Random, interesting studies
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Strong pro-sexual effects of Massularia acuminata. Also increases Testosterone on the highest dose.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3022175/#sec3
Increases testosterone, testicular cholesterol and almost triples the testicle- body weight ratio.
https://pubmed.ncbi.nlm.nih.gov/18602232/Mixed results depending on dosage
https://pubmed.ncbi.nlm.nih.gov/21951198/Might cause elevation in liver enzymes.
https://www.researchgate.net/publication/375867305_Effects_of_Aqueous_Stem_Extract_of_Massularia_Acuminata_on_Some_Liver_Function_Indices_of_Male_RatsIn this study it seems liver protective
Seems safe in lower doses
https://www.researchgate.net/publication/356879871_HAEMATOLOGICAL_BIOCHEMICAL_AND_HISTOLOGICAL_TOXICITY_OF_THE_ETHANOLIC_EXTRACT_OF_MASSULARIA_ACUMINATA_G_DON_BULLOCK_EX_HOLY_RUBIACEAE_STEMS_IN_RAT -
Bulbine natalensis
Is another interesting candidate.
Increases testosterone 3-4bfold, lowers estrogen and increases progesterone slightly. Doesn't affect prolactin.
This is only in lower doses (this study 25 /50mg/kg dose) at 100mg/kg it had negative effects.
https://pubmed.ncbi.nlm.nih.gov/19410284/Might cause some slight atrophy in liver and kidneys, mostly at higher doses.
https://pubmed.ncbi.nlm.nih.gov/19735182/Completely safe in human males , 28 days, 650mg/d
https://pmc.ncbi.nlm.nih.gov/articles/PMC3500755/ -
Bees Wax + Policosanol
The alcoholic fraction of Bees wax /honeycomb is policosanol. Here's a threat on policosanols benefits:
https://lowtoxinforum.com/threads/the-policosanols-thread.35360/Beeswax alcohol (BWA), a mixture of six long-chain aliphatic alcohols (tetracosanol, hexacosanol, octacosanol, triacontanol, dotriacontanol, and tetratriacontanol)
https://pmc.ncbi.nlm.nih.gov/articles/PMC11672924/
I never thought about it like that. Probably pretty silly to not eat the honey comb . Until about 1900 it was common to do that .
How much policosanols is in bees wax / honeycomb?
It seems to be about 1%.
That's a big dose. 100mg from a 10g dose of honey comb/wax .
In this study in German they tested several different bees wax samples from Switzerland, China, Canada and Brasil and they all contained 1% of fattyalcohols (german: "Fettalkohole") .
So a 1% mark of policosanol seems to be globally reliable.
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@Mauritio had potential but we cant digest the wax / comb so wouldnt go into system, high in sugarcane wax too , i looked it up if you could extract it by melting the beeswax in hot water. but policosanol form in beeswax is an ester not bioavailable for us until processed / hydrolysed
as a supplement its a good effect on helping lower atherosclerosis without the extra fuckery statins give (and actually shows regression combined with low fat diet) 10mg - 40mg is about the same effect for that (the content of the policosanol matters needs enough octacosanol, and if its ester form probably not absorbed much) (octacosanol is most active part, #3 in https://cs3001.substack.com/p/some-health-finds-3) -
@cs3000 Oh damn so close and yet so far
Do you have a source for it beeing indigestible for us ? -
For those saying DNP is safe and only careless people die from it.
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"This study concludes that the dietary recommendation to avoid consuming coconut oil due to its effects on lipid parameters is not justified,"
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@Mauritio said in Random, interesting studies:
@cs3000 Oh damn so close and yet so far
Do you have a source for it beeing indigestible for us ?@Mauritio @cs3000 i have eaten honey comb multiples Times, a good part of the wax do not melt in the mouth even if you chew it very long, and the part that you swallow often end up as solid flakes in your intestins that cause intestinal irritations and nightmare if you swallow alot. Comb from more recent hives and recently harvested Can be much softer. If you look at hunters gatherers eating honey comb in documentary they spit back the comb. part of beekeepers use plastic/synthetic materials as a base for bees to build the hive on, therefore some honey comb contain a sheet of plastic/synthetic materials in the middle. It is possible you absorb part of what is in the wax, as wax that is colored like orange will end up white/yellowish if you chew it alot even if you dont swallow it
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@Mauritio
one in dogs vs birds (fig 2 , its not policosanol tho general
fatty acid esters absorbed a little but the fatty alcohol ester didnt https://www.researchgate.net/publication/21739344_Comparative_aspects_of_lipid_digestion_and_absorption_Physiological_correlates_of_wax_ester_digestionbut looked a bit further for specific, rats can digest even more of it if its esterified specific to oleic acid
but thats synthetic esterification not bound with oleic acid normally https://grasasyaceites.revistas.csic.es/index.php/grasasyaceites/article/view/1388 , couldnt find if humans could absorb some but theres a case of a women with gastric blockage who ate a lot of honeycomb so at least a lot goes undigested
https://pmc.ncbi.nlm.nih.gov/articles/PMC2740191/#s02
was still worth posting your post now i know more about it & wouldnt have@Mauritio said in Random, interesting studies:
for it beeing indigestible for us ?
study from that megathread showing good anti blood clotting property of policosanol https://pubmed.ncbi.nlm.nih.gov/9425618/
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@cs3000 if its extracted from sugarcane wax its mostly the free form policosanol with high % octacosanol and more digestible https://pubmed.ncbi.nlm.nih.gov/12423895/ maybe 7% as esters in the wax. has b-sitosterol which is anti androgen but <1% of the wax
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@cs3000 said in Random, interesting studies:
@Mauritio had potential but we cant digest the wax / comb so wouldnt go into system, high in sugarcane wax too , i looked it up if you could extract it by melting the beeswax in hot water. but policosanol form in beeswax is an ester not bioavailable for us until processed / hydrolysed
as a supplement its a good effect on helping lower atherosclerosis without the extra fuckery statins give (and actually shows regression combined with low fat diet) 10mg - 40mg is about the same effect for that (the content of the policosanol matters needs enough octacosanol, and if its ester form probably not absorbed much) (octacosanol is most active part, #3 in https://cs3001.substack.com/p/some-health-finds-3)Doesn’t the hot water cause hydrolysis ?
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Anybody tried bees bread ?
In this study it did wonders for steroid health.
They gave mice on a HFD about 5-7g(HED) of bees bread and it completely rescued the levels of their steroidogenic enzymes.
Not only that, in many cases, giving them bees bread, increased the values above the normal control group.Testosterone was increased by about 60% above control levels.
StaR mRNA levels doubled !
Unfortunately estrogen was increased as well, but only to the level of the control group not above that.
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@Mauritio said in Random, interesting studies:
Anybody tried bees bread ?
I did, it Can taste much better than basic honey comb that has only wax and honey, basic honey comb is often to acidic and taste aint the best in most case compare to some honey in jar and some beesbread
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@Mauritio honey /most bee products /chyrsin rich foods generally increase testosterone.
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@alfredoolivas said in Random, interesting studies:
Doesn’t the hot water cause hydrolysis ?
apparently too slow by itself so they do extra processing
@Mauritio said in Random, interesting studies:
Anybody tried bees bread ?
In this study it did wonders for steroid health.nice , & a potent effect really fast in a diabetes model. normalised by 3 days. fastest effect ive seen
STZ model = destruction of pancreas cells so i guess its most relevant to type 1 , or if someone with type 2 has lacking pancreatic islet cells too as part of their problem. full damage was done initially so shows good effect
they used an extract ~30mg polyphenols 5mg flavanols per gram so maybe ~ 5g bee bread for 1g of extract
composition varies a lot by location if it was the polyphenols giving most of the effect even in same country by region,
theirs was high inkaempferol-3-O-di-rhamnosideIsorhamnetin-O-hexosyl-O-rutinosidehttps://pmc.ncbi.nlm.nih.gov/articles/PMC8264221/#sec7
and if you believe the results,
they showed its acute effect (didnt lower blood sugar when not elevated)
Which is odd. because its not lowering glucose in non diabetic rats so its not acting like insulin right? unless things are effectively counteracting it in the normal group because it would be crashing otherwise from insulin secretion. (at 3hrs in the DW group they had lower blood sugar though 84 vs 92)
unlikely enough islet cells left from the damage to stimulate insulin secretion for such a drastic change in both of the groups, which is what GLB doe? idk maybe there is but they're clearly wrecked from such high glucose at 0hr. 3 hours isnt enough time to regenerate the islet cell damage -
@cs3000 said in Random, interesting studies:
apparently too slow by itself so they do extra processing
Could I finely dice it up and put it in a pot of boiling water for 15 minutes, whilst it remains boiling for the entire 15 minutes? would that be effective?
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@alfredoolivas i'd guess it takes a lot longer still but not sure ,
if youre interested in it for the octacosanol sugarcane wax is better only need a little already in a good form https://bioenergetic.forum/post/47406 supplements are around tho -
Again, TLR 4 /Endotoxin implicated inInfections, not just bacterial ones, but also viral.
"TLR4-dependent viral entry was further validated by an anti-TLR4 antibody-mediated blocking experiment. It was noticed that TLR4 is necessary for the early events of viral infection, especially during the attachment and entry stages."
https://pmc.ncbi.nlm.nih.gov/articles/PMC10157217/
Endotoxin might not just be implicated in viral entry, but long term consequences of viruses .
The drug larazotide is being researched for long covid symptoms. It basically works in a way that it prevents endotoxin from entering circulation . -
@cs3000 said in Random, interesting studies:
@Mauritio
one in dogs vs birds (fig 2 , its not policosanol tho general
fatty acid esters absorbed a little but the fatty alcohol ester didnt https://www.researchgate.net/publication/21739344_Comparative_aspects_of_lipid_digestion_and_absorption_Physiological_correlates_of_wax_ester_digestionbut looked a bit further for specific, rats can digest even more of it if its esterified specific to oleic acid
but thats synthetic esterification not bound with oleic acid normally https://grasasyaceites.revistas.csic.es/index.php/grasasyaceites/article/view/1388 , couldnt find if humans could absorb some but theres a case of a women with gastric blockage who ate a lot of honeycomb so at least a lot goes undigested
https://pmc.ncbi.nlm.nih.gov/articles/PMC2740191/#s02
was still worth posting your post now i know more about it & wouldnt have@Mauritio said in Random, interesting studies:
for it beeing indigestible for us ?
study from that megathread showing good anti blood clotting property of policosanol https://pubmed.ncbi.nlm.nih.gov/9425618/
Seems right. For some reason birds seem to be good at it. Humans not. Such a shame.
And interesting studies you posted on Bee bread. Quite the strong effect indeed.
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Im not convinced that low protein is dangerous and catabolic, mid - long term in people under 65.
I recently posted a study showing 5 weeks of 8% protein in the diet did not cause muscle loss. After which someone said that isnt long enough .
Now here's a study showing that 12 weeks of a very low 0.4g/kg/d, ~5%protein diet does not lower basal muscle protein synthesis!
https://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0137183It seems to come down to age as well.
Here it gets interesting: if you're under 65 and eating a high protein diet, that is strongly associated with death, cancer and diabetes . Over 65 it seems to be protective !"...aged 50–65 reporting high protein intake had a 75% increase in overall mortality and a 4-fold increase in cancer and diabetes mortality..."
https://pmc.ncbi.nlm.nih.gov/articles/PMC3988204/Not sure why. Low protein diets can lead to lower thymus weight, as seen in this study (https://www.scielo.br/j/bjmbr/a/MGBdr7CsJTMQrf7Bhjbdv3z/?lang=en)
And older people are more susceptible to infections and chronic inflammation .So maybe after 65 the increase
in Protein and inflammatory amino acids is worth the trade off, for increased immunity and suppression of inflammation .
Maybe it's simply the lesser of 2 evils at that point .
What do you guys think?Dare to think.
My X:
x.com/Metabolicmonstr
