Methionine/Cysteine restriction increases longetivity AND energy expenditure
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interesting stuff ,
looks like part of the effect is from that increase of thyroid hormone / signallingThyroid hormone increases the FGF21 (but high dose , though does improve with more time, is tissue dependant) https://pubmed.ncbi.nlm.nih.gov/20236931/
& Thyroid hormone also increases the PEPck seen in cysteine restriction
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1135718/
and thyroid hormone & receptor expression is increased by methionine restriction
https://www.sciencedirect.com/science/article/pii/S1756464620300062
main roles Phosphoenolpyruvate Carboxykinase plays https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2785631/
"Self-organizing systems decay only if they have assimilated inertia, and — with a little support of the right kind— the centers of degeneration can become centers of regeneration."
"world," as a source of new perceptions
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My goal has been to have the glycine dominate the other aminos, if that makes sense. So I’m taking more of it. I’m trying to minimize the other ones to some degree.
The glycine has tremendously helped me in a number of areas: improved sleep, improved mood, muscles, skin. It makes you kinda chill…at least it does for me.
I have the MTHFR mutation and Chris Masterjohn says it helps with methylation. That’s another reason I take it.
- An interesting side note: I don’t lift weights, but occasionally I will jump on my Total Gym and do a workout. As a result of taking the increased glycine, It appears that my muscles are more toned and firmer. Without much exercize.
Fyi, I don’t always take straight glycine- I use gelatin and collagen as well. I also don’t always get 20 gms. But I do aim for higher amounts. I mix it in my milk.
- An interesting side note: I don’t lift weights, but occasionally I will jump on my Total Gym and do a workout. As a result of taking the increased glycine, It appears that my muscles are more toned and firmer. Without much exercize.
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I’ve read that thru modern farming practices, our soils are depleted of selenium, so supplementation of it is advantageous.
I take 200 mg. of selenium every few days or so. Then I’ll stop for a week or two so as not to overload my system.
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@cs3000
T3's FGF21 increase depends on PPARa, so we got another player in the game.This is what Travis wrote on the PPARs:
"The activation of the PPAR receptors can be considered a good thing, and their first described function was to upregulate peroxisomes—small subcellular organelles which metabolize excessive prostaglandins and fats. I get the impression that the activation of these could represent the 'resolution stage' of inflammation—an idea which may depend on exactly which subtype of PPAR is activated. I am aware of four types: PPARα, PPARβ, PPARγ, and PPARδ. Of these four, PPARγ get the most attention . . . by far."
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https://www.youtube.com/watch?v=Ag6lNs9KHcQ
How GLYCINE Benefits Your Body (Detoxing Methionine!)
(Not sure how to embed the video)
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@Mauritio
What’s interesting to me is the foods high in cysteine are high Pufa foods:https://veganalyze.com/foods_high_in_cystine_sources_list.html
So another win for avoiding the Pufas.
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@Amethyst said in Methionine/Cysteine restriction increases longetivity AND energy expenditure:
My goal has been to have the glycine dominate the other aminos, if that makes sense. So I’m taking more of it. I’m trying to minimize the other ones to some degree.
The glycine has tremendously helped me in a number of areas: improved sleep, improved mood, muscles, skin. It makes you kinda chill…at least it does for me.
I have the MTHFR mutation and Chris Masterjohn says it helps with methylation. That’s another reason I take it.
- An interesting side note: I don’t lift weights, but occasionally I will jump on my Total Gym and do a workout. As a result of taking the increased glycine, It appears that my muscles are more toned and firmer. Without much exercize.
Fyi, I don’t always take straight glycine- I use gelatin and collagen as well. I also don’t always get 20 gms. But I do aim for higher amounts. I mix it in my milk.
Thank you!!
- An interesting side note: I don’t lift weights, but occasionally I will jump on my Total Gym and do a workout. As a result of taking the increased glycine, It appears that my muscles are more toned and firmer. Without much exercize.
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Haa anybody tried sodium selenite and selenomethionine and can compare them ?
According to the study I posted sodium selenite should be quite a bit more effective than selenomethionine.
Dare to think.
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@Ecstatic_Hamster said in Methionine/Cysteine restriction increases longetivity AND energy expenditure:
@Amethyst said in Methionine/Cysteine restriction increases longetivity AND energy expenditure:
My goal has been to have the glycine dominate the other aminos, if that makes sense. So I’m taking more of it. I’m trying to minimize the other ones to some degree.
The glycine has tremendously helped me in a number of areas: improved sleep, improved mood, muscles, skin. It makes you kinda chill…at least it does for me.
I have the MTHFR mutation and Chris Masterjohn says it helps with methylation. That’s another reason I take it.
- An interesting side note: I don’t lift weights, but occasionally I will jump on my Total Gym and do a workout. As a result of taking the increased glycine, It appears that my muscles are more toned and firmer. Without much exercize.
Fyi, I don’t always take straight glycine- I use gelatin and collagen as well. I also don’t always get 20 gms. But I do aim for higher amounts. I mix it in my milk.
Thank you!!
My pleasure!
- An interesting side note: I don’t lift weights, but occasionally I will jump on my Total Gym and do a workout. As a result of taking the increased glycine, It appears that my muscles are more toned and firmer. Without much exercize.
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@Mauritio said in Methionine/Cysteine restriction increases longetivity AND energy expenditure:
Haa anybody tried sodium selenite and selenomethionine and can compare them ?
According to the study I posted sodium selenite should be quite a bit more effective than selenomethionine.
How about a Brazil nut. 1.2g PUFA but 90mcg of selenium elemental.
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@Ecstatic_Hamster I think it's mostly selenomethionine.
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@Mauritio said in Methionine/Cysteine restriction increases longetivity AND energy expenditure:
anybody tried sodium selenite and selenomethionine and can compare them ?
*) Forms of sélénium
The forms of selenium exist in 3 major forms:- Yeast
- Sodium (selenite or selenate)
- Amine acid (Selenio-Methionine or Cysteine).
Selenate or seleno-methionine (SM) are generally found on the market. Specialists classify the Se in two main categories: organic and inorganic. The inorganic salts would be supposed to be less well absorbed by the tissues. If we only refer to SM and Selenate, this is not really true, as several studies have shown it. (4)
*) Biodisponibility
The degree of absorption of selenite is less, but sufficient, of the order of +/ 50 to 60 % against 75 % for selenomethionine. (2)
What form is the best?
Selenium in any form whatsoever, that it comes from food or supplements, organic or inorganic, is used by the body for the synthesis of selenoproteins after being first metabolized in hydrogen selene, selenium cellular storage. The surplus of selenium is converted into methylated metabolites and excreted by urine and breath. Excessive accumulation of hydrogen selenial can cause its oxidation, resulting in the production of reactive oxygen species (ROS) resulting in oxidative toxic effects in the body. (o)
All forms of selenium are well absorbed, but the absorption of selenomethionine is the best. They use the same active transport mechanism as for methionine, one of the 9 essential amino acids which can only be obtained by food, which increases the effectiveness of absorption of selenomethionine compared to the inorganic forms of the selenium.
*) Recommended Daily Supply
Currently recommended nutritional supply (RDA) in adults is 55 micrograms/day. - Daily needs are 55 mcg (AJR). 1 mcg /kg of weight is optimal.
- Diet (1) provides around 50 % of needs if you eat meat or legumes. A single nut from Brazil / Amazon covers needs (…).
- In the event of pathology / detox, 200 - 300 mcg can be prescribed punctually.
- “Too Much of A Good Thing is Bad!”
=> Selenium supplementation should not be taken every day (half-life). Except in particular cases, in the event of a detox for example, therefore punctually (2 to 300 mcg per day, in detox cure). But in this case, a contribution of curcumin would be desirable to reduce hepatic toxicity due to the impact on dehydrogenase enzymes. - Taking different forms of selenium is interesting, especially in the event of cancer prevention (recurrence).
- If you exceed +/ 100 mcg/ L in the blood serum, you impact the operation of certain dehydrogenase enzymes, especially required in the Krebs cycle.
*) More details on this post, with sources and references.
Selenium: Too much of a good thing is bad. Forms and enzymes
https://mirzoune-ciboulette.forumactif.org/t1953-selenium-too-much-of-a-good-thing-is-bad#27971 (in French ) translator needed but with references from studies in English)
Sources et Références
0) Toxicité hépatique due à l’impact sur les enzymes déshydrogénases
Rôle protecteur de la curcumine
Protective effect of curcumin during selenium induced toxicity on dehydrogenases in hepatic tissue. 2005
PMID: 15881869
Selenium administration resulted in a marked decrease in the activity levels of the liver succinate dehydrogenase, malate dehydrogenase, and lactate dehydrogenase while pyruvate dehydrogenase increased significantly.
2) http://www.hc-sc.gc.ca/ewh-semt/pubs/water-eau/selenium/index-fra.php
Avec références d'études. -
A new study showing MR increases lean mass, CO2, energy expenditure and especially glucose oxidation.
"MR mice also have increased insulin sensitivity along with increasing indirect calorimetry markers such as energy expenditure, oxygen consumption, carbon dioxide production, and glucose oxidation."
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I've never thought of this but MR could be incorporated before and after scheduled stressful events, like surgeries. And it seems to be effective.
"Furthermore, we demonstrate the potential of short-term preoperative MetR as a simple intervention to ameliorate vascular remodeling after vascular surgery."
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@DavidPS lol no, all the "blue zones" are meat based diets. Check the video "blue zone lies".
https://www.youtube.com/live/QhQVETLSd2g?si=qBKgSPjAjU_UWUF_You can not live well without large enough quantities of the fat soluble vitamins from animal products.
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"SAH supplementation reduces Met levels and recapitulates many physiological and molecular effects of MetR."
https://pubmed.ncbi.nlm.nih.gov/35388610/ -
Another helpful supplement might be sarcosine. MR could lower its levels to begin with but on top of that it might be helpful to supplement it since it lowers methionine levels and shows some of the benefits of dietary restriction
"We also show that sarcosine feeding reduces Met levels in old animals and is a strong activator of macroautophagy in vitro and in vivo. Taken together, these data identify sarcosine as a potentially important biomarker of diet and aging in mammals and suggest that this metabolite plays a previously unappreciated role in mediating at least some of the beneficial effects attributed to DR on proteostasis."
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@Mauritio Sarcosine seems to be a mixed bag.
https://febs.onlinelibrary.wiley.com/doi/full/10.1002/1878-0261.12439
DNA hypermethylation is one of the most common epigenetic modifications in prostate cancer (PCa). Several studies have delineated sarcosine as a PCa oncometabolite that increases the migration of malignant prostate cells while decreasing their doubling time. Here, we show that incubation of prostate cells with sarcosine elicited the upregulation of sarcosine N-demethylation enzymes, sarcosine dehydrogenase and pipecolic acid oxidase. This process was accompanied by a considerable increase in the production of the major methyl-donor S-adenosylmethionine (SAMe), together with an elevation of cellular methylation potential. Global DNA methylation analyses revealed increases in methylated CpG islands in distinct prostate cell lines incubated with sarcosine, but not in cells of nonprostate origin. This phenomenon was further associated with marked upregulation of DNA methyltransferases (Dnmts). Epigenetic changes were recapitulated through blunting of Dnmts using the hypomethylating agent 5-azacytidine, which was able to inhibit sarcosine-induced migration of prostate cells. Moreover, spatial mapping revealed concomitant increases in sarcosine, SAMe and Dnmt1 in histologically confirmed malignant prostate tissue, but not in adjacent or nonmalignant tissue, which is in line with the obtained in vitro data. In summary, we show here for the first time that sarcosine acts as an epigenetic modifier of prostate cells and that this may contribute to its oncometabolic role.
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@Ecstatic_Hamster Im not sure about this one.. Here are 2 studies showing no or very little correlation to cancer. And even if they did, correlation ≠ causation. Sarcosine might be an endogenous anti-tumour factor and that could be the reason it' s high.it reduces methionine levels and strongly increases glycine's effects, both causes an anti-tumour effect. And i'm not sure these effects are taken into account in the in-vitro studies.
"Median sarcosine content in tissue was about 7% higher in matched malignant vs nonmalignant samples, which was significantly. Sarcosine values were not associated with tumor stage (pT2 vs pT3), tumor grade (Gleason score less than 7 vs 7 or greater) or biochemical recurrence. The lack of metastatic tissue samples was a study limitation."
https://pubmed.ncbi.nlm.nih.gov/21168877/Serum sarcosine is not a marker for prostate cancer
pubmed.ncbi.nlm.nih.gov/20233752/Here's a good explanation:
https://www.nature.com/articles/nrurol.2011.33 -
This study shows that sarcosine lowers brain serotonin, while increasing GABA.
I took 500mg today. It was quite nice. My mood increased and my muscles looked fuller , also my skin and hair looked better . As if I had taken a big dose of collagen.
So far so good. It wasn't too exciting but it also wasn't sedating so actually a nice balance."Pretreatment of sarcosine (600 mg/kg, i.p.) non-significantly improved learning and memory deficits induced by non-competitive NMDA receptor antagonist MK-801, significantly increased the GABA and decreased the 5-HT levels (p<0.05)."
https://pubmed.ncbi.nlm.nih.gov/25710578/
