is soluble in 1 mL of a solution containing 80-440 mg tocopherols.
So, to be conservative, I would think that 40 mg DHT should be soluble in 1mL of a solution containing 80-440mg tocopherols.
For reference, the vitamin E product I have has 10mg tocopherols per drop ~ 1/20 mL. So, I would expect to be able to dissolve at least 20-40 mg DHT per mL in my solution.
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The reason why we dissolve in tocopherols is because according to Ray and also current research the tocopherols allow the steroid to travel through the body on chylomicrons that are not metabolized in the first pass by the liver.
In addition to that, there is the lymphatic system effect whereby the steroid when dissolved in a fat of chain length 12 or greater is absorbed through the thoracic duct and enters the lymphatic circulation, thus bypassing the liver on the first pass.
To be completely frank, I do not know what relationship exists between these two mechanisms. I don’t know if they are two different mechanisms or if one is the effect of the other. Perhaps @Santosh or @haidut can chime in here.
It does seem that the steroid would have to be dissolved in either the tocopherols or the longer chain fat (or both) for either effect to take place, but I don’t know for sure.
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Besides my ethanol mixtures, i also tried dissolving DHT in pure tocopherol. Tried mixing 10%, which is the same % as progest-e. I heated the mixture by placing the beaker in hot water and stirring continuously for 20-30 minutes, and it did not dissolve.
I used Cliganic vitamin E which is pure tocopherols, not diluted with carrier oils. Based on the GCMS report they sent me it is 1180iu/g. I think that's pretty decent in terms of potency?
In Ray's patent, it says the progesterone concentration can be brought up to 25% which is huge. DHT is a bit less lipophilic than progesterone, having a LogP value of 3.27 compared to 3.87 of progesterone. This is probably partly due to having a hydroxyl group at position C17 which is polar, thus reducing its solubility in nonpolar solvents (like tocopherols). So theoretically, the max solubility of DHT might be around 15-17.5%, if a 0.60 reduction in LogP value corresponds to a moderate reduction in solubility (60-70% of progesterone's).
Maybe more stirring/heat is required and/or better quality vitamin e (we need to find progest-e supplier)?
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@wester130 Both unique e and health natura are less concentrated than cliganic. Lotioncrafter looks good but the shipping is more than the product itself for me since im in Europe
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@jamezb46 Hi, sorry for late response, manage to dissolve in beaker in hot water, got it around 1mg DHT per drop. Thank you
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Ok. I plan on dissolving T in vitamin E; your claim of being able to dissolve 20 mg DHT/mL is encouraging.
Please let me know what effects you have noticed from taking it, and please include dose and route of administration.
Also, if possible I would like to know what the concentration of tocopherols is in your solution in mg/mL.
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@jamezb46 Hi, I bought bottle of Vit E and they claim it’s has 395 drops of a bottle. Added around 320mg of DHT then dissolved with hot water on beaker so aiming around 1mg of DHT per drop.
First time taking I felt a little drowsy, libido increases slightly then lowers down again next day.
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@madmac where or how did you get dht powder? im trying to find a source but i cant please help me
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@dhtpowder user pannacottas has a source
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@dhtpowder purple panda
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@wester130 do you mind posting a link for that?
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Check Qingdao sigma chemicals on thinksteroids guys.
Also im not one to gatekeep sources and stuff but you need to search more, dont expect to be spoon fed about stuff like that. On thinksteroids if you ask for source at best they'll tell you to use the search function, at worst to fuck off for creating an unnecessary thread lol. -
@pannacottas I will give a try lol
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@pannacottas sorry for outing you
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@wester130 No worries, like i said i dont like gatekeeping anyways. The more people try dht the better imo
