Random, interesting studies

alfredoolivas

@Mauritio Menthol, Camphor, Menthone and Eucalyptus, all are terpenoids known for their "cooling" effect, and are completely saturated- Camphor and Eucalyptus are even saturated cages, similar to Adamantane. Very interesting to me.
I would love to see if their is some overlap in their origin, structure or effects

Mauritio

@alfredoolivas yeah very interesting!
Look at the progesterone like effect of the studies I just edited in.
If they are indeed saturated molecules that makes an estrogenic effect even less likely .

Btw trump just brought back menthol cigarettes , so that's good timing

alfredoolivas

@Mauritio Peppermint oil is 30-50% menthol, 15-30% menthone and 5-10% eucalyptol. So peppermint oil could be a vehicle to deliver these substances.

Mauritio

@alfredoolivas yes. I'm just not sure about potential estrogenic or anti DHT effects. But I haven't seen anything conving, that would stop me from consuming it infrequently .

DavidPS

I purposefully stay away from peppermint.

Effects of peppermint teas on plasma testosterone, follicle-stimulating hormone, and luteinizing hormone levels and testicular tissue in rats (2004)

Mauritio

@DavidPS yeah that is the most convincing study i've seen so far the dosage also wasn't excessively high

alfredoolivas

@Mauritio Well progesterone does the same; inhibits LH and FSH, and is therefore anti-androgenic. Unless peppermint oil is estrogenic, it may be a good proxy for progesterone.

DavidPS

Mauritio

@alfredoolivas said in Random, interesting studies:

@Mauritio Well progesterone does the same; inhibits LH and FSH, and is therefore anti-androgenic. Unless peppermint oil is estrogenic, it may be a good proxy for progesterone.

Peppermint actually increased LH /FSH, unlike Progesterone.

I want to mention that the amount of menthol you get from tea is about ten times less than you get from the essential oil. and menthol seems to be the deciding metabolic factor here.
menthol actually has antiprolactin effects as i posted above so i'm not sure if anti - testosterone effects would be seen with the essential oil which is mostly Menthol.

cs3000

This post is deleted!

cs3000

@DavidPS high amounts 40mg/kg peppermint caused white matter dmg vs 10mg/kg which didnt show it for this dmg , rats https://www.sciencedirect.com/science/article/abs/pii/0378427483901212

But the menthol has some liver toxicity at dopamine doses i think, shows liver protection caused by other things but can cause liver changes https://doi.org/10.1016/0378-4274(83)90120-0

when i tried menthol for the dopamine & temp effect i tried it through the skin , noticed some liver pain after a bit ~1g. which i never get otherwise

DavidPS

@cs3000 - thanks for the additional information.

Mauritio

@cs3000 thanks interesting . It seems save enough for a short duration or infrequent use.
I also noticed some dopaminergic benefits from nebulizing peppermint oil . I guess the dose there should be very low.

The liver pain might also come from it decreasing peristalsis and thus bile not being excreted fast enough and reabsorbed...