Niacinamide destroys fear and anxiety
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Niacinamide, 1500mg per day, greatly reduces fear and anxiety by boosting GABA signalling.
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How long does it take to work?
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@PeatPerspective
Starting 2 or 3 weeks ago i went on another Niacinamide protocol, one that i was going to actually stick with this time. At doses of 150-200mg twice a day, sometimes three times just to see if it would keep me awake at night.I felt the calming effects the first day, as i had in the past, less than an hour after the dose. Now imagine coupling this with Taurine, Glycine and Magnesium, say goodbye to stress.
I recall in the past getting a little sleepy from it, and perhaps some sugar cravings, but not this time around.
I was going to do a standard Niacin protocol but postponed it for some time in the future.
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@BioEclectic said in Niacinamide destroys fear and anxiety:
I was going to do a standard Niacin protocol but postponed it for some time in the future.
Useful info:
*) Haidut posted:
Niacinamide acts an antagonist to serotonin
In addition, Vitamin E and zinc also lower prolactin:
Effect of vitamin E therapy on sexual functions of uremic patients in hemodialysis. - PubMed - NCBI
Zinc: an inhibitor of prolactin (PRL) secretion in humans. - PubMed - NCBI
*) Chris Masterjohn said:
You’ll need more glycine to buffer excess niacin side-effects.
DON'T Use Niacin to Buffer Excess Methyl Groups
https://www.youtube.com/watch?v=ahCznKoG-Zo
No need to listen to.
Excerpt:
4.05”: Niacin is used as a drug. Glycine is used as a nutrient.
4.50”: You’re artificially changing the system by adding extra niacin. You can easily create a deficiency by adding extra niacin into the mix (pointing at the brain with his fingers): Suddenly over-methylation swung into under-methylation, and you need sth to fix that. You’re then relying on your own wisdom instead of the wisdom of the system (homeostasis, note’s editor).
Glycine is a normal physiological methyl group buffer.
*) Lucenzo01 said in: Niacin, Niacinamide and Methylation
https://raypeatforum.com/community/threads/niacin-niacinamide-and-methylation.23050/post-379424
Excess niacin is glycinated, excess niacinamide is methylated.
So I repeat [Lucenzoo1 speaking], if Lynch and others claim that niacin is methylated, how does it happen?
*) Ray PEAT recommended 125mg B3 3 or 4 times daily (200-500mg/day) and he said it's probably safe up to 1000 mg/day.
*) Endpoint
=> Make your own advice
Note 1: It’s not because it’s going fine for 2 or 3 weeks, you won’t change the whole physiological balance.
Note 2: I take 100 mg niacinamide, with B1 B2 B6 PLP and 500 mg TMG 2x/d. With staples when taking high dose B6 PLP (to avoid side-effects on acetylcholine). -
@LucH Thanks!
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@BioEclectic Very helpful thank you! When I took high dose Niacinamide my blood pressure got super low. Making me feel more anxious. Dropping down to 50mg at each meal
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@LucH Thank you as always. I'll re-research Niacin to take note of possible factors. That RP forum thread you linked has another useful link to a Niacin discussion at the PhoenixRising forum: https://forums.phoenixrising.me/threads/does-methyl-absorbing-niacin-neutralise-methyl-supplements.54918/#post-919667
@PeatPerspective, you're very welcome. A steady dose of 50mg with most meals would probably bring much of the benefits we've read about Niacinamide, especially if you keep it up for a while. It makes for interesting research too, at the RP forum i do a title only search using the word Niacinamide, so many potential benefits are posted, especially by Haidut.
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@BioEclectic said in Niacinamide destroys fear and anxiety:
I'll re-research Niacin to take note of possible factors.
Side effects with high dose B3 when taking 500 – 1 500 mg.
Health Risks from Excessive Niacin
https://ods.od.nih.gov/factsheets/Niacin-HealthProfessional/ -
@LucH Thank you!
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@LucH
With standard Niacin i was now considering 50-100mg twice a day. I would try to hold that steady for a couple of months. Then afterward only two or three times a week and alternating with my mainstay Niacinamide.Getting that dose semi-precise may be a challenge but there's plenty of time to figure it out before i begin.
Thank you again @LucH
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