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    Prolactin is an innocent bystander and may even be beneficial

    Scheduled Pinned Locked Moved Literature Review
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    • alfredoolivasA Offline
      alfredoolivas
      last edited by alfredoolivas

      Human studies
      "a 2-3 fold increase of circulating PRL levels maintained for 1.5-3 h exerted no apparent effects on the secretion of endogenous LH, FSH and TSH."
      https://pubmed.ncbi.nlm.nih.gov/8258642/

      "Prolactin does not acutely influence renal electrolyte excretion and probably does not influence water excretion in man."
      https://pubmed.ncbi.nlm.nih.gov/870513/

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      • alfredoolivasA Offline
        alfredoolivas
        last edited by alfredoolivas

        Prolactin group had much lower estradiol, but the before measurements were not taken

        https://clinicaltrials.gov/study/NCT00438490?tab=results#results-overview

        b9b35925-d2d6-4a82-a21a-5d10cb1f8980-image.png

        https://pmc.ncbi.nlm.nih.gov/articles/PMC1950489/#sec10

        Prolactin group had constantly lower estradiol

        22a17dd3-15b4-45d4-8ddb-9b4ce200582d-image.png
        Prolactin group ate less

        00c2a08c-5c05-4b81-b71b-c7ad188be488-image.png

        02534d1d-c047-4b11-98ad-7bad30f2cedf-image.png

        "Short-term prolactin administration causes expressible galactorrhea but does not affect bone turnover:"

        engineerE 1 Reply Last reply Reply Quote 0
        • engineerE Offline
          engineer @alfredoolivas
          last edited by

          @alfredoolivas so with how good prolactin is, tell us why we shouldn't prolactinmaxx (you know how)

          alfredoolivasA 1 Reply Last reply Reply Quote 0
          • alfredoolivasA Offline
            alfredoolivas @engineer
            last edited by

            @engineer I have been doing that with great results.

            E 1 Reply Last reply Reply Quote 0
            • E Offline
              Ecstatic_Hamster @alfredoolivas
              last edited by

              thank you all for this incredibly valuable thread. @alfredoolivas thanks for starting it.

              I suppose like estrogen, prolactin has its good sides. This has helped me see some more research material I would have missed that I can study.

              1 Reply Last reply Reply Quote 2
              • alfredoolivasA Offline
                alfredoolivas
                last edited by

                After quitting cabergoline, my tiredness has stoppped

                engineerE 1 Reply Last reply Reply Quote 1
                • engineerE Offline
                  engineer @alfredoolivas
                  last edited by

                  @alfredoolivas at this point I would be worried about not getting in enough food or at least not carb cycling (to lose fat by maximizing carbs only when absolutely needed), because you can feel "not tired" through cortisol which could have been suppressed with cabergoline

                  alfredoolivasA 1 Reply Last reply Reply Quote 1
                  • alfredoolivasA Offline
                    alfredoolivas @engineer
                    last edited by

                    @engineer cabergoline increases noradrenaline though.

                    1 Reply Last reply Reply Quote 1
                    • alfredoolivasA Offline
                      alfredoolivas
                      last edited by

                      “PRL stimulates steroidogenesis in the testes by inducing or maintaining LH receptors in Leydig cells and/or by affecting androgen biosynthesis in Leydig cells via steroidogenic enzymes activity”

                      https://pmc.ncbi.nlm.nih.gov/articles/PMC10637432/

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                      • KvirionK Offline
                        Kvirion
                        last edited by

                        "The dose makes the poison."

                        "Alle Dinge sind Gift, und nichts ist ohne Gift; allein die Dosis macht, daß ein Ding kein Gift ist." ~Paracelsus

                        A little learning is a dangerous thing ;
                        Drink deep, or taste not the Pierian spring :
                        There shallow draughts intoxicate the brain,
                        And drinking largely sobers us again.
                        ~Alexander Pope, An Essay on Criticism

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