@Highserotonin What symptoms are you even experiencing?
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Posts made by Yenn
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RE: Chronic Acetylcholine high
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RE: Temp after breakfast lower than upon waking
“If the night-time stress is very high, the adrenalin will still be high until breakfast, increasing both temperature and pulse rate. The cortisol stimulates the breakdown of muscle tissue and its conversion to energy, so it is thermogenic, for some of the same reasons that food is thermogenic. After eating breakfast, the cortisol (and adrenalin, if it stayed high despite the increased cortisol) will start returning to a more normal, lower level, as the blood sugar is sustained by food, instead of by the stress hormones. In some hypothyroid people, this is a good time to measure the temperature and pulse rate. In a normal person, both temperature and pulse rate rise after breakfast, but in very hypothyroid people either, or both, might fall.” -Ray Peat, PhD
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RE: Temp after breakfast lower than upon waking
It's possible that it's adrenaline/cortisol increasing your temperature while you're fasting overnight and then when you finally eat food they are lowered. How does your pulse change?
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Hydroxyzine
"Hydroxyzine's predominant mechanism of action is as a potent and selective histamine H1 receptor inverse agonist.[44][45] This action is responsible for its antihistamine and sedative effects.[44][45] Unlike many other first-generation antihistamines, hydroxyzine has a lower affinity for the muscarinic acetylcholine receptors, and in accordance, has a lower risk of anticholinergic side effects.[41][45][46][47] In addition to its antihistamine activity, hydroxyzine has also been shown to act more weakly as an antagonist of the serotonin 5-HT2A receptor, the dopamine D2 receptor, and the α1-adrenergic receptor.[36][44] Similarly to the atypical antipsychotics, the comparably weak antiserotonergic effects of hydroxyzine likely underlie its usefulness as an anxiolytic.[48] Other antihistamines without such properties have not been found to be effective in the treatment of anxiety.[49]"
Many Peaters know about cyproheptadine but it can be sometimes hard to access, I recently learned about the existence of hydroxyzine and that it's a lot easier to find for me, as it exists on every street pharmacy, is OTC and costs less than 2 euros a pack. It seems to me very similar to cypro, being primarily anti-histamine but also anti-serotonin. It lacks the appetite increase and instead has a very potent anti-anxiety effect and sedation.
"Hydroxyzine is not a cortical depressant, so its sedative properties likely occur at the subcortical level of the CNS. These sedative properties allow activity as an anxiolytic. Antiemetic efficacy is likely secondary to activity at off-targets."
^ means no addiction/downregulation similar to that of benzodiazepinesPrevention of “Learned Helplessness” in the Rat by Hydroxyzine
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RE: Tinnitus remedies?
Ray Peat has only mentioned tinnitus in relation to hypothyroidism and endotoxin, so addressing that is one way to approach the problem.
Yes, many people have told me that when they were given supposedly the right dose of thyroxin, they began getting symptoms like ringing sounds in their ears and prickly sensations, fairly common symptoms of hypothyroidism but they would start when they would go on thyroxin and when they added T3
I think ear ringing from excitotoxicity might require a different approach. Stuff like magnesium, gelatin/glycine, taurine. I've seen cases where people cured tinnitus by acute use of benzodiazepines or ketamine.
Others talk about mechanical causes like TMJ. My anecdote is that tinnitus worsened after I tried Wim Hof breathing which is excitatory. -
RE: Bioenergetic video games?
Most videogames are stimulating to the mind, I'd say what's important for bioenergetics is that you often try new games instead of stagnating into autopilot mode and playing the same stuff all the time, or using them as escapism.
https://scitechdaily.com/research-shows-that-playing-video-games-increases-your-intelligence/
https://whiteoath.net/journal/vidya_nootropic/ -
RE: The internet is dead and shitskins killed it
@bruh Have you tried the carrot salad?