@gentlepotato I'm sorry, I don't have a lot of mental energy to research anything currently. Would you mind sharing with me some basics or a protocol that can help with the energy production that is blocked due to the Itaconate shunt? Are there some simple things that can help, or is it very complicated? I am about 2.5 months into glucose therapy (15 Tbsp doses), and I'm not doing well. I have tried countless complicated healing regimens over the years, and the simplicity of glucose speaks to me. Unfortunately, it's not working (yet). If you could point me in the right direction on this, I would appreciate it.

Can someone please fill me in on the thought process behind oral H2O2 therapy and a good resource(s) to learn more about it? I assume one of the benefits is to improve overall tissue oxygen levels within the body?

@S-Holmes I'm not sure about this. I haven't heard that it matters. Ozone is O3 (three oxygen atoms), so technically made "with oxygen."

@CrumblingCookie said in Glucose loading cures everything?:

@GlucoseOrBust said:

For what it's worth, Stephens talks about glucose, oxygen, and water being the three critical factors of energy metabolism.

I think this is an oversimplification, as studying things like Buyteyko breathing shows that air hunger is a subjective experience based on an individuals tolerance to CO2 build up in the lungs and blood.

! Thanks. Wow. It fits together. Now I feel the need to read up on Buyteyko breathing.
I've heard military special forces apply very specific breathing techniques in high-stress situations which probably limit the glucose-inhibiting aftermaths. Is that the Buteyko?

Buteyko is about reducing the volume of each breath in and out your nose. Over time, this resets you CO2 tolerance (level at which you experience air hunger) and allows you to breathe less air breathing less air allows more carbon dioxide to remain in the blood, which transports more oxygen from the blood into cells.

@S-Holmes The smell of ozone coming off of these suppositories is overwhelming. Not to be gross, but the little bit that you get on your fingers stays there for hours. The ozone is extremely strong. Also, (incoming grossness again), your BMs after using the ozone smell like ozone and have no typical BM foul smell to them whatsoever. The ozone concentration is plenty high, at least with regards to the highly unscientific smell test..... sorry

@S-Holmes Neither.

https://shop.puro3.com/puro3-ozonated-oil-suppositories-10-or-30/

For what it's worth, Stephens talks about glucose, oxygen, and water being the three critical factors of energy metabolism. I know it's not groundbreaking science, but maybe a good reminder as to how healing could be more simple if we look at the macro picture first. Anyway, he says that oxygen and water optimization are easier to diagnose as we get clearer signals from the body that we are deficient (air hunger and thirst to put it simply). I think this is an oversimplification, as studying things like Buyteyko breathing shows that air hunger is a subjective experience based on an individuals tolerance to CO2 build up in the lungs and blood. Buteyko helps to reset this air hunger set point to allow greater CO2 in the blood, which paradoxically allows MORE oxygen to be taken up by the cells. Also, it seems that chronic dehydration without a persistent thirst signal is also quite common, at least with regards to lab biomarkers indicating such.

Dr. Stephens is clearly onto something with dextrose in large-ish doses with regards to healing. I think he has seen countless miracles with it, but has put together a kind of patchwork theory on how it works after the fact. I think the danger in this is that there are still people with whom large doses of dextrose are not helping after many weeks, and the answer to why it isn't working probably isn't as simple as more dextrose or time is needed. For me, I've gone as high as 24 Tbsp in one dose and I've been on the protocol now for 7 weeks. I think I have explored a reasonable range regarding both dosage and time needed to at least see marginal benefits. I think it would be a safer for him to assume that there is a minority of people that will either respond slowly (or possibly not at all) to pure dextrose loading. Keeping it simple is good and I think the right path. Perhaps this is a bit too simple, however.

I think it's once people have explored high dosing and have given it a month or more that Stephens has lost most of his patients (the 15-20% or so he's mentioned that don't end up sticking to the program. Some people give up, because they are in a cycle of trying one thing after the other out of desperation. I've definitely been there, but not with this one I don't think. I think there has to be another factor that could be limiting this glucose uptake or glucose metabolism in the brain, especially for the most severe cases. Proper oxygenation seems like as good of a candidate as any. I like the idea of experimenting with ozone. I have done ozone suppositories in the past with little benefit, but I wonder if combining them with dextrose could be beneficial? This combined with low dose MB (I've taken the dosage down to 3mg x2 per day) could be helpful. Any thoughts?

@gentlepotato Amazing results! Very happy for you. Thanks for the reminders and tips on checking metabolic markers along the way

@S-Holmes I appreciate you. I hope you get through your trials and out the other end with all the lessons and none of the suffering.

I'm in pretty horrible shape. I am getting ready to reach out to Dr. Stephens, but I just saw your post. I am emotionally breaking down, and I don't know what to do. I don't really blame the glucose, as my life keeps getting more and more desperate with or without it. It's been six weeks, and I haven't really seen it make a positive difference in any of my symptoms. If anything, everything is slightly worse. I just don't have the strength to push through much longer. His results have been literally unbelievable, but I keep thinking that it can't work for everyone. That's where I am at currently. I hope to snap out of it and find some kind of stable footing.