Topics created by Galaroc

@Galaroc Get sunlight, eat good food, stay active and surround yourself with loved ones. Maybe get a dog to keep him company haha

@Galaroc wow thanks a ton. Very appreciated. I need to dive into that research.

@Galaroc i tried it but didnt notice benefits (maybe other problems meaning benefits couldnt be gained or maybe my coq10 synthesis is good and not a limiting factor for energy production for me?). apparently its good with heart failure

sounds like there is some "programmed in" thinking mixed into that? like theres some sort of counter for atp that when it hits mitochondria stop or something? as speculation.
but mitochondria repair / replace in right conditions, co2/atp production clearly dynamic, older age people sill respond positively to supplements that influence mitochondria etc

but haidut posted this http://haidut.me/?p=2144 highlighting the type of metabolism increase is important .
someone can have high metabolism but be excessively uncoupled (i.e low functioning of the last part of the Electron Transport Chain in mitochondria), so lacking atp production, or someone can have high metabolism but atp produced from glycolysis without the co2 benefits u get from mitochondria linked metabolism so worsen longevity. or another factor could be ramping up the ETC too much for what the cell can handle with current factors (too much ROS production in the process), where milder increase could be protective

increased co2 production in cells from increased metabolic rate is an important factor in aging / longevity
ray mentioned some stuff on that in https://raypeat.com/articles/articles/salt.shtml

@Galaroc said in Niacinimide for PUFA depletion:

Hello gentlemen,

I am currently in Guatemala and am living with a host family. Trying to keep peaty and am managing well but PUFA intake is currently non-zero. Have access to aspirin but not K2 and therefor hesitate to blast a lot of it to mitigate the PUFA I’m taking in.

I am interested in niacinimide as an option for mitigation. I have some energin with me and have been using it regularly (I am totally yellow) but I’d like to explore niacinimide specifically.

Anyone have recommendations for brands/dosing/overall protocol for PUFA depletion and management?

Ray Peat preferred smaller doses of niacinamide taken more frequently. I currently take 100mg of niacinamide, 4Xday. Niacinamide is water soluble so it only stays in the body for a couple of hours. I use the purebulk.com niacinamide.

Another thing that Ray Peat suggested taking is some vitamin E. Perhaps somebody can chime in regarding the amount and the timing? I think the goal is to get the vitamin E into your stomach at the same time as the ingested pufa so it can saturate it and make it safer. Sorry, I don't know the amount of vitamin E needed. I suspect a small dose though. Maybe you can find info about it here.