Advice on lowering endotoxin

LucH

@Insomniac said in Advice on lowering endotoxin:

I've read soaking could help a little.

Yes, specially for almonds.

Insomniac

@Sugarnotsnow TexugoDoMel had a great post about oleic acid being useful to possibly induce efa if I recall.

I have mixed feeling about monos but the do seem to be less likely to increase endotoxin absorption from the gut than saturated fats.

LucH

@GreekDemiGod said in Advice on lowering endotoxin:

Shouldn’t the goal be not lowering endotoxin, but healing the gut lining, so that endotoxin doesn’t pass into circulation anymore?

Chatgpt sits besides.
Of course, gut lining must be fine. Need glutamine 1/4 tsp in a shake. 2x/d. Not if dysbiosis (candida albicans can feed with).
Edit: Chatgpt is right but only when taking a LPS killer, like EO or antibio. Not at the same time fat + killer. Not during 30' after ingesting food. Wait until food goes out of the stomach into the first part of the colon. See beneath (other post).
End of the edition.

LPS is going to overload the liver. It's going to turn around in the blood circulation if not neutralized or captured towards the feces. Not a good idea to wait to see if the immune system is going to react.

Serotoninskeptic

@Insomniac Do you have a link to the post? Sounds interesting

LucH

Haidut has posted about useful nutrients. Find back in my "wallet".
Vitamin A reduces the half-life of endotoxin by a half: Acute effects of vitamin A on the kinetics of endotoxin in conscious rabbits

Since B1 is required for cell fuel and brain function, Thiamine and magnesium should be taken to heal gut inflammation if you want some left for the brain.
Note: Not a B50 (an inadequate level of B1 taking every day could overexcite cell growth).

Vitamin B2 (riboflavin) Is Endotoxin (LPS / TLR4) Antagonist
https://raypeatforum.com/community/threads/vitamin-b2-riboflavin-is-endotoxin-lps-tlr4-antagonist.12061/
This is just a follow up on the recent post on both riboflavin and vitamin D.
Vitamin B2 Remarkably Effective Against Endotoxin, Sepsis, And Other Bacterial Infections
https://raypeatforum.com/community/...gonist-may-treat-lps-linked-conditions.12060/

Endotoxin (TLR4) antagonists are very beneficial substances and the more we have in our arsenal the more opportunity for successfully treating inflammation-related conditions.

Immunomodulatory effect of riboflavin deficiency and enrichment - reversible pathological response versus silencing of inflammatory activation. - PubMed - NCBI
http://www.ncbi.nlm.nih.gov/pubmed/26769828

LucH

@Insomniac said in Advice on lowering endotoxin:

I have mixed feeling about monos but they do seem to be less likely to increase endotoxin absorption from the gut than saturated fats.

I haven't the same analyze. Partly true however if ... See details beneath.
How to manage with LPS endotoxins
Cascara tea + carrot salad with organic cider vinegar and 1 tbsp of olive oil. The Cascara if you have transit problems. Otherwise, carrot salad alone is sufficient.
Process: Cascara sagrada is mainly used to treat constipation. The anthraquinones contained in the bark inhibit the absorption of water and electrolytes in the intestines. As a result, the volume of the stool increases as it absorbs excess water, which increases the pressure in the intestine. This stimulates muscle contractions in the colon (peristalsis), which speeds up emptying of the intestine.

To what extent are these elements relevant to facilitating the elimination of LPS endotoxins after taking antibiotics or chemotherapy?

Glycine (homemade bone broth): Glycine attenuates the increase in LPS caused by the concentration of intracellular Ca and moderates TNF-Alpha in liver kupffer cells (glycine-gated chloride channel).
Vitamin E (mix tocotrienols and tocopherols)
Source: Attenuation of lipopolysaccharide (LPS)-induced cytotoxicity by tocopherols and tocotrienols. Keiko Nishio et al. Redox Biol. 2013
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3016328/
Vitamin D is an antagonist of endotoxins (LPS / TLR4)
The expression of TLR4, NF-κB, and TNF-α was downregulated by 1,25(OH)2D3 in a dose-dependent manner.
Source : https://raypeatforum.com/community/threads/vitamin-d-is-endotoxin-lps-tlr4-antagonist-may-treat-lps-linked-conditions.12060/
Orange juice: 100 ml of fresh orange juice at breakfast. => Interesting contribution of Ca and Mg and vitamin C.
Source:
Orange juice neutralizes the proinflammatory effect of a high-fat, high-carbohydrate meal and prevents endotoxin increase and Toll-like receptor expression.Orange juice neutralizes the proinflammatory effect of a high-fat, high-carbohydrate meal and prevents endotoxin increase and Toll-like receptor expression.
Supply of fatty acids to carry endotoxins
Sources:
Effect of Dietary Lipids on Endotoxemia Influences Postprandial Inflammatory Response. Journal of Agricultural and Food Chemistry, 65(35), 7756–7763 |
https://pubs.acs.org/doi/abs/10.1021/acs.jafc.7b01909
Effets protecteurs du cholestérol sur les endotoxines
Note: Increased production of LPS residue after taking antibiotics or Phage Complete.

Avoid eating fatty foods during the attack phase.

A diet high in fat can make it easier for LPS to pass through the intestinal wall. Certain fatty acids actually serve as conveyors, especially the most unsaturated ones. In the event of a significant die-off, it will be advisable to take the antibiotic (or another viricidal substance) away from the meal. Therefore an inter-digestive intake is recommended.

Insomniac

@Sugarnotsnow I think it was this one.
https://bioenergetic.forum/topic/2010/mead-acid-desaturases-and-accelerating-pufa-efa-depletion/2?_=1727467751483

Insomniac

@LucH I believe I was recalling this study regarding lps being absorbed better with saturated fats but I've seen a few over the years.

https://ajcn.nutrition.org/article/S0002-9165(22)01122-4/fulltext

Discussion
This double-blind, randomized crossover trial demonstrated that a single meal high in saturated fat can impede attention—resulting in reduced detectability—compared with an identical meal high in monounsaturated fat. Importantly, each woman consumed both meals, and thus between-person biological or genetic variability did not account for the observed meal effect. Endotoxemia played a role as well, as women with elevated endotoxemia markers had poorer attention across CPT testing occasions. As the gastrointestinal tract is the primary source of endotoxin (7), these results implicate bacterial endotoxin translocation from the gut to the bloodstream (“leaky gut”) in sustained attention deficits similar to prior findings (5, 28–31).
The interaction between endotoxemia and experimental meal type was especially noteworthy: a single high-saturated-fat meal caused relatively poorer postmeal cognitive performance only in the context of low endotoxemia. That is, endotoxemia erased between-meal differences, impairing postmeal attention regardless of meal type. Notably, participants who were 1–2 SDs above the means for endotoxemia markers approached clinically significant t-score values (>60), indicating possible cognitive impairment. Although a single meal high in saturated fat did not induce clinically significant levels of cognitive impairment, repeated exposure to high-saturated-fat intake may do so.

LucH

@Insomniac said in Advice on lowering endotoxin:

This double-blind, randomized crossover trial demonstrated that a single meal high in saturated fat can impede attention

Attention: The conclusion is different from facts.
Excerpt:
In adjusted models, women had more difficulty distinguishing target stimuli from distractors after consuming the high-saturated-fat meal than they did after the oleic-sunflower-oil meal (B = 4.44, SE = 1.88, P = 0.02).
Context:
Endotoxemy is present before ingesting 2 kinds of fats.
My reading:
The end-conclusion of the study is not the same as the elements of the study:
The study says:
Saturated-fat intake individually and jointly [negatively] influence attention [among the sujects].
My comment:
In terms of conveyor, SFA is very poor. The level of capacity to carry away is proportionally higher when the fat is unsaturated.
=> If you want a transporter take oleic sunflower. Mind this point: oleic sunflower is 85 % MUFA and is poor in PUFA. Not the same kind as usual sunflower oil. Not all oleic sunflower oils have the same compo.
Note: The take away would have been still more important with omega-3. Not necessary but this is relevant in the event of a crisis. Good to know.

Insomniac

@LucH I'm sorry, this was the study that I recalled for anyone interested.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3577458/

Results

Postprandial serum endotoxin concentrations were increased after a meal rich in saturated fatty acids and decreased with higher n-3 PUFA intake. Compared to the no oil control, fish oil and CLO which are rich in n-3 fatty acids reduced ex vivo endotoxin Papp by 50% (P < 0.05). Contrarily, saturated fatty acids increased the Papp by 60% (P = 0.008). Olive and vegetable oils did not alter intestinal endotoxin Papp.

Insomniac

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Insomniac

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