the last piece of the peaty puzzle ? simplified with ai
-
@user1 deplete what?
-
@lobotomize what AI did you use? I don't trust anything other than the longest thinking options like grok 4.20 expert or Gemini 3.1 pro
-
I actually found it quite interesting and thought it would be important to expand on the theory to include more recent developments; I remember him mentioning that this theory was proposed 10 years ago or so; I don't know how up-to-date it is.
For example, would the fact that melatonin is a VDR agonist have an impact?
-
@lobotomize said in the last piece of the peaty puzzle ? simplified with ai:
the last piece of the peaty puzzle?
As you're asking, I don't think it's most of that.
CIRCADIAN RHYTHMS
I think this and an infradian one are probably involved though.
It's a good day on here.
-
@engineer claude 4.6 1mil context gemini 3.1 got nerfed instantly post benchmarking and grok 4.20 is more hype tthan good
-
@lobotomize said in the last piece of the peaty puzzle ? simplified with ai:
@user1 deplete what?
Everything or a lot of things
-
@user1 thanks for the quick fact
-
-
@lobotomize There are countless studies showing the benefits of vitamin D3, IMO, you are focussing way to much on genetically modified knock-out animal models and in vitro studies, both of which do not replicate normal, in vivo circumstances. BTW, vitamin d3 can DECREASE conversion to 1-25 hydroxyvitamin D and realistically, the ratio between the two matters probably as well.
https://dannyroddy.substack.com/p/vitamin-d-bioenergetic-wunderkind
-
I think the mTOR-always-on is a general problem with any low-stress targeted approach, not limited to milk. Some stress is required for normal metabolic functioning. Fasting during the night and exercising is a good way of "micro dosing" stress in a way that is actually beneficial.
The rest I wouldn't read too much into. AIs are dumb as fuck.
-
This picture of VDR knockout mice being "lean" and "obesity resistant" is taking some of the trees for the forest and claiming it's the whole forest. If you are insulin resistant, generally force-feeding a lot of carbohydrate substrate without any other measures is probably not a good idea. Are carbohydrates bad? No.
Vitamin D has been skewed, I am sure intentionally, as a general calcified public is also "paradoxically" calcium deficient, or more aptly on a very low calcium:phosphate ratio, focusing on inflammatory, active D (1,25) paints the perfect, evil picture of vitamin D overall and is frankly wrong.
Hydroxylases tightly regulate local conversions to 1,25 from 25. What interrupts this regulation? Calcium deficiency, estrogens, PUFA. In other words pre-inflammatory state.
Knockout mice, barring all other factors of health - which is usually the game here in these worthless studies - will not experience this inflammatory, dysregulated system. And looking only at this narrowly through a lens, you derive your conclusion you are looking for: manipulating the meaning and function of things. In reality, in the real world, the better method in avoiding these inflammatory responses is, you guessed it, sufficient calcium, low PUFA, in turn keeping estrogen in check, and being careful of other inflammatory things. Much like the knockout mice scenario, removing some apparatus to prove something is bad, when that something itself is hijacked and fed into a detrimental cycle is a sleight of hand, not proof. Vitamin D is not the problem, and VDR knockout doesn't prove it is, only in that if 25 is converted via inflammation.
Lipopolysaccharide derived MKP-1, inhibition by inactive D already shows vitamin D is an anti-inflammatory, but not 1,25. And 1,25 is one of the resident experts of inflammation, when conditions of health are not met. Get tho9se conditions met and D does what it does that is good for us. By the way, progesterone and methylene blue also help
Also, "constant milk intake" is an absurd, hyperbolic suggestion. I am certain nobody here has an IV of milk coursing through their veins 24-7. You have some milk throughout the day, then we all fast whether we know or not: it's called sleep.
