Random, interesting studies

CrumblingCookie

@Mauritio said:

Dosage: HED was roughly around 1g/day of the essential oils in all cited studies.

1g of oregano/thyme/satureja EO every day is possible if dissolved evenly among a whole day's drinking water amount to not disintegrate one's mucosa but it's certainly not fun. About 10 drops per liter.

Mauritio

@Lejeboca i thought so too but then why are there studies using isolated Carvacrol having no effect ?

Lejeboca

@Mauritio, perhaps minimum inhibitory concentration (MIC) wasn't reached?
A study of the minimum inhibitory concentration and mode of action of oregano essential oil, thymol and carvacrol

Hard to hypothesize, in general, however. Do you have any specific study in mind you'd like us to look at?

Mauritio

@Lejeboca
Here is a Carvacrol only study, looking at Testosterone.
Fortunetly they used the same dosage (~around 1g HED) in this study.
And it showed no T increase for healthy animals but a strong increase in diabetic animals. So it had a restorative effect .

https://pubmed.ncbi.nlm.nih.gov/32153207/

But this still doesn't explain the 5X increase in the first study.
And the other rat study I posted also showed strong T increase in different dosages. So it doesn't seem to be a species related effect.

So with the satureja EO we see a T increase no matter if the animals are healthy and with Carvacrol only in unhealthy animals.

You can just buy an 80-90% Carvacrol orehano oil for 20-30 bucks so it should be easy to see if this works on humans.

LucH

@Mauritio said:

You can just buy an 80-90% Carvacrol orehano oil for 20-30 bucks so it should be easy to see if this works on humans.

Yes, could try but for sure you''l kill nearly the whole living stuff in your microbiome. Nearly all the phyla. The stronger will remain and occupy the place. And guess what would happen if you don't manage well afterwards... Nature abhores an empty place ...

useful info (decoding the study):
Reasons the Mouse Study is Irrelevant (or Misunderstood)
In healthy rodents, it actually lowers testosterone: Studies on healthy rats show that concentrated oregano essential oil causes testicular tissue injury and directly decreases serum testosterone levels. [1]
• It only fixes "broken" rats, it does not boost healthy ones: The rodent studies showing that carvacrol (the main compound in oregano) supports testosterone were done on rats that were explicitly poisoned with toxins, made diabetic, or subjected to extreme stress. In those cases, oregano acted as an antioxidant to protect damaged testicular cells. It does not increase baseline testosterone in healthy individuals. [1, 2, 3, 4]
• High doses actually lower testosterone: In studies on healthy rats, high oral doses of oregano essential oil actually caused reproductive toxicity, damaged Leydig cells, and significantly decreased serum testosterone levels and sperm counts. [1, 2]
• The delivery mechanism is totally different: Rodent studies often bypass the regular digestive process or use highly controlled extracts. When a human swallows a concentrated essential oil, it hits the stomach and upper intestines directly, wiping out the microbiota long before any theoretical benefit could ever reach the bloodstream.

Reproductive Toxicity Assessment of Origanum vulgare Essential Oil on Male Wistar Rats.
June 2015
Acta Scientiae Veterinariae 27(80):3-1