Random, interesting studies

DavidPS

@Mauritio - Have you considered food sources?

CrumblingCookie

@Mauritio - Have you considered food sources?

Foods Ranked 1 - 20 With Theobromine

My expectations for such a list were low but nevertheless beaten by such impressive stubborness:
It's only variations of cocoa and chocolate!
Now we know of your imaginations of a well-varied, balanced diet. Made me chuckle.

Mauritio

@DavidPS yes, I like chocolate, but it contains too much heavy metals.
Has anybody tried theobromine as a supplement ?

DavidPS

@Mauritio - thank you for bringing theobromine to my attention. I plan on trying it after things settle down after the holidays.

I am anticipating that theobromine will stress my nervous system in much the same way that caffeine stresses it and I plan on timimg my daily doses much like I do with coffee.

Health benefits and mechanisms of theobromine (2024)

Highlights

• Theobromine, a member of the methylxanthine class of compounds, has multiple potential health benefits.

• Theobromine acts as a non-selective antagonist of adenosine receptors, operates as a competitive and non-selective inhibitor of phosphodiesterases, and disrupts the activity of poly(ADP-ribose) polymerase 1 to exert its physiological functions. Theobromine, due to its low toxicity and versatility, can be employed as an additive in functional foods.

LucH

@DavidPS said in Random, interesting studies:

I am anticipating that theobromine will stress my nervous system

Mind theobromine if weak cardia muscle (acid reflux)

Mauritio

@DavidPS you're welcome.
Theobromine is supposed to be less stimulating for the CNS than caffeine.

Here's another study where it strongly increased tyrosine hydroxilase and dopamine receptors in a mouse model of ADHD.

https://www.researchgate.net/publication/380300570_Theobromine_improves_hyperactivity_inattention_and_working_memory_via_modulation_of_dopaminergic_neural_function_in_the_frontal_cortex_of_spontaneously_hypertensive_rats

Mauritio

This post is deleted!

Mauritio

Aspirin alleviates fibrosis in mouse model. Hed~600mg.

https://pmc.ncbi.nlm.nih.gov/articles/PMC12226408/

Mauritio

Effect of different foods on gallbladder volume/emptying

If you suffer from stuck bile/ gallbladder issues this might be an interesting study.

You can see some interesting observations in the above images
C is a yoghurt drink. In D they just added 3g of protein to the yoghurt drink and increased gallbladder emptying by about 40% .
Adding just 80mg of Curcumin (E) to the yoghurt more then doubled gallbladder volume change. Almost as good as that is coffee (F), even though it contains very little fat.
And then among the best is semi skimmed milk (H).

So I wonder if you could have added benefits on gallbladder emptying by putting milk in your coffee and maybe adding some Curcumin (80mg is very little)?

Anyhow, as the image below shows very small amounts of fat are actually needed to stimulate CCK. And between 6 and 10g there was alnost no difference. So around 6g might be the best calorie /CCK ratio.
Just having a teaspoon of olive oil should be enough. And I can agree with that from my experience

Another interesting observation was that fasting gallbladder volume was very different from person to person. There was a 5x difference from the person with the lowest to the highest gallbladder volume.

Source:
https://pmc.ncbi.nlm.nih.gov/articles/PMC3898429/#bib23

Mauritio

"Increasing coffee consumption by one cup per day was associated with a 15% reduction in liver cancer risk (RR 0.85; 95% CI 0.82 to 0.88)."

https://pmc.ncbi.nlm.nih.gov/articles/PMC5622710/

Coffee lowers risk for gallstones

"...those with coffee intake of >6 cups daily had 23% lower risk of GSD compared to individuals without coffee intake [hazard ratio (HR) = 0.77 (95% confidence interval: 0.61-0.94)]."
https://pubmed.ncbi.nlm.nih.gov/31486166/

Mauritio

Here's another study showing gallbladder contraction after drinking coffee. This is probably part of the reason it helps people go to the bathroom.

Coffee was far superior than a salt solution of the same amount.
And decaffeinated coffee was slightly less effective.

"An average gallbladder contraction of 33 +/- 7% was observed after 165 mL regular coffee and 29 +/- 10% after 165 mL decaffeinated coffee, whereas after 165 mL sodium chloride the contraction was only 10 +/- 12%."

https://pubmed.ncbi.nlm.nih.gov/2393014/

lobotomize

haribo and most gummies have beeswax

Mauritio

@lobotomize what does that have to do with anything ?