PUFA & weight loss

Uroš

So I was recently thinking (again) about PUFAs. And one important question that always occurs is - how does the body remove them with minimal collateral damage?

Since anytime you lose weight, they get released into the bloodstream and slow down the metabolic rate. Any good literature from Haidut, Ray Peat or someone who has the required knowledge?

Kind regards

herayclitus

The standard answer people give is that the liver can detox them through glucuronidation, if you consume enough gelatin, protein, and carbohydrate

But Peat also mentioned just having a high metabolic rate so they clear from your system quickly mitigates the damage. Vitamin E, aspirin, and of course thyroid might help too, I'd imagine. With these precautions I wouldn't worry too much about the negative effects of fat loss unless it actually makes you feel bad

LucH

@Uroš said in PUFA & weight loss:

how does the body remove them with minimal collateral damage?

The liver is going to help if ...

How toxic are PUFA’s?
*) From Ray PEAT
It isn't the quantity of these polyunsaturated oils which governs the harm they do, but the relationship between them and the saturated fats. Obesity, free radical production, the formation of age pigment, blood clotting, inflammation, immunity, and energy production are all responsive to the ratio of unsaturated fats to saturated fats, and the higher this ratio is, the greater the probability of harm there is.
*) PUFA is safe unless …
PUFA is readily oxidized when incorporated in tissues. 48 hours.

The toxicity of PUFA is variable and depends on the capacity of your liver to eliminate / neutralize Oxl (oxidized cholesterol, namely oxidized LDL).

The liver has a powerful lipid metabolism capacity but is limited by the amount ingested. The liver continuously removes the Ox-LDL in the circulation…
Make a search with: Elimination of Ox-LDL through the liver by Lox-1.
Note: Safe until you don’t overload the liver and your metabolism “burns” the right dose of PUFA. The dose is very low and we must take into account if there is the presence of SFA or not when ingesting PUFA. More deleterious without SFA. I take some coconut oil (1 tsp) with my white fish.
PS: Everyone will not agree with each other on this subject.
Useful links:

Unsaturated Vegetable Oils: Toxic
http://www.raypeat.com/articles/articles/unsaturated-oils.shtml
Effets anti thyroïde des oméga-3
http://mirzoune-ciboulette.forumactif.org/t1388-huile-de-poisson-et-effet-sur-la-thyroide#15791
*) Vitamin E function and requirements in relation to PUFA
Daniel Raederstorff et al. Br J Nutr. 2015. doi: 10.1017/S000711451500272X
=> 20 mg Vit E for 10 gr PUFA
If 10 gr PUFA (1.5 W3 LA and 8.5 gr W6 ALA): (1.5 x 3) + (8.5 x 2) = 18.5 mg Vit E
Unsaturated Vegetable Oils: Toxic
http://www.raypeat.com/articles/articles/unsaturated-oils.shtml
Excerpt 1 from: Arachidonic acid causes an uncoupling effect and inhibits cellular respiration
https://www.sciencedirect.com/science/article/pii/S0891584999000349
“It is shown that arachidonic acid causes an uncoupling effect under state 4 respiration of intact mitochondria as well as a marked inhibition of uncoupled respiration.
Excerpt 2 from: Unsaturated Vegetable Oils: Toxic
http://www.raypeat.com/articles/articles/unsaturated-oils.shtml
To defend the seeds from the animals that would eat them, the [PUFA]-oils block the digestive enzymes in the animals' stomachs.
Their tendency to oxidize is very great. These oxidative processes can damage enzymes and other parts of cells, and especially their ability to produce energy.
The enzymes which break down proteins are inhibited by unsaturated fats, and these enzymes are needed not only for digestion, but also for production of thyroid hormones, clot removal, immunity, and the general adaptability of cells. The risks of abnormal blood clotting, inflammation, immune deficiency, shock, aging, obesity, and cancer are increased. Thyroid and progesterone are decreased. Since the unsaturated oils block protein digestion in the stomach, we can be malnourished even while "eating well."

samson

@Uroš niacin can help to lower oxidative stress during fat loss

Uroš

@herayclitus nice, thanks.

Uroš

@LucH thank you for the "in depth" reply.