@questforhealth My humble thought tells me that any oral chelation you want to undertake without monitoring through targeted tests such as hair combined with serum, plasma, biopsy will lead you into a confusing and discouraging loop simply because you are relying on something acute. Some experts claimed that even if you keep daily Chelation active, what enters your body will always be greater than what goes out. Thought to ponder.

@Mulloch94 Perhaps you miss a fundamental step that by the time the substance leaves the system the final acetylcholine will perhaps be higher than before. Do you understand what I mean? a typical example is when you use Cypro for example you might feel terrible during it but when it comes out you will feel better due to a matter of receptor under-regulation and over-regulation. I gave a random example but it could apply to anything we introduce. I absolutely need to reactivate acetylcholinesterase or antagonize whatever is blocking the enzyme. They mention atropine scopolamine but the hospital should do it, not me!

@Korven Hi, it's the usual diet with the usual foods except vegetable oils and dried fruit. I've never had a problem with eggs and nightshades. The most serious problem is not being credible in two hospitals because they are based on the muscle biopsy I did and therefore interpret the symptoms only as general worsening (even the neurologist). Quite frustrating because they are typical symptoms of cholinergic syndrome/intoxication (from an external agent). Add to that the fact that I already have a weakened brain and muscles, we say putting fuel on the fire. .

@Yenn Diarrhea alternating with constipation, sensation of not breathing even if saturation remains normal, insomnia, vivid dreams when I fall asleep, alertness, asthenia, decreased muscle tone, confusione, all of which would correspond to a cholinergic crisis induced by acetylcholinesterase blockade ️️️

@Appa Thanks, it sounds like there's something inhibiting it. the hospital didn't give any importance but if the symptoms continue I will have to return in the meantime I have also tried chelators such as zeolite, NAC and alpha lipoic acid but I suspect something highly selective is needed

@Mulloch94 Hi, I did serum tests and cholinesterase is in the low threshold. I should have the erythrocyte test on Monday. There is something that is non-reversibly blocking the enzyme ️. In the meantime, I no longer know how to manage the symptoms. It's hellish because I've already had chronic degenerative processes for many years. At home I have magnesium bisglycinate with P5P, magnesium Epson (sulfate). Can they help as you kindly indicated? NAC seemed to help increase acetylcholinesterase activity but now after a few days it stopped working, as did lipoic acid.

@mostlylurking

Thank you so does B1 not necessarily increase choline or rather does it increase final degradation if acetylcholinesterase rises?

Nothing ? ️

@Verdad said in Endurance exercise causes (peripheral) hyper-cortisol state:

Fascinating study thank you for sharing Haidut. I guess this would partially explain why so many people after they stop exercising very quickly gain all the weight that they lost.

Not necessarily but one of the many consequences certainly together with a slowdown of the thyroid and a transition to slow oxidation.

Hi everyone, for several weeks I have been experiencing symptoms of high acetylcholine as if the acetylcholinesterase enzyme was inhibited but not reversibly because otherwise the situation would return to normal in 2-3 days. Is there something that can be done to "unblock" this enzyme and promote the regular metabolism of acetylcholine? thank you all happy to be here too.