The Impact of Alpha-Ketoglutarate (AKG) on Skeletal Muscle Health and Exercise Performance

DavidPS

@bio3nergetic - Arginine α-ketoglutarate (AAKG) containing supplements have been associated with adverse effects requiring hospital admission.

Adverse effects associated with arginine
α-ketoglutarate containing supplements (2009)

Risk assessment of "other substances"
– L-arginine and arginine alpha-ketoglutarate (2016)

Most the recent work has been performed using calcium α-ketoglutarate (Ca-AKG) which is more expensive but not life-threatening.

bio3nergetic

Thanks @DavidPS I am some how not surprised! Arginine anything is a major risk.

Mauritio

Interesting. There's some good studies on AKG longevity and metabolism .
I think it's worth a try, have you tried it ? @davidps

DavidPS

@Mauritio - Yes I have tried AKG as a supplement and I still use it. I have not noticed any specfic muscle and exercise performance benefits. I am trying to stay healthy. AKG is formed in gut and I am not willing to assume that my gut microbiome is not the weakest link in my health.
Alpha-Ketoglutarate, the Bacteriome, Protein Metabolism, and Longevity (2026)

AKG is part of the Krebs cycle.

Wiki states that the body has a way to handle excess. See:
https://en.wikipedia.org/wiki/Α-Ketoglutaric_acid

Here is another general reference from 2016.

Alpha-Ketoglutarate: Physiological Functions and Applications

Mauritio

@DavidPS Thanks

Mauritio

α-Ketoglutarate Is a Circulatory Exercise Factor That Promotes Learning and Memory Recall and Has Antidepressant Properties

Increase in PGC-1a and BDNF

https://pubmed.ncbi.nlm.nih.gov/40248276/

Mauritio

α-Ketoglutarate promotes amino acid depletion and suppresses B-cell lymphoma growth and development

https://pubmed.ncbi.nlm.nih.gov/40700634/

DavidPS

@Mauritio - Thanks for the link. I started taking AKG in 2020 after I read that it restores hair color in some people. It did not work for me but it is still on my short list of supplements.

Mauritio

@DavidPS how much are you taking everyday ?

DavidPS

@Mauritio - I take a gram which I split into 2 doses.

Mauritio

@DavidPS Ok thanks. Have you ever posted your daily supplement stack ? Would be interesting to read.

DavidPS

@Mauritio - I am a whole foods type of person. I encourage others to get their nutrients from food.