extremely real, my skull and bone all became thicker when i first started peating.
Latest posts made by cupofcoffee
-
RE: High Serotonin = Weaker Bones
-
RE: Is Cialis/Tadalafil Harmful?
@Birk extremely real, but try other pro-erection stuff first.
on RPF, haidut mentioned how aspirin can help erections and i concur
-
RE: Is Cialis/Tadalafil Harmful?
they will speed up aging and cause oxidative damage
-
Aspirin raises neuroplasticity
One of of the supposed "benefits" of antidepressants is increased neuroplasticity. Well, aspirin does just that without the cuck side effects
https://pubmed.ncbi.nlm.nih.gov/30012602/
Despite its long history, until now, no receptor has been identified for aspirin, one of the most widely used medicines worldwide. Here we report that peroxisome proliferator-activated receptor alpha (PPARα), a nuclear hormone receptor involved in fatty acid metabolism, serves as a receptor of aspirin. Detailed proteomic analyses including cheminformatics, thermal shift assays, and TR-FRET revealed that aspirin, but not other structural homologs, acts as a PPARα ligand through direct binding at the Tyr314 residue of the PPARα ligand-binding domain. On binding to PPARα, aspirin stimulated hippocampal plasticity via transcriptional activation of cAMP response element-binding protein (CREB). Finally, hippocampus-dependent behavioral analyses, calcium influx assays in hippocampal slices and quantification of dendritic spines demonstrated that low-dose aspirin treatment improved hippocampal plasticity and memory in FAD5X mice, but not in FAD5X/Ppara-null mice. These findings highlight a property of aspirin: stimulating hippocampal plasticity via direct interaction with PPARα.
-
RE: Trenbolone Peaty?
AFAIK trenbolone has weird progestin-like activity, which is never a good thing (progestins are harmful and counterproductive, compared to progesterone)