Thanks for sharing.
I actually look at the opposing actions of M1 and M2 macrophages with a grain of salt. The use of M1 and M2 macrophages to explain away the harm in using PUFAs by the notion of omega-6 being contributory to the M1 inflammatory response, and omega-3 being conducive to an anti-inflammatory response, thus bringing about a healthy balancing of the immune response- is downright mendacity by medical researchers.
Thanks to Ray Peat we don't buy that medical narrative. I hope tou understand how much I question their once again. using M1 and M2 to explain the benefits of baking soda in treating the inflammatory response involved in arthritis.
Add: Pre-Peat I took omega-3 to balance inflammatory effects of omega-6, which together formed the heart healthy core of the AHA, which was very influential in causing their factotum CSPI to lead a heart-healthy crusade against beef tallow as used then by McDonald's to deepfry French fries.
Back then, Udo Erasmus was very popular with his book "Fats that Heal, Fats that Kill." That book led in establishing the mainstream discourse that PUFAd are good because of the anti and pro-inflammatory tandem duality or omega 3 together with omega 6.