Thymus health
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@Mauritio said in Thymus health:
@cs3000 said in Thymus health:
another one, 6% protein calories vs 20%
4 calories in 1 gram of protein
at 2500 calories human equiv ~35grams daily gave a way smaller thymus vs 125grams protein daily with extra carbs replacing the lost protein,87% lower thymus weight from 35g protein
Not sure how to make sense of the above two statements . Other than low protein seems to be more detrimental than FGF21 os beneficial for thymus health.
Dare to think.
My X:
x.com/Metabolicmonstr -
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@TexugoDoMel awesome. Thanks for sharing !
Dare to think.
My X:
x.com/Metabolicmonstr -
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The thymus can produce pregnenolone and cortisol. Similarly to the andrenal glands.
Just haven't found info on how significant this hormone production is. -
@Mauritio
the fgf21 is largely through mtor , (rapamycin abolished effect)
https://pubmed.ncbi.nlm.nih.gov/39972173/
still hindered when on low protein with the increase so yeah guess its weaker more of a support (when they knocked out fgf21 in the young mice in study you posted their thymocyte numbers didnt change). something can happen in aging with mtor signalling still high but fails to create anabolic response i guess need boththis one affected thymus of young mice sort of, in some composition changes. and showed fgf21 is maintained high in thymus regardless of regular eating (protein intake)
https://www.nature.com/articles/s41598-017-00349-8
(also a bit in the liver , because these 2 are always vulnerable needing protection & to regenerate more & more often)Its a pretty wide comparison , i'd guess ~60g protein wouldnt show a loss. or adding some leucine
@cs3000 said in Thymus health:
~35grams daily gave a way smaller thymus vs 125grams protein daily with extra carbs replacing the lost protein,87% lower thymus weight from 35g protein
Not sure how to make sense of the above two statements . Other than low protein seems to be more detrimental than FGF21 os beneficial for thymus health.
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@cs3000 said in Thymus health:
the fgf21 is largely through mtor , (rapamycin abolished effect)
https://pubmed.ncbi.nlm.nih.gov/39972173/
still hindered when on low protein with the increase so yeah guess its weaker more of a support (when they knocked out fgf21 in the young mice in study you posted their thymocyte numbers didnt change). something can happen in aging with mtor signalling still high but fails to create anabolic response i guess need boththis one affected thymus of young mice sort of, in some composition changes. and showed fgf21 is maintained high in thymus regardless of regular eating (protein intake)
Makes sense!
It seems that FGF21 can up or down regulate mtor depending on tissues.In this study FGF21 lowered mtor in the liver
https://pubmed.ncbi.nlm.nih.gov/26926384/And in this study in cancer cells it lowered it as well.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7985321And the strong expression of FGF21 in thymus tissue is a brilliant adaption of the body to a low protein diet. Since low protein weakens immunity via lowered mtor, but it strongly increases FGF21 in thymus which activates mtor locally and improves immunity.
But it's wild how big the difference in FGF21 is between different tissues! Nothing comes close to the thymus.
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10-HDA from Royal jelly restores thymus health in immunosuppressed mice.
Dosage was quite high . HED~ 30-60g
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The negative effects of androgens on thymus health, Sometimes observed, are medicated through the Glucocorticoids receptor.
Maybe aromatization of testosterone,/ estrogen activates it."The androgen-induced thymic involution was dependent on GC action, because this was completely absent in mice lacking GC receptor (GR) expression specifically in thymocytes. We provide here an unrecognized mechanism how androgens contribute to thymic involution by stimulating local synthesis and release of GCs in the thymus."
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@TexugoDoMel, thanks for the tables. Interesting, indeed.
Do you have a reference paper for the tables?
