Cyanidin-3-O-glucoside (C3G), the next polyphenolic StAR ?

Lejeboca

In the US, American elderberry (Sambucus canadensis) is more prevalent than the European (black) elderberry (Sambucus nigra).

S. canadensis "individuals ranged nearly threefold from 1308 to 4004 µg [of cyanidin 3-glucoside equivalents] (cy3-GE)/g on a fresh weight basis" per this paper that assesses 14 different varieties in the US.
Total phenolic, anthocyanin contents and antioxidant capacity of selected elderberry (Sambucus canadensis L.) accessions

Comparing the two species of elderberry in a metanalysis, the following paper concludes this about their composition:
"The most abundant type of anthocyanidin in the European and the American elderberries is cyanidin. In S. nigra, the anthocyanins are not acylated, while in S. canadensis the major individual anthocyanins are acylated with E-p-coumaroyl functionality at C-3. Acylation was reported to stabilize anthocyanins against heat and light. However, glycosidation was observed to improve the stability of anthocyanins against light, but not against heat. Despite the structural variation of the anthocyanins—-represented by a number of hydroxyl groups and the substitution of hydroxyl groups with methoxyl groups, as well as the type and number of sugar residues attached to the flavylium cation via glycosidic linkages—the literature reveals that the anthocyanins of different cultivars of elderberry share several pharmacological effects."
Elderberry Extracts: Characterization of the Polyphenolic Chemical Composition, Quality Consistency, Safety, Adulteration, and Attenuation of Oxidative Stress- and Inflammation-Induced Health Disorders

Mauritio

@Kvothe Interesting , never heard of those. But Ill get some elderberry juice and try it out.

The dose might be important. I haven't looked into the HED of all those studies and approximately how much elderberry juice that translates to , yet.

Mauritio

@Lejeboca Thanks!

@Mauritio Whats your view on black bean extract which also contains C3G, might it be a more economical form to take....Dunno

Mauritio

@Not_James_Bond
Depends on the cost.

Elederberry juice is good. Dried elderberries are pretty economic since they contain a lot more C3G per gram.

Mauritio

I posted a lot more studies on C3G in this thread on the forum that had to do with Ray Peat.
just too lazy to post them all here.

https://raypeatforum.com/community/threads/cyanidin-3-o-glucoside-c3g-the-next-polyphenolic-star.52555/

brightside

Thanks for putting all of this together, @Mauritio .

I kept an eye on the thread at RPF and was mildly interested, but when I saw that it induces uncoupling AND it increases bile output, I just had to try it.

Like someone mentioned on the other thread, using this with Pu-erh is probably going to be highly effective. The increased use of acetylcoa into cholesterol and increased bile acid synthesis is going to be super effective for reducing reductive stress, not to mention the uncoupling effect and enhanced sirt6 activity.

Then you have the increased star activity too. Thus is just a really cool compound.

So far I’m on day two, and I can say that it does really work for stimulating digestion. I have an issue with sluggish peristalsis that weakly responds to pretty much everything. Huperzine A seems moderately effective, but higher than 200mcg I get cramps. Magnesium sucks, and everything else is kind of useless.

I’ve taken two doses so far, and both times it crashed me pretty hard, mainly because my digestive system started working too abruptly. I’m thunking that if I keep going,

Mauritio

Thanks for mentioning. I forgot about taking it. It made me kind of wired but tired after a while ,but I did enjoy it. And might try it again.

brightside

@Mauritio said in Cyanidin-3-O-glucoside (C3G), the next polyphenolic StAR ?:

Thanks for mentioning. I forgot about taking it. It made me kind of wired but tired after a while ,but I did enjoy it. And might try it again.

Oops. I actually wrote this like a month ago, but when accessing the forum yesterday from my phone this posted for whatever reason and I didn't notice.

I've also stopped using it. It was just way too damn stimulating on the digestive system. I did like the pro-dopamine effects though, very noticeable and powerful, most definitely.

cs3000

@Mauritio said in Cyanidin-3-O-glucoside (C3G), the next polyphenolic StAR ?:

Thanks for mentioning. I forgot about taking it. It made me kind of wired but tired after a while ,but I did enjoy it. And might try it again.

Looked promising, but it blocks DHT / androgen receptor unfortunately , https://www.sciencedirect.com/science/article/abs/pii/S0014299923007513 https://ars.els-cdn.com/content/image/1-s2.0-S0014299923007513-gr5.jpg
,
(a lot of these have anti androgen / dht effects alongside the estrogen lowering , maybe if something is significantly more potent on estrogen effects would outweigh idk, some are neutral but i think the only one ive seen with opposite effect on dht is naringenin (not naringin)

,

maybe the increased star is trying to balance the lowered AR activation (and increase androgen receptors as theyre being activated less? id like to see if they measured activation in that rat study cant find it , they used low dose not sure what dose was, maybe theres an optimal dose to not get the anti androgen effect but idk if the star effect would happen then)

"DHT increased AR mRNA and AR protein expression, but their expressions were reduced to control levels with C3A treatment "
(works same for c3a or c3g)

https://onlinelibrary.wiley.com/doi/full/10.1002/fft2.139 in vitro C3G here inhibits mitochondrial respiration/oxygen consumption at 150nM , in humans in blood hits ~150nm from 500mg so looks too high a dose
https://bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.12676

But C3A / C3G does look effective for hair regrowth w short term use,

(interesting mention of lower mitochondria calcium mechanism for hair loss reversal also
https://www.researchgate.net/publication/359068150_Cyanidin_3-O-arabinoside_suppresses_DHT-induced_dermal_papilla_cell_senescence_by_modulating_p38-dependent_ER-mitochondria_contacts

worked for hair regrowth topically with oil:ethanol 7:3 ratio at 500uM every 2 days, maybe 100mg a day topically , & https://ars.els-cdn.com/content/image/1-s2.0-S0014299923007513-gr2.jpg