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    Random, interesting studies

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    • C Offline
      CrumblingCookie @DavidPS
      last edited by CrumblingCookie

      @Mauritio - Have you considered food sources?

      Foods Ranked 1 - 20 With Theobromine

      My expectations for such a list were low but nevertheless beaten by such impressive stubborness:
      It's only variations of cocoa and chocolate!
      Now we know of your imaginations of a well-varied, balanced diet. Made me chuckle.

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      • MauritioM Offline
        Mauritio @DavidPS
        last edited by

        @DavidPS yes, I like chocolate, but it contains too much heavy metals.
        Has anybody tried theobromine as a supplement ?

        DavidPSD 1 Reply Last reply Reply Quote 0
        • DavidPSD Offline
          DavidPS @Mauritio
          last edited by DavidPS

          @Mauritio - thank you for bringing theobromine to my attention. I plan on trying it after things settle down after the holidays.

          I am anticipating that theobromine will stress my nervous system in much the same way that caffeine stresses it and I plan on timimg my daily doses much like I do with coffee.
          d21a095e-fd11-440c-8799-21d3c70c0353-image.png

          Health benefits and mechanisms of theobromine (2024)

          Highlights

          • Theobromine, a member of the methylxanthine class of compounds, has multiple potential health benefits.

          • Theobromine acts as a non-selective antagonist of adenosine receptors, operates as a competitive and non-selective inhibitor of phosphodiesterases, and disrupts the activity of poly(ADP-ribose) polymerase 1 to exert its physiological functions. Theobromine, due to its low toxicity and versatility, can be employed as an additive in functional foods.

          Don't separate work and play; it is all play. šŸ‘€
          ā˜‚ļø

          LucHL MauritioM 2 Replies Last reply Reply Quote 1
          • LucHL Offline
            LucH @DavidPS
            last edited by

            @DavidPS said in Random, interesting studies:

            I am anticipating that theobromine will stress my nervous system

            Mind theobromine if weak cardia muscle (acid reflux)

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            • MauritioM Offline
              Mauritio @DavidPS
              last edited by

              @DavidPS you're welcome.
              Theobromine is supposed to be less stimulating for the CNS than caffeine.

              Here's another study where it strongly increased tyrosine hydroxilase and dopamine receptors in a mouse model of ADHD.

              https://www.researchgate.net/publication/380300570_Theobromine_improves_hyperactivity_inattention_and_working_memory_via_modulation_of_dopaminergic_neural_function_in_the_frontal_cortex_of_spontaneously_hypertensive_rats

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              • MauritioM Offline
                Mauritio
                last edited by Mauritio

                This post is deleted!
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                • MauritioM Offline
                  Mauritio
                  last edited by

                  Aspirin alleviates fibrosis in mouse model. Hed~600mg.

                  https://pmc.ncbi.nlm.nih.gov/articles/PMC12226408/

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                  • MauritioM Offline
                    Mauritio
                    last edited by Mauritio

                    Effect of different foods on gallbladder volume/emptying

                    If you suffer from stuck bile/ gallbladder issues this might be an interesting study.

                    1000024990.jpg

                    1000024992.png

                    You can see some interesting observations in the above images
                    C is a yoghurt drink. In D they just added 3g of protein to the yoghurt drink and increased gallbladder emptying by about 40% .
                    Adding just 80mg of Curcumin (E) to the yoghurt more then doubled gallbladder volume change. Almost as good as that is coffee (F), even though it contains very little fat.
                    And then among the best is semi skimmed milk (H).

                    So I wonder if you could have added benefits on gallbladder emptying by putting milk in your coffee and maybe adding some Curcumin (80mg is very little)?


                    Anyhow, as the image below shows very small amounts of fat are actually needed to stimulate CCK. And between 6 and 10g there was alnost no difference. So around 6g might be the best calorie /CCK ratio.
                    Just having a teaspoon of olive oil should be enough. And I can agree with that from my experience

                    1000024993.jpg


                    Another interesting observation was that fasting gallbladder volume was very different from person to person. There was a 5x difference from the person with the lowest to the highest gallbladder volume.
                    1000024994.jpg


                    Source:
                    https://pmc.ncbi.nlm.nih.gov/articles/PMC3898429/#bib23

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                    • MauritioM Offline
                      Mauritio
                      last edited by Mauritio

                      "Increasing coffee consumption by one cup per day was associated with a 15% reduction in liver cancer risk (RR 0.85; 95% CI 0.82 to 0.88)."

                      https://pmc.ncbi.nlm.nih.gov/articles/PMC5622710/


                      Coffee lowers risk for gallstones

                      "...those with coffee intake of >6 cups daily had 23% lower risk of GSD compared to individuals without coffee intake [hazard ratio (HR) = 0.77 (95% confidence interval: 0.61-0.94)]."
                      https://pubmed.ncbi.nlm.nih.gov/31486166/

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                      • MauritioM Offline
                        Mauritio
                        last edited by Mauritio

                        Here's another study showing gallbladder contraction after drinking coffee. This is probably part of the reason it helps people go to the bathroom.

                        Coffee was far superior than a salt solution of the same amount.
                        And decaffeinated coffee was slightly less effective.

                        "An average gallbladder contraction of 33 +/- 7% was observed after 165 mL regular coffee and 29 +/- 10% after 165 mL decaffeinated coffee, whereas after 165 mL sodium chloride the contraction was only 10 +/- 12%."

                        https://pubmed.ncbi.nlm.nih.gov/2393014/

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                        • lobotomizeL Offline
                          lobotomize
                          last edited by

                          haribo and most gummies have beeswax

                          MauritioM 1 Reply Last reply Reply Quote 0
                          • MauritioM Offline
                            Mauritio @lobotomize
                            last edited by

                            @lobotomize what does that have to do with anything ?

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