Genetic Scurvy

MostlyCurious

Hello,

As odd as the title sounds I'm dealing with genetic mutations that prevents me from up taking any form of vitamin c through my SVCT pathways.

I discovered this when 6 months ago a blood test taken based on my symptoms showed I had 0.4 vitamin C levels.

I began eating alllllll the oranges, fresh pressing juice, fruit smoothies every day, camu camu, rose hip, pure quali c ascorbic, liposamal, buffered with calcium/sodium, you name it I tried it.

Flash forward and I did the same test again to see how my levels are doing because while I felt better for a time my symptoms slowly came back.

0.2 this time...

So, I dug into my genetics (I have a full in-depth genetic sequencing) and low and behold..

I have a mutation in EVERY SVCT pathway that stops AA from being shuttled into my system.

I then hoped to use dehydroascorbic acid from upping my meat intake as a source (Ray discussed this) and did some more digging but big brick wall because... I also have a GLUT mutation specifically to do with transporting ascorbic acid so I'm also getting very little from meat

So, here's my issue.

The only thing I've seen some improvement with (wound healing/exhaustion/sore teeth/bruises coming back!) is from liposamal BUT the darn choline load in liposamal makes me have such bad OCD and what feels like ADHD after about one month of use.

It gets so bad I have no choice but to stop the liposamal.

I did try, out of desperation, Ascorbyl palmitate (fat soluble synthetic vitamin c), but it messes up my digestive system even in small amounts.

Anyhow, how would you go about off setting the cholines unwanted symptoms? I'm also a slow COMT so it really takes time for my body to process things out.

Honestly, I thought it would be cooler to be a pirate than it is🦜

cs3000

@MostlyCurious hi scopolamine patches or cyproheptadine can inhibit choline signalling , but dosing high can cause issues , and give rebound effects
quinine can inhibit choline signalling (mentioned in hans article) , but looking into the study it would take high amounts for that in the 100s of milligrams, and it has a long half life and that is a toxic dose (might crash testosterone www.researchgate.net/figure/58_tbl2_5454073 and is serotonergic at high milligram dose https://pubmed.ncbi.nlm.nih.gov/1388254/

many things inhibit acetylcholinesterase too (higher acetylcholine) so might be worth getting a list of things to avoid heightening that, or swerve taking those in the PM if overthinking at night

Some targets
https://www.chemistryviews.org/details/ezine/5808971/Vitamin_C_Deficiency__Part_3/

MostlyCurious

@cs3000 Thank you for the resources, I appreciate it.

cs3000

@MostlyCurious yw its a unique situation, would be interesting to see if u solve it

izkrov

lidocaine demethylates DNA, so things like re-occurring rashes and ingrown nails get their "memory cleansed" and stop. I imagine the same applies to genetic mutations. Most things that increase the metabolism have that same mechanism. Progesterone probably too, I'd just take some of that and then hopefully you'll epigenetically adapt.