Random, interesting studies

Mauritio

@Lejeboca yes I saw that one too but hadn't clicked on it. Thanks for sharing.

Mauritio

Sorbitol

I'd be careful with sorbitol. The issue with sorbitol is that it is often made with a nickel catalyst, which leaches into the endproduct.

" The Cr/Fe promoted system exhibits the highest activity but the Fe leaches from the catalyst into the reaction mixture. Moreover, this catalyst deactivates after successive runs. For all Raney-type Ni catalysts leaching of Ni in the product mixture occurs."
https://www.sciencedirect.com/science/article/abs/pii/S0920586103000403?via%3Dihub

Although Ray said a little is ok:

Post 28 Title: Bryan · Feb 4, 2013 at 5:00 PM Author: Bryan Post Content:

Me: Is sorbitol o.k. to eat? I got some gummy bears that have it in them.

Peat: A little is o.k.

Mauritio

Papaya/Papain

Papain reverses the effects of a high fat diet in mice. The mice getting Papain, did not gain more weight than the mice on a normal control diet.
Papain even lowered visceral fat content slightly below the control group.
It lowered liver enzymes, triglycerides, adipogenic and inflammatory Markers.
It also drastically upregulated AMPK, similarly to aspirin, biotin or infrared light.

https://pmc.ncbi.nlm.nih.gov/articles/PMC8468764/

Potent Fibrinolytic, Anticoagulant, and Antithrombotic Effects of Papain
https://pubmed.ncbi.nlm.nih.gov/38069092/

Lowers the number of mast cells and inflammatory cytokines
https://pubmed.ncbi.nlm.nih.gov/39199175/

Papain has anti-artherosclerotic effect. Lowers COX-2, PGE2 and other cytokines.
https://pubmed.ncbi.nlm.nih.gov/36947095/

Papaya extract increases testosterone and sperm health, damaged by alcohol.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7099107/#Sec17

Mauritio

Oyster peptides increase testosterone
https://pmc.ncbi.nlm.nih.gov/articles/PMC10563733/

alfredoolivas

@Mauritio Seems to be an affordable experiment to try: a kg costs only 90 dollars

https://enzymes.bio/product/papain-200000-u-g-food-grade-biological-enzyme/

Mauritio

@alfredoolivas why would you want a KG of it to experiment with it ??

alfredoolivas

@Mauritio I don't want to experiment with it, I was just pointing it out because

1.) Animal studies often use large doses, that aren't feasable with dosages found in OTC supplements
2.) Raw materials are rarely food / USP grade, and this was food grade. They also can be expensive and not sold to private individuals.

So I was letting you know about it, incase you wanted to try it.

lobotomize

@alfredoolivas tried to buy lactase from them. They list a goverment building as their site of operations. Probably a scam website. Fucking hate eu chem restrictions

alfredoolivas

@lobotomize Good detective work

CrumblingCookie

@Mauritio said in Random, interesting studies:

Papain even lowered visceral fat content slightly below the control group.
It lowered liver enzymes, triglycerides, adipogenic and inflammatory Markers.
It also drastically upregulated AMPK, similarly to aspirin, biotin or infrared light.

https://pmc.ncbi.nlm.nih.gov/articles/PMC8468764/

Nice find. It lowers PPARγ (decreased lipogenesis). By the looks of it increasing CaMKK, LKB1, Sirt1 (which of course are all in reciprocal interaction with AMPK) it probably also works via enhanced degradation of intracellular lipid droplet accumulations, i.e. more autophagy.
Bookmarked for later.