@GreekDemiGod I think @T-3 pushed through this and found success.

@CrumblingCookie Would you recommend someone trying to diagnose if they need more Cysteine to take NAC? If yes, just as a diagnostic tool or ok as a regular/intermittent supplement?

@oskaar23 Yes it definitely seems very beneficial from a bioenergetic perspective. Some of these beneficial compounds/hormones are helpful in the context of a euthyroid state, however. For example DHEA or high-dose Pregnenolone can sometimes backfire in a stressed human (from the many anecdotal reports), increasing unwanted symptoms (but often still ameliorating others).

@risingfire No experience, just curious about this.

@GreekDemiGod Why not try 2:1 or 1:1 ratio T4/T3?

@GRay It's not always better. Some people get anxiety from methylated vitamins, others don't. Others still do good with methylated forms but experience an initial period of depression, and so on. I wouldn't overthink it, especially when taking a B-complex which can provide balance such that most issues are mitigated. And going down the rabbithole of methylation, in my experience, is one of the lowest ROI avenues for personal nutrition research one can go down (the best to get out of it is the right/non-toxic forms of various B's, especially B9 and B12—I'll save you the trouble: calcium folinate or MTHF (methylated), and adenosylcobalamin/hydroxycobalamin or methylcobalamin (methylated)). Elliot Overton of Objective Nutrients basically did the research for you for the "best forms" depending on what you want with his two B-complexes—maybe the best path for self-experimentation with this would be to try his non-methylated complex first then the methylated.

With the methylated stuff I tend to get weird agitation symptoms after many repeated days of dosing, but I still get noticeable benefit (energy, focus) from the complex, so I take it up to 3x per week. Any issues resolve within a day of ceasing supplementation. Vitamin A, Glycine, and Niacinamide are methyl buffers if you ever get what you suspect to be overmethylation symptoms.

For B-vitamins: Energin, ATP Labs Methyl-SynerB, Objective Nutrients has clean methylated and non-methylated options.

@risingfire If one is, say, low on thyroid hormones, or has low body temps, or has high rT3, would exogenous DHT worsen one's condition (in any way—say, more likely to lose hair) or better it? Hypothyroidism is correlated with higher prolactin, estrogen, and cortisol, so the question could also be framed in the context of whether artificially increasing DHT is bad or good in the presence of these stress hormones. I'm not sure we have all the data but I'm curious if anyone out there knows or if there are any anecdote-driven consensus etc..

I know that optimal thyroid can greatly increase Testosterone and DHT, so I'm curious if it's harmful to increase DHT without optimal thyroid—whether it would help or suppress the thyroid.

Is there any risk to taking exogenous DHT in a hypothyroid state? or would it be of benefit to the person?

@William-Shat I believe Serotonin heightens the voice and makes it sound frail, fragile, and less soothing. And not a heightening such that it sounds childlike; more making it softer and higher pitched. I've listened to videos of myself in dark times, and have "diagnosed" family members on their bad days by the height of their voice (men only), which maybe could mean that thyroid is responsible and not serotonin, but this is just my instinct.