I can say that PUFA was the major change that had the most impact on me. I was very strict on it, considering as poison actually.
But years prior to PUFA restriction, I had all my mercury amalgams replaced and after that underwent IV chelation to rid my body of mercury toxicity. What this did was to improve my tissue oxygenation, so I won't be hypoxic and relying on anaerobic glycolysis for energy production. I was making a lot if lactic acid instead of CO2.