My little bro is going through a very traumatic break up with his first serious girlfriend. Any suggestions on what to give him as general anxiolytics, sleep aids and brain support? Looking for acute and systemic interventions.

@LetTheRedeemed

I have seen a number of references to Ray saying that on the old forum but I can’t find a source where he actually does. He mentions succinic acid, along with citric acid and other types being a chelator in Generative Energy #55 but only in passing when discussing how sour orange juice can often be irritating for people as the increased citric acid chelates tissue bound heavy metals causing distress. Quote is from 1:12 in the episode linked below:

https://raw.githubusercontent.com/0x2447196/raypeatarchive/main/transcripts/%252355：%2520Bioenergetic%2520Nutrition%2520Basics%2520｜%2520＂The%2520Ray%2520Peat%2520Diet＂%2520｜%2520Appetite%2520and%2520Metabolism%2520with%2520Ray%2520Peat%2520%255Bf06rVi8iXfI%255D.vtt

Further mentions from the forum:

https://raypeatforum.com/community/threads/what-do-you-know-about-succinic-acid.14920/

https://raypeatforum.com/community/threads/succinic-acid-for-heavy-metal-detox.4970/

Lots on this on the old forum but I’ll keep looking for that recommendation from Dr Peat. Link in the first forum post is broken.

@cs3000

Thank you for the great links! I was not seriously considering using EDTA or another real chelator as I don't have extreme or acute symptoms.

In summary a recommended protocol is:

• Thiamine HCL 100mg 2x per day (cannot not use benfotiamine, must be HCL as benfo is lacking the sulfur atom which reacts with the lead)
• Zinc gluconate 30mg per day
• Selenomethionine 150mcg per day (recommended to use products from Sabinsa Corp with SeLECT, sold by Swanson or Vitacost that state: "Selenium from (as) Selenium SeLECT L-selenomethionine")

Additional but not required, though highly effective if you have acute expsosure:

• Modified Citrus Pectin (MCP) 15g per day in 3 5g doses (PectaSol brand) for 28 days

You will need to run the primary protocol for at least 9 months in accordance with the studies to get the required results, but the pectin shows rapid chelation (reduction of levels in children of 161%) in just 28 days. I think this may be because the kids were badly exposed and had very high levels.

I also just read that Ray has recommended succinic acid at 200mg twice daily in a capsule form for two weeks to clear out heavy metals. Have you heard anything about this method? Still looking into it now.

I have learned that I was exposed to lead in the past through an HTMA test. My hair levels are high (6 parts per million - a strange choice of unit but used on the HTMA) but not astronomical, and my blood levels are nonzero but within the reference range (0.04 umol/L). I suspect I was exposed through living for some time in Central America, or through the pipes in an old house I was living in for 2 years where I drank from the tap.

Of course zero lead in the body is ideal, but are these levels anything to be concerned about? What can or should I do for chelation? I am considering phlebotomy as a first step to try and clear at least some of the lead out of my blood.

The HTMA is 1 month old and bloods were taken one week ago.

@cs3000 Fascinating, I had no idea it played such an important role. Do you supplement or otherwise prioritize CoQ10? I think I should be getting a sufficient amount from 400g liver weekly and the resulting downstream metabolism of the nutrients within.

Interesting to see the researchers explicitly discuss the mitochondrial theory of aging with increasing DNA damage and impairment of DNA repair being the hallmark of "aging".

"The results of this study correlate with the “maximum metabolic slope theory” by Prinzinger that suggests a correlation between life span and energy production."

Sounds familiar. Have you heard of this theory? I am just beginning to research it now.

I was researching Vitamin K2 and came across the following article regarding its interaction at a cellular level with CoQ10 to produce ATP, and how K2 cannot replace it within the mitochondria ie. it is required for ATP production. The article also notes the extreme nonbioavailability of CoQ10 ingested orally with effective supplementation requiring 30-50mg / kg daily, equating to minimum 3g per day for a 100kg man. Given that the richest foods containing CoQ10 such as beef heart and liver have only about 11mg per 100g, is it possible that that this is a commonly missed pathway to more energy? The typical western diet has insignificant amounts of both K2 and CoQ10 and, the Faustian Peater (RIP) within me is curious if anyone has ever tried an aggressive K2 and CoQ10 regime, or has heard any anecdotes about it being tried.

https://www.researchgate.net/publication/332642560_Vitamin_K2_cannot_substitute_Coenzyme_Q10_as_electron_carrier_in_the_mitochondrial_respiratory_chain_of_mammalian_cells

@scamp

FFAs are free fatty acids, with the worst kind being polyunsaturated. They circulate in your blood when consuming higher fat content that is not completely metabolized. The mechanism of action is something I am not sure about, I have heard Ray, Danny and Georgi speak about this in various podcasts. Here are two links to the RPF to start your investigation, the first on FFAs and thyroid and the second on FFAs and aspirin. Keep this thread up as I would love to see what you learn.

https://raypeatforum.com/community/threads/free-fatty-acid-and-thyroid.40311/
https://raypeatforum.com/community/threads/free-fatty-acid-suppression-by-copper-nicotinate-and-salicylates.47975/

@BroJonas @scamp

Second the comment about circulating FFAs, these will complete negate the ability of the body to utilize the T3 when you eat it. How's your diet? Really stressed out? You could try a few weeks on a zero or very low PUFA diet (ex milk, boiled potatoes, lean beef, gelatin and lots of carrot salad) to see if the digestion improves and the T3 becomes effective.

@AinmBeo

I am highly interested in hearing about how you do this.

@Mauritio

I am familiar with this particular strain as I recall hearing Bronze Age Pervert speak about the Gastrus product as far back as 2022 or earlier, and he reports similar virilizing effects. Thank you for posting these studies, I had never seen anything on it quantified like this.

@laoa I’ve been active with the coco oil but hadn’t given it to my host mom to cook with. I’ll do so in the future. Curious about your vitamin e intake in a high PUFA environment - what kind of dosage? Full blast of tocovit (400iu) ED or EOD?