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Iodine as a game changer

The Junkyard
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  • M
    Mossy @LucH
    last edited by Mar 24, 2025, 6:15 AM

    @LucH

    I really appreciate the in-depth information. I will add this to my notes. Thank you.

    I do have Selenomethionine, but it may be outdated by now. I've had it for at least 5 years.

    "To desire action is to desire limitation" — G. K. Chesterton
    "The true step of health and improvement is slow." — Novalis

    1 Reply Last reply Reply Quote 0
    • M
      Mossy @yerrag
      last edited by Mossy Mar 24, 2025, 6:36 AM Mar 24, 2025, 6:33 AM

      @yerrag
      That is an interesting take, and one that is consistent with other success stories I've heard — where one's diet brought them back from a point of deficiency, allowing for success that otherwise would not be possible. As you say, a lot does come into play, but at the very least, high quality food — that which normally would need to come from outside the corporate food monopoly — should be objective #1. I have been positioning myself for that, over the last several years, but I'm not 100% free yet, from the corporate food manufacturing system. Though, I have been able to eat as whole food as possible, though just not from my own garden yet, or from local farms. Little by little I hope to get there.

      I hear you on farmed sea food. I do look for wild caught, but due to budget constraints I need to wait for it to go on sale. Sea food is probably my least eaten food, simply due to price. Though, i do like it.

      Alamang sound interesting. I'll have to look those up.

      @LucH @yerrag
      After a quick search I see my original understanding of iodide and iodine was lacking, to say the least. I thought they were distinct from each other. But this quote helps to clarify: "... iodide is the ionic form of iodine."

      "To desire action is to desire limitation" — G. K. Chesterton
      "The true step of health and improvement is slow." — Novalis

      1 Reply Last reply Reply Quote 0
      • V
        visalibero @yerrag
        last edited by Mar 24, 2025, 10:46 AM

        @yerrag I'm not using anything right now. I did a 10-day cycle of 300 mg doxycycline and it doesn't seem to be much better, in fact.

        The SSKI I bought is hurting my teeth and it had turned orange... even though it was initially transparent. Maybe it's a defective product! Tomorrow I should start with diluted sodium hypochlorite that a dentist friend got me. To rinse. I think it's essentially bleach. I always use erythritol and xylitol after meals. It helps a little but I feel like the disease hasn't stopped.

        It seems impossible to get chlorine dioxide here in Italy. It's much more difficult here. Even SSKI requires a doctor's prescription to get it. It took me a month to find a doctor who would prescribe me doxycycline.

        And at customs they block the orders and send the goods back.

        Y 1 Reply Last reply Mar 24, 2025, 11:30 AM Reply Quote 0
        • Y
          yerrag @visalibero
          last edited by Mar 24, 2025, 11:30 AM

          @visalibero said in Iodine as a game changer:

          @yerrag I'm not using anything right now. I did a 10-day cycle of 300 mg doxycycline and it doesn't seem to be much better, in fact.

          The SSKI I bought is hurting my teeth and it had turned orange... even though it was initially transparent. Maybe it's a defective product! Tomorrow I should start with diluted sodium hypochlorite that a dentist friend got me. To rinse. I think it's essentially bleach. I always use erythritol and xylitol after meals. It helps a little but I feel like the disease hasn't stopped.

          It seems impossible to get chlorine dioxide here in Italy. It's much more difficult here. Even SSKI requires a doctor's prescription to get it. It took me a month to find a doctor who would prescribe me doxycycline.

          And at customs they block the orders and send the goods back.

          It's hard to imagine how restrictive Italian health restrictions are. It must reflect the state of the EU now.

          It seems that you need to go away from the EU as s prerequisite to getting meaningful healing done.¹

          Temporal thinking is the faculty that’s
          engaged by an enriched environment, but it’s
          wrong to call it “thinking,” because it’s simply
          the way organisms exist... - Ray Peat Nov 2017 Newsletter

          V L 2 Replies Last reply Mar 24, 2025, 12:57 PM Reply Quote 0
          • V
            visalibero @yerrag
            last edited by Mar 24, 2025, 12:57 PM

            @yerrag up until 6 months ago it wasn't like this. now it seems impossible to get certain categories of products delivered.

            Y 1 Reply Last reply Mar 25, 2025, 10:11 AM Reply Quote 0
            • Y
              yerrag @visalibero
              last edited by Mar 25, 2025, 10:11 AM

              @visalibero

              since you're not that far away from Germany or Switzerland, being in Milan, would a trip there and back allow you to get some substances that are sold there?

              Temporal thinking is the faculty that’s
              engaged by an enriched environment, but it’s
              wrong to call it “thinking,” because it’s simply
              the way organisms exist... - Ray Peat Nov 2017 Newsletter

              1 Reply Last reply Reply Quote 0
              • L
                LucH @yerrag
                last edited by LucH Mar 25, 2025, 10:23 AM Mar 25, 2025, 10:22 AM

                @yerrag said in Iodine as a game changer:

                at customs they block the orders and send the goods back.

                All hormones are blocked from outside Europe.
                The control has been heavier since 2025 January. Before, TVA (added value fee / tax) was not due under 150 €, all costs included (carrier). No order above 150 € or you get problems.
                Now if the TVA has not been paid by the sender, it takes much more time and is often more complicated (extra fee must bee paid before delivering). A detailed bordereau must be joined.
                If you order unapproved molecules (hormones), the packaged will be destroyed or send back to the seller, but on the second time you'll be "punished" by the law.

                V 1 Reply Last reply Mar 25, 2025, 5:38 PM Reply Quote 0
                • V
                  visalibero @LucH
                  last edited by Mar 25, 2025, 5:38 PM

                  @LucH
                  I would like to get sski or chlorine dioxide.

                  not hormones!

                  L 1 Reply Last reply Mar 25, 2025, 6:10 PM Reply Quote 1
                  • L
                    LucH @visalibero
                    last edited by LucH Mar 25, 2025, 6:12 PM Mar 25, 2025, 6:10 PM

                    @visalibero said in Iodine as a game changer:

                    I would like to get sski or chlorine dioxide.

                    Sski Potassium Iodide Liquid 250 mcg
                    https://www.amazon.com/sski-potassium-iodide-liquid/s?k=sski+potassium+iodide+liquid
                    Bottle 30 ml, 250 mcg/1 drop. As potassium iodide oral solution, USP. Very expensive.

                    You’ve got the same product with Life-flo on iherb.com, 59 ml (2 oz.) for +/ 7.5 €.
                    150 mcg / 1 drop.
                    NB: Do not leave open. 3 months validity (evaporation when liquid)

                    When you want more; I’d take optimox iodoral 12.5 mg (12 500 mcg)
                    Choice between 6.25 or 12.5 or 50 mg, 90 or 120 scored tablets.
                    https://ci.iherb.com/search?sug=iodoral 12%2C5&kw=iodoral 12%2C5&rank=2&rawkw=iodorale 12.5&refererLocation=suggestion

                    Note: If you want to use dioxide chlorine for mouth wash, I’d prefer to do it / try it first with green tea. 10-15’ 1 tsp infused. Only with green tea. 3-4 times/day for 3-4 minutes. Wait 4-6 days before results.
                    Combine with iodine potassium, but progressively if ingested, to avoid Wolff-Chaikoff effect.

                    Before paying, verify the option Added fee (European Tax) has been taken into account.

                    1 Reply Last reply Reply Quote 0
                    • T
                      thyroidchor27 @NNight
                      last edited by Mar 29, 2025, 1:52 PM

                      @NNight Iodine works well in the winter for boosting thermogenesis but I think in the summer its not really needed.

                      L 1 Reply Last reply Mar 29, 2025, 4:22 PM Reply Quote 0
                      • L
                        LucH @thyroidchor27
                        last edited by LucH Mar 29, 2025, 4:41 PM Mar 29, 2025, 4:22 PM

                        @thyroidchor27 said in Iodine as a game changer:

                        Iodine works well in the winter for boosting thermogenesis but I think in the summer its not really needed.

                        what about the other parameters?
                        If you feel / perceive cold hands or feet only in the winter, there are probably other symptoms of low metabolism you're accustomed and therefore think it's normal, or at least you manage with ... Until when !?
                        And it's not because you don't perceive it yet (under the radar), there aren't any low-grade problems ...

                        https://www.news-medical.net/news/20240321/Exploring-the-role-of-iodine-in-obesity-diabetes-and-other-metabolic-conditions.aspx
                        => The correlation between iodine and metabolism: a review.
                        Excerpt
                        Mechanisms underlying the metabolic effects of iodine
                        Iodine exerts antioxidative, antimicrobial, immunomodulatory, and molecular regulatory effects. Iodine alters the proportion of pathogenic and beneficial bacteria to restore the gut microbiome and reduce insulin resistance, obesity, and metabolic syndrome parameters.
                        Iodine also reduces inflammation by lowering oxidative and endoplasmic reticulum stress caused by free radicals such as reactive oxygen species (ROS).
                        Iodine acts on the Kelch-like ECH-associated protein 1-NF-E2-related factor 2 (KEAP1-NRF2) pathway to enhance the activities of antioxidant enzymes such as superoxide dismutase (SOD), catalase (Cat), and glutathione peroxidase (GSH-Px).
                        In addition, iodine alters inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX2) levels, regulating mitogen-activated protein kinase (MAPK) and nuclear factor kappa B (NF-κB) pathways to reduce chronic inflammation and improve metabolic health.
                        The mineral acts on type 2 deiodinase (D2) receptors that convert T4 to biologically active T3 to improve weight management and adaptive thermogenesis.
                        Iodine also interacts with peroxisome proliferator-activated receptor-γ (PPARγ) receptors to enhance adipocyte differentiation, fatty acid uptake, and glucose metabolism ...
                        Source: The correlation between iodine and metabolism: a review.
                        2024 | https://doi.org/10.3389/fnut.2024.1346452

                        1 Reply Last reply Reply Quote 1
                        • L LucH referenced this topic 26 days ago
                        • L
                          LucH
                          last edited by about 14 hours ago

                          Deiodinase enzymes and thyroid activity
                          Situation:
                          A person is hypotensive and is taking a synthetic T3 and T4 supplement. The dose is taken gradually and with modulated doses. Metabolism improves and fueling is better, but this only lasts for a short time. Why? Symptoms return:
                          "Feeling cold immediately after taking Cynoplus. What's going on?"

                          Impact of Iodine and Selenium Deficiency on Deiodinase Enzymes
                          Deiodinase enzymes are selenoproteins, meaning they require selenium to function properly. If the body is deficient in selenium, these enzymes may not be sufficiently active, which can disrupt the proper conversion of thyroid hormones. Furthermore, iodine is essential for the synthesis of thyroxine (T4), and an iodine deficiency can lead to insufficient T4 production, worsening hypothyroidism.
                          In such a situation, supplementing with T3 and T4 may temporarily improve symptoms, but if the body lacks the nutrients needed to properly activate or degrade these hormones (via DIO1, DIO2, and DIO3), the beneficial effects will be limited over time. In other words, taking T3 and T4 may only mask a deeper problem related to disturbed hormonal metabolism, rather than resolving the underlying cause.

                          Role of DIO enzymes
                          Three enzymes catalyzing deiodination have been identified, called type 1 (D1), type 2 (D2) and type 3 (D3) iodothyronine deiodinases. D1 and D2 have outer ring deiodinase activity, converting the prohormone T4 to its bioactive form T3 and degrading rT3 to 3,3’-T2. D3 has inner ring deiodinase activity and degrades T4 to rT3 and T3 to 3,3’-T2. (…)
                          Note (you can jump to next paragraph): 3,3’-T2 or 3,3'-Diiodo-L-thyronine is a metabolite of thyroid hormone that is also known as T2 or 3,3'-T2. It is derived enzymatically from triiodothyronine isoforms T3 and reverse T3. T2 plays many of the same roles as T3 but acts on different receptors. . Since there are no commercially available assays for T2, and T2 does not suppress TSH, its absence can contribute to hypothyroidism without being measurable.
                          https://thyroidspecificformulations.com/wp-content/uploads/2023/04/TSF-Factsheet-T2-T3-Converter.pdf

                          Combustion Engine Analogy
                          Let's imagine our metabolism as a car engine. If this engine runs on pistons without oil, this will lead to excessive friction, overheating, and eventually malfunction, even if the engine is still running. In this case, the oil represents the essential micronutrients (selenium, iodine, zinc, etc.) needed to properly activate and regulate the function of the enzymes that modify the combustion (or metabolism) of thyroid hormones.
                          Similarly, even if the car engine (our metabolism) continues to receive fuel (the T3 and T4 supplements), without the proper "lubricants" (the micronutrients), the engine will eventually run into problems. The intake of these micronutrients is essential to optimize the function of deiodinase enzymes and maintain metabolic hormonal balance.

                          To be continued on this link (in French, but with study references in English):
                          Micronutriments utiles au fonctionnement de la thyroïde (Useful nutrients for thyroid fuction)
                          https://mirzoune-ciboulette.forumactif.org/t2107-la-supplementation-en-hormones-thyroidiennes-masque-la-carence-en-iode#30191

                          • Impact of iodine and selenium insufficiency on deiodinase enzymes in order to maintain a balanced hormonal metabolism.
                          • Caution regarding iodine supplementation (to avoid the Wolff-Chaikoff effect).
                          • The key to iodine supplementation is gradualness, allowing the body to adapt and avoid unwanted side effects.
                          • Thyroid hormone supplementation (T3 & T4) masks iodine deficiency.
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