Dandruff or scalp irritation? Try BLOO.
This got me thinking that, since our endogenous CORT is "naturally" elevated in the morning, if we have an LPS-prone breakfast, then any existing inflammation will spike.
So
@yerrag said in Thymus health:
was it to calm the cytokine storm as a way to dampen Inflammation? I just know cortisone is used as an anti-inflammatory but don't know the mechanism.
Below is a study that considers the dual pro- and anti-inflammatory effects of cortisol under stress with respect to the time of introduction of immune challenge (LPS), It also notes the mechanism of upregulating TLRs, which recognize pathogen molecular patterns, in the brain and liver.
Abstract
Acute and chronic stress has been found to sensitize or prime the neuroinflammatory response to both peripheral and central immunologic challenges. Several studies suggest that stress-induced sensitization of neuroinflammatory processes may be mediated by the glucocorticoid (GC) response to stress. GCs, under some conditions, exhibit pro-inflammatory properties, however whether GCs are sufficient to prime neuroinflammatory responses has not been systematically investigated. In the present investigation, we tested whether acute administration of exogenous GCs would be sufficient to reproduce the stress-induced sensitization of neuroinflammatory responses under a number of different timing relationships between GC administration and immune challenge (lipopolysaccharide; LPS). We demonstrate here that GCs potentiate both the peripheral (liver) and central (hippocampus) pro-inflammatory response (e.g. TNFα, IL-1β, IL-6) to a peripheral immune challenge (LPS) if GCs are administered prior (2 and 24 h) to challenge. Prior exposure (24 h) to GCs also potentiated the pro-inflammatory response of hippocampal microglia to LPS ex vivo. In contrast, when GCs are administered after (1 h) a peripheral immune challenge, GCs suppress the pro-inflammatory response to LPS in both liver and hippocampus. GCs also up-regulated microglial activation markers including Toll-like Receptor 2. The present data suggest that the temporal relationship between GC treatment and immune challenge may be an important factor determining whether GCs exhibit pro- or anti-inflammatory properties.
Although the study considered a pretty high dose of cortisol (CORT), smaller (and chronic) doses would have a similar effect, in its nature, *the authors fixed the measurements at 4h of LPS introduction.
A dose of CORT was chosen that had previously been determined to mimic the plasma CORT profile produced by an acute stressor (a session of 80–100 inescapable tailshocks) (Fleshner et al., 1995). We had found that this acute stressor potentiates the neural and peripheral inflammatory responses to LPS administered 1–4 days later (Johnson et al., 2002).
@b1 said in Boron supplements:
I cant find any borax supplements unless you mean the cleaning / slime making stuff
Indeed, to second @noseleather borax 'for cleaning' is good stuff. (modulo 'slime making' probably .lol)
Anecdotally, I add Borax powder to wash my linens (and light-colored clothes). This is my only 'supplement' with Borax. Idealabs hair tests showed a good load of boron. This was my only change in boron consumption. (I used to and I do eat quite a bit of raisins too.)
05/2024 -- Hair 05/2023 -- Hair
@Mauritio
Travis also spoke about boron as a 'natural fluoride's antidote' :
"This [catechol‐O‐methyltransferase] enzyme can be safely inhibited with epicatechin gallate, found in high concentrations in green tea. However, green tea also has fluoride; this fact would make me add fluoride's natural antidote—boron—to the tea."
@Mauritio said in Just 1 minute of red light is effective:
Just one minute in the morning was enough to improve eye health in a study . It only worked in the morning as far as I remember. There seems to be something about red light in the morning being very healthy
Some time ago, I posted about it on RPF here.
Below is that post screenshot as I don't know whether the link is generally usable.
@LetTheRedeemed , Ray recommends gelatin to be about 1/3 of the total amount of protein since gelatin is missing essential amino acids.
For me, the ratio has to be even lower, of about 1/4, not produce negative effects such as brittle nails and hair.
@DavidPS , the main takeaway from the paper in the OP is that sometimes you absolutely want to suppress NO (and iNOS) and sometimes you might not want to do so. The former is broadly true for autoimmune conditions and the latter is for true infections, esp. those with which the body has to deal with whatever means it can.
Thanks for the article Inducible Nitric Oxide Synthase: Regulation, Structure, and Inhibition (2020) !
It will take me some time to digest its 45 pages 
. The abstract, however, already points to the dichotomy, "both the dual modalities of iNOS and NO in disease states (i.e., protective vs. harmful effects)" indeed.
@happyhanneke said in I need x-rays:
I've been consuming gelatin and a carrot salad for a long time now. I'm also taking aspirin and cynomel.
To start with, I'd stop these substances, unless they are vitally needed for you.
Firstly, to start with a clean slate, and maybe add those gradually as needed.
Secondly, depending on the ratios of gelatin to other proteins, the amount of carrot salad, aspirin and cynomel doses, these substances may not be benign (!).
@happyhanneke , I agree with @LetTheRedeemed that this could be dealt with without x-rays.
I'd try to rule out hypotheses one by one: Do something for arthritis for a week, if helps continue (adjust), If not move on to another hypothesis for another week. This algorithm, of course, assumes that you research precise remedies for specific hypotheses and not throw a kitchen sink on each (because with a kitchen-sink approach, it will be hard to differentiate what works.)
@DavidPS , thanks!
The links to the book that I found via the rpf search
( http://krishikosh.egranth.ac.in/bitstream/1/2027529/1/HS1519.pdf )
didn't work for me [Site not accessible] .
But I managed to get a copy via scihub. Use 0046410236 in the search field. [This is book's ISBN.]
The annas-archive site worked for the books too,
Also, for laughs, check out Let's Eat Right to Keep Fit
Reviewed by: Robert E Shank >
