Random, interesting studies
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@dapose said in Random, interesting studies:
do you mess around with any phytol these days? Food or extract…
Ive ordered a food grade phytol supplement from Spain. Some herb, weed or terpene shops carry it.
I'm looking forward to trying it.Im kinda trying to recreate the 1/2nd generation Gonadin.I already take Diosgenin, now phytol . Next methyl oleate (might be able to accelerate PUFA detox).
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Rose hip
Rose hip increases thermogenesis, browning of white adipose tissue and UCP1 (a lot)
https://pubmed.ncbi.nlm.nih.gov/27980600/Rose hip extract lowers weight gain on a HFD, lowers visceral and liver fat.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3892499/It reduces atherosclerosis,oxidized LDL, total cholesterol and fibrinogen.
https://pubmed.ncbi.nlm.nih.gov/28399420/Daily intake of rosehip extract decreases abdominal visceral fat in preobese subjects
https://pmc.ncbi.nlm.nih.gov/articles/PMC4358417/#sec15
https://www.sciencedirect.com/science/article/abs/pii/S0924224416304277 -
@Mauritio
From Wikipedia, the free encyclopedia
Phytoprogestogens, also known as phytoprogestins, are phytochemicals (that is, naturally occurring, plant-derived chemicals) with progestogenic effects.[1][2]Relative to their phytoestrogen counterparts, phytoprogestogens are rare.[1] However, a number have been identified, including kaempferol, diosgenin (found in yam), apigenin (found in chasteberry),[1][3] naringenin, and syringic acid, among others.[2] In addition, 3,8-dihydrodiligustilide from Ligusticum chuanxiong is a potent progestogen (EC50 = 90 nM), whereas riligustilide is a weak progestogen (EC50 ≈ 81 μM).[4][5]
carrot salad by R.Peat delivers apigenin (phytoprogestogen) and absorbs estrogens
https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2024.1359176/full
" In mice, NAD+ levels can be elevated via treatment with apigenin, a natural flavonoid that inhibits the NAD+-consuming glycoprotein CD38."
Progesteron synthesis depends on NAD as a cofactor as well as myo-inositol synthase . -
@cedric said in Random, interesting studies:
From Wikipedia, the free encyclopedia
Phytoprogestogens, also known as phytoprogestins, are phytochemicals (that is, naturally occurring, plant-derived chemicals) with progestogenic effects.[1][2]Yes I have posted this very paragraph in this thread before. Not sure how strong Diosgenins progestogenic effects are, it feels more androgenic.
I have posted about syringic acid and the Chinese herb progestogen as well.
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@Mossy I really liked the effects it did worsen sleep though.
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@Mauritio @mossy i had a cup of lemon balm tea after lunch yesterday and it was very calming, similar to chamomile but not sleepy-calm. My guess is that lemon balm is better for day time stress, and chamomile better for after dinner nighty night time! 🫖
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Vitamin K2 Protects Against Glucocorticoid-Induced Osteoporosis by Activating the NRF2/FSP1 Pathway to Inhibit Osteoblast Ferroptosis
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Possible plan serotonin antagonists on 5HT3:
'Many constituents, such as gingerol, galanolactone, citronellol, geraniol, CBD, THC, eugenol, and vanillin, are reported to inhibit nausea and vomiting due to their 5-HT3R antagonism."
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Cysteine Sulfoxides(from onions) ehance progesterone production in vitro.
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@Mauritio Thank you. As someone who is hyper sensitive to most things, that's good to know.
"To desire action is to desire limitation" — G. K. Chesterton
"The true step of health and improvement is slow." — Novalis -
@dapose Interesting. Good to know. Thank you.
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@Mauritio shogaol is easily made from ginger powder you just put it in the oven with some acid dry it out for 60 minutes and it is usually a lot more beneficial than gingerol in 99% of cases
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@lobotomize thanks. i use ginger candy or chocolate and IIIRC the ginger in there should be heated is probably already converted to shoal.
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@Mossy another Peater said the same thing. So I don't seem to be the only one.
It's exceptional for colds/ flue, but somehow messes with sleep. Maybe GABA rebound effect ? -
List of (peaty) AMPK activators:
Biotin
Aspirin
Frankincense
Methylene blue
thyroid hromone,
fisetin
trehalose
lactoferrin
papain,
ecdysterone
phytol
vitamin D
apple polyphenols
Far infrared light -
Propolis extract (ethanolic)
Appears to have significant effects on healing of upper gastrointestinal tract mucosa (gastric & duodenal ulcers),
especially as treatment enhancement of antibiotics against H. pylori,
as well as for promoted healing thereafter (gastritis only slowly subsides over the course of at least 6 months up to a couple of years even after successful H. pylori eradication)Using human equivalent conversion from rat trials, generous daily propolis doses seem to be required: Ideally 3600mg. Certainly not below 1800mg.
Synergistic combinations with olive leaf extract (OLE) and/or L. rhamnosus and/or L. reuteri.
However, propolis monotherapy fails for H. pylori eradication. There's initial inhibition, but then the infection and bacterial evasion catches up.Propolis and Its Potential to Treat Gastrointestinal Disorders, 2018, review
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- Propolis in the Treatment of Oral Mucositis
** Propolis shown effective.
- Propolis in the Treatment of Oral Mucositis
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- Propolis in the Therapeutic Management of Ulcerative Colitis
** "the studies developed with kaempferol, luteolin, and naringenin stood out"
** yet "these studies do not translate to human application, remaining to be explored its efficacy and safety in clinical trials."
- Propolis in the Therapeutic Management of Ulcerative Colitis
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- Propolis and Its Potential to Treat Gastrointestinal Cancers
** Various effects in vitro
- Propolis and Its Potential to Treat Gastrointestinal Cancers
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- Antiulcer Activity of Propolis
** "propolis has been used in folk medicine to treat gastric ulcer"
** Dose-dependent protective effects (preventative), but also healing effects
** Effects of propolis mirrored in part by oral caffeic, ferulic, and cinnamic acids
** "100% of the tested extracts inhibited the H. pylori growth"
- Antiulcer Activity of Propolis
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"In vivo, the findings demonstrated that oral administrations of propolis and probiotics [L. rhamnosis, L. reuteri], either separately or in combination, led to significant increases in body weight and amelioration of histopathological changes in gastric tissue samples, particularly in terms of erosion depth, hemorrhagic inflammation, and apoptosis in the infected animals"
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Effects were dose-dependent and highest at 300mg/KG per day (HED = 48mg/KG, ie 3600mg@75KG). The yellow positive control received antibiotic triple therapy:
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"Propolis generally exhibits bacteriostatic properties against various bacterial genera; however, it may demonstrate bactericidal effects at elevated concentrations"
"Propolis contains caffeic acid phenethyl ester (CAPE), which inhibits the enzyme peptide deformylase, a critical factor for the survival of H. pylori." -
"The antibacterial activities of propolis are dependent on the concentration of biologically active compounds, including phenolic acid esters and flavonoids such as pinocembrin and galangin"
"During the study, a significant enhancement in the antibacterial activity was observed in the prepared propolis mixture (combination of all four propolis extracts). "
"In the gastric tissue samples of the animals treated with propolis and/or probiotics, reduced bacterial load comparable to the antibiotic-treated group animals was observed. "
"polyphenol compounds of propolis have significant enhancing effects on the eradication rate of H. pylori in rats with gastritis and peptic ulcers, suggesting that propolis supplementation may enhance the effectiveness of conventional H. pylori treatment"
- "These findings indicate that the use of Korean propolis, which has anti-inflammatory and anti-oxidative effects, can be promising for the prevention of H. pylori-induced gastric damage.
South African Propolis: Anti-Helicobacter pylori Activity, Chemistry, and Toxicity, 2025
Of 27 geographically distinct South African propolis sources tested, only 7 propolis compositions exhibited a MIC of >6.25 mg/mL against H. pylori. Many sources were as dose-effective as amoxicillin.
"Propolis from northern Spain was investigated against H. pylori with ethanolic and propylene glycol extracts which were found to have MIC values ranging between 6.00 and 14.00 mg/mL"- "The compounds pinocembrin, 3‐O‐acetylpinobanksin, and pinobanksin were found to be the most abundant."
"Antimicrobially active South African propolis was reported to be primarily comprised of pinocembrin, galangin, and chrysin"
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"Propolis demonstrates dual functionality by inhibiting the release of inflammatory mediators and suppressing H. pylori growth"
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"The combined use of propolis with other natural extracts demonstrates superior efficacy. Studies indicate that propolis complexes, when used in combination with olive leaf and licorice extracts, more effectively inhibit H. pylori-induced gastric mucosal ulcers, reduce bacterial colonization, and alleviate gastric mucosal inflammation"
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"A trial involving 18 infected participants showed that after seven consecutive days of oral administration of Brazilian green propolis extract (3 times daily, 20 drops per dose), 50% of participants experienced a decrease of over 20% in their urea breath test values, indicating an initial inhibitory effect; However, after a 40-day treatment cycle, 83% of participants failed to achieve complete eradication of H. pylori, suggesting that while propolis monotherapy has some activity, it is insufficient for effective eradication and may require optimization of the dosing regimen, such as increasing the dose or frequency, to achieve sufficient antimicrobial concentrations."
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Mulberry
I recently got introduced to mulberries by the great saint Hildegard von Bingen.
She had an astounding knowledge on plants and medicine. Mulberry is one of the things she recommended for improving liver health.
And indeed, there is a bunch of studies showing benefits on the liver, corroborating what she said already 800 years ago.
On top of that mulberries taste really good, I could see them pair well with yogurt and honey.
Liver:
It ameliorates NAFLD, Increasing ATP, endogenous antioxidants, michondrial complex I + II.
While lowering triglycerides, liver weight, FFAs and SCD1.
https://pubmed.ncbi.nlm.nih.gov/30643537/Mulberry extract lowers liver damage induced by the fungal toxin AflatoxinB1. It increases antioxidants, phase 2 liver detox enzymes and SCFAs in the gut.
https://pubmed.ncbi.nlm.nih.gov/41046554/It inubits liver inflamamtion in diabetes model. Lowers TLR4. Seems therapeutic for diabetes too.
https://pubmed.ncbi.nlm.nih.gov/35845591/Mulberry leaves extract ameliorates alcohol-induced liver damages through reduction of acetaldehyde toxicity and inhibition of apoptosis caused by oxidative stress signals
https://pubmed.ncbi.nlm.nih.gov/33390773/Mulberry leave polysaccharides increase the enzyme that converts cholesterol into bile acids and cholic acid in particular.
https://pubmed.ncbi.nlm.nih.gov/39490871/
Hormonal:
It strongly increases StAR in diabetic mice, to values even above the control group.
https://pubmed.ncbi.nlm.nih.gov/24644381/
Metabolism/Weight loss
It lowers weight on a HFD by over 5%. Decreases leaky gut and intestinal endotoxin.
https://pubmed.ncbi.nlm.nih.gov/41645603/Mulberry leave polysaccharides increase liver AMPK and bile acids.
https://pubmed.ncbi.nlm.nih.gov/33994909/Dare to think.
My X:
x.com/Metabolicmonstr -
@Mauritio mulberry trees are amazingly tough and birds spread their seeds extremely effectively in my city. White and black mulberry varieties grow wild along all parks and neglected areas. As a gardener I am always having to remove them and they put up the most incredible fight. You can cut them down completely over and over again and they just keep regrowing like “bring it on!” I’ve often joked that when humanity completely destroy this planet, mulberry trees along with a few others will be the life forms remaining to blanket and restore this earth. Long live the Mulberry tree!
I walk by them in the parks and gobble down the fruit in the summer! Love them!
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@dapose nice!
