Posts made by LucH

@mostlylurking

I agree with your analyze on excess serotonin and 5-HTP (targeting SSRI, thus increasing central nervous system synthesis of serotonin).
SSRI = Selective Serotonin Reuptake Inhibitor.
Saying that, prucalorid is taken, not as a laxative – at the usual dose of 2 mg – but as a stimulus (0.5 mg resolor). The dose is very weak but sufficient for re-educating a lazy gut.
Here we’re trying to find a solution for colonic motility dysfunction. And the solution has not to be found with a laxative. This is not because of a lack of electrolytes, fibbers or exercises. By the way, 30 grams fibbers is needed, with soothed fibbers (progressive).
When suffering from insufficient electrical contractile bowel movements, between 2 meals, we aren’t targeting a problem of transit. The muscle contractions are called peristalsis. This process must be re-educated. Of course, the IBS problem (high-amplitude propagating contractions) must be taken into account. First calming down irritation, afterwards stimulation of the stasis.
Note that when I took resolor 0.5 mg, I took it 2 hours before bedtime (3-4 days adaptation period).
A box of 28 tablets cut into two parts = 56 days of treatment (cut with a sharp kitchen knife). No need for a second box.
Once a day for stools wasn’t enough to get rid of excess / unbalanced intestinal bacteria. Some bacteria had nothing to do in the second part of the colon.
The problem in now under control, with the help of diamine oxidase. Too much histamine. (NaturDAO, 1 000 000 units).
Note: The warning concerns the usual employment to a high dosage of 5-HTP and against an excess of serotonin. The excesses are obviously counterproductive. Here, it is rather a homeopathic treatment / dosage. The difference between a poisoning treatment and a treatment that stimulates. Only the dose makes the poison. I would add the duration too.

@OrpingtonClose said in Whats the deal with "Vitamin" A?:

Is it good or bad?
Here is some info I collected through my decoder
Note that all people won’t agree with what follows.
*) ## High intake of vitamin D (5 000 UI) or a deficiency of Retinol
An excessive intake of vitamin A (retinol) can cause a deficit of Vit D by antagonism. U-shape activity. Retinol (the active form of vitamin A) is an antagonist of vitamin an excess or a deficiency of one or the other of these vitamins will counteract the functioning of the VDR receptors, leaving them unoccupied or inactive.
Moreover “Any intracellular capable of producing a substance that blocks the VDR would have an effective strategy for disabling the immune system!”
https://mpkb.org/home/pathogenesis/vitamind/metabolism
Excerpt: Bacteria and the VDR
Hormonal changes result from change in 1,25 dihydroxyvitamin-D
*) Technical explanation, in short.
An excess of vitamin A (or a vitamin D deficiency) prevents the formation of heterodimers: essentially homodimers (RXR-RXR) will be formed, leaving the VDR unoccupied and inactive.
Source: Zoëhlo (French Pharmacologist)

*) I eat once a week 2 chicken livers (lightly roasted, with one onion), in 250 ml soup. Or I take 10 000 UI retinyl palmitate (once softgel) with a meal (fat required).
It’s not a good idea to take more than 3 000 mcg in once. The Tolerable Upper Intake Level (UL) for adults is set at 3,000 μg/day. Most vitamin A is stored in the liver. ## The half-life of vitamin A is estimated to be 128 days, so it can take many months for retinol levels to normalize after vitamin A toxicity. (4)
10 000 UI = 3 mg = 3 000 mcg
Conversion :
*) Retinol: UI in mcg => x 0.33.
6 000 of retinol Estroban x 0.33 = 1980 mcg.
4. Institute of Medicine (US) Panel on Micronutrients
Dietary reference intakes for vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc. Washington, DC: National Academies Press (US); 2001. Google Scholar
*) Vitamin A has effects of thyroid hormone
Vitamin A lowered TSH and increased T3 in both lean and obese humans. “The effects of vitamin A supplementation parallel the effects of supplementing T3 - i.e. lower TSH and T4 and higher T3 levels”. Haidut
http://www.ncbi.nlm.nih.gov/pubmed/23378454

*) ## Interaction between fat-soluble vitamins
Vitamin K2 is the substance that allows dependent proteins A and D to be activated / come to life. While vitamins A and D act as signaling molecules, indicating to the cells to produce certain proteins, vitamin K2 activates these proteins by giving them the physical capacity to link calcium.
In order to truly understand the fat-soluble vitamins, however, we must understand that vitamins A, D, and K cooperate synergistically not only with each other, but also with essential minerals like magnesium and zinc, with dietary fat, and with key metabolic factors like carbon dioxide and thyroid hormone.
Useful info:
https://mirzoune-ciboulette.forumactif.org/t2017-english-language-corner-1-liposoluble-vitamins#29442
https://mirzoune-ciboulette.forumactif.org/t667-vitamine-a-sous-estimee#5923 (studies links)

• Bioconversion of dietary pro-vitamin A carotenoids to vitamin A in humans
• Half-life of carotene
• The Role of Retinoic Acid in Tolerance and Immunity
• Vitamin A (retinol) is Endotoxin (LPS / TLR4) Antagonist.
  Note:
• Hypothyroidism can lead most people to a vitamin A deficiency (especially in vegetarian).
• Vitamin A is one of the Keys to a Tolerant Immune System?
  https://mirzoune-ciboulette.forumactif.org/t721-vitamine-a-la-cle-dun-systeme-immunitaire-tolerant#6555

• Vitamin A works as an estrogen antagonist

The greatest use of vitamin A is at the level of production of pregnenolone, progesterone and the other steroid hormones associated with youth.
“Vitamin A is for the production of pregnenolone, progesterone, and the other youth-associated steroids”. http://raypeat.com/articles/articles/alzheimers2.shtml

@mostlylurking said in High-dose thiamine troubleshooting:

Please tell me what is "MMC"

The migrating motor complex (MMC) is an electrical and contractile activity of digestive motility which takes place in the inter-digestive periods (between two meals), and interrupted by food intake. Each MMC is accompanied by an increase in gastric, pancreatic and duodenal secretions. They are thought to serve to evacuate contents in the small intestine between meals, and also to transport bacteria from the small intestine into the colon. An alteration of this phase notably favors the development of chronic bacterial colonization of the small intestine, a source in particular of bloating, diarrhea, or even steatorrhea, of the majority of food intolerances. When contractile activity is low, we then speak of lazy intestines. Support and rehabilitation is often necessary, with a prokinetic (Resolor 0.5 mg), initially.

We’ll have to work on## 4 levels:

• Thyroid for energy
• Dysbiosis for microbiome (the microbiote is 70 – 80 % of immunity).
• Leaky gut and foodstuff tolerance
• MMC to get rid of stasis and the disadvantages resulting from bacterial overwhelming. Mind this point (inter-digestive motility) or otherwise we won’t see the end of the tunnel. See beneath for details.

*) Amizon says:
“I’m attempting to treat more-or-less lifelong chronic fatigue issues”
=> The thyroid acts as the carburetor of a car. Energy level.
*) Amizon says:
“Any suggestions would be much appreciated, thanks”.
=> I’ll take a Vitamin B complex 2x/w (3x at the beginning). A co-enzymed form.
*) Amizon says:
My digestion is still super out of sorts.
I wouldn't have called my gut sensitive--just constipated. Slow slow bowels my whole life.
=> Get informed on MMC. If you …
*) Amizon says:
"I started having gastritis (…) Things have been much funkier and more sensitive since then in the gut department. A low fodmap diet did [seem to] solve the problem. (…)
If I eat more than incidental amounts or frequency of FODMAPs, I get gastric pain and fibromyalgia symptoms. If I follow my restricted diet my symptom set is more chronic fatigue, very little pain. The only thing that helps the constipation though is miralax. All of this low energy and constipation is one of the main things that had me interested in the high-dose thiamine therapy."
Answer

We’ll have to work on 4 levels:

• thyroid for energy
• dysbiosis for microbiome (the microbiote is 70 – 80 % of immunity).
• MMC to get rid of stasis and the disadvantages resulting from bacterial overwhelming.
  Mind this last point (inter-digestive motility) or otherwise we won’t see the end of the tunnel. See beneath for details.

Read the following info too and come back to discuss and have a plan.
*) The English Corner: Auto immune reaction
Intolerant to foodstuff – Severe Dysfunctional Digestive System
https://mirzoune-ciboulette.forumactif.org/t2022-the-english-corner-auto-immune-reaction#29492
*) Cereals and pseudo-cereals
As far as vegetables are concerned, raw for enzymes but not at the beginning when your bowels are irritated. We’d better eat them steam-cooked and according to what you can tolerate. Adapt yourself.
As far as pseudo-cereals are concerned, they are admitted but moderately. I advise to limit them once a day, a small portion. Buckwheat and rice do contain antinutrients. Like all cereals.
Not good for endothelial cells. Cereals cause zonulin secretion. Zonulin increases intestinal permeability (leaky gut). Tight junctions are no longer operational (by people suffering from poor digestion).
As far as I’m concerned, I try to limit cereals. Let’s say 2x/3 because I’m not perfect
Additional link if you want to know why grains are not advised.
“Why grains are bad?”
http://www.thepaleomom.com/2012/03/how-do-grains-legumes-and-dairy-cause.html
From “How Do Grains, Legumes and Dairy Cause a Leaky Gut?” Part 1: Lectins.

• Part 2: Saponins and Protease Inhibitors of grains and legumes
  From “How Do Grains, Legumes and Dairy Cause a Leaky Gut?”
  http://www.thepaleomom.com/2012/03/how-do-grains-legumes-and-dairy-cause_29.html

*) The migrating motor complex (MMC) is an electrical and contractile activity of digestive motility which takes place in the inter-digestive periods (between two meals), and interrupted by food intake. Each MMC is accompanied by an increase in gastric, pancreatic and duodenal secretions. They are thought to serve to evacuate contents in the small intestine between meals, and also to transport bacteria from the small intestine into the colon. An alteration of this phase notably favors the development of chronic bacterial colonization of the small intestine, a source in particular of bloating, diarrhea, or even steatorrhea, of the majority of food intolerances. When contractile activity is low, we then speak of lazy intestines. Support and rehabilitation is often necessary, with a prokinetic (Resolor 0.5 mg), initially.

@LucH said in High-dose thiamine troubleshooting:

-) English corner. Potential roles of Vit B6 in inflammation and immunity
https://mirzoune-ciboulette.forumactif.org/t2034-english-corner-potential-roles-of-vit-b6-in-inflammation-and-immunity#29633

I’m going to put some points in excerpt. I’ll develop if you are interested in.
Mind the following behavior: If you don’t agree now with one point, don’t throw away the baby with the bath-water. You may disagree but you have to say why if you want some help.
I’m not a nutritionist. I’m a teacher and I’m the administrator of a French site based on health and nutrition.
*) Former take of high dose thiamine HCL.
High dose Thiamine must be taken with some B2. Doses progressively raised. High dose thiamine has an impact on the detox pathway and histamine degradation (Cyp450 enzymatic pathway).
There is interaction between other B vitamins, especially B1 B2 B3 for glycemia. If you take B3 (niacinamide to avoid a flash reaction), you’ll need B6 + probably a methyl support (TMG) according to the type of B3. If you take B6, PLP mustn’t exceed a threshold, depending on the consumption by the body (low grade inflammation, immune reaction). Otherwise, you’ll get a problem with GABA-like symptoms (depravation) (a lack of / shortage due to a protection process of the brain: Too much of a good thing is bad).

B6 is needed / required for brain balance in the event of problems like you described. Vitamin B6 is well documented for its role as a modulator of steroid hormones: This vitamin contributes to the proper functioning of the nervous system. It participates in the synthesis of neurotransmitters, such as serotonin and dopamine, who play a crucial role in the regulation of mood, sleep and mental well-being.

But if you suffer from inflammation (low grade inflammation from bowel irritation or arthrosis if you are over 35 years old), your B6 will be burnt / exhausted.

Useful info (to read later)
-) English Corner – Vit B6: How much is too much?
https://mirzoune-ciboulette.forumactif.org/t2033-english-corner-vit-b6-how-much-is-too-much#29628
-) B6 modulates the activity of GABA. B6 as antioxidant and antipain.
https://mirzoune-ciboulette.forumactif.org/t2041-english-corner-b6-leads-to-decrease-of-cytokines-in-neuropathy#29659
-) English corner. Potential roles of Vit B6 in inflammation and immunity

@amizon said in High-dose thiamine troubleshooting:

my silly sensitive gut--and see if that can help my digestion and liver out,

Give details, please:
Dysbiosis (flatulence, gaz, bile, etc.). What about the MMC and the feces (2x/day)?

Need to follow a relaxation therapy, perhaps with supplements to optimize GABA (collagen, L-theanine,) + magnesium bisglycinate.
First soothing gut and stomach linings before eating carrot salad.
Need some glutamine too but not if dysbiosis.
Hope it will help.

@amizon said in High-dose thiamine troubleshooting:

Any suggestions would be much appreciated, thanks.

Hi, every body (1st post).
Too much thiamine could occasion issues related to histamine and acetylcholine excess that doesn’t make sense immediately. High level thiamine is a burden for the detox system CYP450.
Moreover we need some B2 after a while when taking B1 supplement. Mostlylurking has explained it very well. Thanks, by the way. B2 is not required every day.
And by the way, I read a post from redsun on RP forum (where I no longer go to), saying B6 could counteract symptoms brought by disorder from GABA and serotonin.
Mind the kind of B6. No pyridoxine (PNP). PLP must be taken with pause. I can explain how I did, if you want.

LucH