Silicon the dietary nutrient
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The mechanism of silicon involves promoting mitochondrial proliferation in macrophages through the upregulation of the Drp1-Mff pathway, which facilitates the transfer of functional mitochondria to endothelial and neuronal cells.
Our findings demonstrate that silicon enhances the ability of macrophages to transfer functional mitochondria to endothelial and neuronal cells, thereby improving their metabolic function and regenerative capacity.
Silicon is an essential micronutrient with potential regenerative effects mediated through mitochondrial regulation. It activates cellular defense mechanisms and, enhances resistance to ROS-induced toxicity.
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@A-Former-User said in Silicon the dietary nutrient:
anyone remember MrHappyOz of the nootropics world? He is pretty well known now and is a published author with work for treating post-viral illness and chronic fatigue. His protocol explains how silicon is essential for optimization of health after illness and via some sort of testing known as oligoscan has shown that Silicon in particular is low in the chronic fatigue / post viral illness type disease model.
Does anyone know which protocol he was refering to?
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I believe it was this protocol: https://bornfree.life/2024/protocol/
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what supplenment do you suggest solves this?
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@wester130 if this is a question for me, do you mean a supplement to cure post-viral syndrome?
The protocol I posted is not mine, I haven't even read it. But as mentioned in the OP of this topic, it says silicon deficiency could be involved in this disease.
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As @Mossy points out above, Ray Peat saw silicon/e or silica in supplements as powdered glass. Also Pretty sure i heard or read him saying that silicon/e or silica that occurs naturally in foods is something completely different to that which is found in supplements. My own takeaway is to avoid any supplement containing it.
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@otto said in Silicon the dietary nutrient:
Here is the brand that I chose. It claims to be a 1-year supply.
According to LLR, silicium molecule has to be small enough to be effective.
Dr. Willems has tested several sold silicium a long time ago. They are not all equal, to say the least.
Usful info:
When I type « silicium » on my forum I get 4 posts in the section « Traitements naturels et complémentaires »:- Silicium organique ou minéral ?
https://mirzoune-ciboulette.forumactif.org/t864-silicium-organique-ou-mineral?highlight=silicium - Silicium organique et arthrose. Dr JM Dupuis
https://mirzoune-ciboulette.forumactif.org/t866-silicium-organique-et-arthrose-jm-dupuis?highlight=silicium - Test silicium. Dr Willems
https://mirzoune-ciboulette.forumactif.org/t865-test-silicium-dr-willems?highlight=silicium
Extraits en Français (Translator needed) :
Extrait 1 :
Le corps humain contient de 6 à 10 grammes de silice selon l'âge, et 1 mg par 100 ml de sang. Le silicium est en concentration supérieure (7g) à celles du fer (Fe) ou du cuivre (Cu) chez l’homme ; il potentialise l'action du zinc (Zn) et du cuivre (Cu) et permet la fixation du calcium (Ca).
La quantité de silicium diminue de façon irréversible, chez l'homme comme chez l'animal.
On le trouve essentiellement dans le tissu conjonctif, dans la peau, les cheveux, les ongles et les dents, dans les os et le sang.
Un traitement à base de silicium organique peut d'ailleurs faire régresser ces lésions athéromateuses (travaux de LOEPER, Académie de Médecine). Il restaure également la synthèse de l'élastine, tout en diminuant la calcification et la rigidité des artères vieillissantes. Il est frappant de constater que ces tissus (peau, artères, thymus) sont ceux dont le vieillissement est le plus constant et le plus marquant (ainsi rides, amincissement, perte d'élasticité et d'hydratation pour la peau)."
http://www.esculape.com/bricabrac/silicium.htm
Extrait 2 : Organique ou minéral ?-
Le silicium organique : Taux d’absorption élevé (70%)
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Le silicium minéral : problème de biodisponibilité (3%)
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Le silicium végétal : champignons, graminées, agrumes, olives, argile verte, prêle, gélatine, eau, etc.
NB : La biodisponibilité sera faible, comparée à une plante, sauf si …
Extrait 3 : Conditions liées à l’assimilation -
Le pH du silicium ainsi que sa charge ionique. Le titrage du silicium (0,2 % est l’idéal selon LLR ; 0.4 % est un maximum pour l’assimilation => biodisponibilité).
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Besoin d'une protéine qui lui sert de transporteur, pour passer la barrière digestive, il est limité à un seuil de saturation dans les applications thérapeutiques. Voilà pourquoi il est conseillé de l’ingérer 15’ avant le début d’un repas.
Extrait 4
Le silicium organique se différencie du minéral par la présence d’un (ou plusieurs) atome(s) de carbone associé(s) à de l’hydrogène. Sous cette forme, c’est un des éléments essentiels de la matière vivante (plantes, animaux et humains).
Liens intéressants : -
Silicium organique : Présentation. Connaissez-vous le G5 ?
Applications, revendications du silicium organique en thérapeutique.
Source: Dr Janet, gastro-entérologue et cancérologue.
http://www.nature-et-forme.info/article-739693.html (blog temporairement indisponible)
https://sante-vivante.fr/wp-content/uploads/2018/07/SV-SILICIUM-3.pdf -
7 siliciums au banc d’essai
Test du Dr WILLEMS
Le silicium : produit mythique de la médecine naturelle
Samedi 17 février 2007 • Pratiques de santé. Le Journal de la Médecine naturelle. N° 64 Hors-série n° 1. Dr Jean-Pierre WILLEM. Epuisé.
https://mirzoune-ciboulette.forumactif.org/t865-test-silicium-dr-willems#8167
Résumé du test:
Si l’on cumule l’ensemble des résultats obtenus, le classement final est le suivant :
1 - G5
2 - Dynasil +
3 - Ortie-Silice
4 - Eau de silice
4 - Siliplex
6 - Silicea Universel
7 - Vita Sil.
Seul 3 1ers sont recommandables.
NDLR: Il existe peut-être d'autres produits apparus ensuite sur le marché, non testés ...
Translation : Only the first three are recommended.
Editor's note: There may be other products that appeared on the market later, but haven't been tested...
I use G5.
- Silicium organique ou minéral ?
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Apparently the Slovenian mineral water Donat not only has a whopping 1,030 mg Magnesium per Liter (as far as I know the most magnesium-rich water in the world by a big margin), plus 350 mg Calcium and 7,700 mg bicarbonat, but also 86 mg silica/silicon per Liter.
https://fine-liquids.com/en-us/products/donat-mg
Unfortunately very expensive to import to other countries. In Slovenia it's quite affordable. But if anyone wants to emigrate there, it's very beautiful.
Gerolsteiner has 40 mg/L according to the same source. Also a good amount.
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@Luke Cost 2€ for 0,5l for me here
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BioSil and Silica G5 are not the same as silicon dioxide (the silica filler we talked about earlier).
They are specialized supplements designed to deliver bioavailable silicon for health benefits (like collagen support, hair, skin, nails, and bones), while silicon dioxide (SiO₂) is the inert, poorly absorbed form used as an anti-caking filler.
Silicon dioxide (filler): This is the same compound as sand/quartz.
BioSil and suppements: This is not silicon dioxide. The manufacturer starts with silicon from sand (SiO₂), but chemically converts it into orthosilicic acid (the natural, absorbable form of silicon found in mineral water and some foods).
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Why G5 or the same sized molecule works at low concentration
G5 is not a dissolved mineral. It travels as a tiny particle — small enough to slip into a cell without needing a receptor or a gate. Once inside, its silicon surface is chemically reactive in a specific way that stimulates collagen production.
Think of it like a very small key rather than a large dose of a nutrient. The key doesn't need to be present in large quantities. It just needs the right shape to open the right door.
The "right shape" here is the unusual geometry of the carbon-silicon bond — which orients three reactive hydroxyl groups in a way that mineral silicon, dissolved in water as an ion, simply cannot replicate.
That's it. Small particle, right shape, gets inside, does a specific job.Silicon is not just a structural material. At the cellular level it acts as a biological catalyst for hydroxylation reactions.
Silicon also participates in:
Glycosaminoglycan synthesis — the gel-like molecules that hydrate cartilage and interstitial tissue
Elastin formation — the protein that gives arteries and skin their elastic recoil
Mitochondrial membrane stability — silicon-hydroxyl interactions help maintain membrane fluidity under oxidative stress
NB: Need a further development: Mitochondrial energy as a key mechanism to optimize recovery.
Mitochondria — the actual bottleneck of recovery
Every repair process that could be discussed — collagen synthesis, glycosaminoglycan production, elastin formation — is energetically expensive. It runs on ATP. And ATP is produced almost exclusively in mitochondria.
The mitochondrial inner membrane is where this production happens — specifically at the electron transport chain, a series of protein complexes embedded in that membrane. Their efficiency depends entirely on membrane fluidity and integrity. QED (CFFD, in French: What had to be demonstrated / proved).
Excerpt
Silicon as Versatile Player in Plant and Human Biology
Source: doi: 10.3389/fpls.2015.00994
Si bioavailability in human diet, e.g., strengthens bones and improves immune response, as well as neuronal and connective tissue health. Despite this empiric knowledge, the essentiality of Si still remains enigmatic.
