Glycine + N-Acetylcysteine increases lifespan by ~25%.
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As precursors to the master antioxidant glutathione, this combination reduces organ damage and preserves mitochondrial function even at low amounts.
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this was a good study at Baylor. But a small one. It calls into question the idea that cysteine is bad. Maybe it's not so bad.
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@Ecstatic_Hamster I think out of the "inflammatory" aminos cysteine is definitely the least problematic. Methionine and tryptophan cause more issues
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@Ecstatic_Hamster @Serotoninskeptic
Eating gelatin regularly, which contains glycine, I am not sure if eating regular meat is good enough for my body to produce glutathione but that's what I've been doing.
As meat already contains a smattering of cysteine and l-glutamate which with glycine can be made into glutathione. Not that it doesn't contain methionine and tryptophan.
Have thought about taking NAC, but I have this feeling I am already covered and I don't really have to take NAC if I don't have to.
What are your thoughts?
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There are products available that contain this combination, and I've seen one that adds proline. I've made my own version of this, but the glycine always ends up wiping me out. And the general consensus about NAC has me hesitant to pursue it any further.
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@Mossy Do you have a link to the products you are referencing?
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The following link is a repost but it's a good fit here:
Be sure to check out the secondary link posted right above the sample table, it leads to a database of anti-aging substances along with an estimation of their total benefit. I found Thymic peptide (Thymus gland), Vanadyl Sulfate (Vanadium) and a few others interesting, along with Aspirin of course.
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@BioEclectic Thank you
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@Serotoninskeptic said in Glycine + N-Acetylcysteine increases lifespan by ~25%.:
@Mossy Do you have a link to the products you are referencing?
I searched for the one with proline but couldn't find it. Here is one with the glycine and NAC:
https://www.amazon.com/Pure-Encapsulations-NAC-Glycine-Powder/dp/B08WJDLHMJ
I'll continue to look for the one with proline.
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@Mossy Nice thank you
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"Enhanced cysteine transport and its metabolism enable cancer cells to adapt to a challenging tumor microenvironment and acquire chemoresistance. This section discusses the role of cellular signaling molecules and proteins in regulating cysteine metabolism in cancer development and drug resistance."
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9893486/"NAC may also accelerate the progression of some cancer growth."
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9563555/Haidut also speaks against NAC - can't find a specific podcast now; it was one done with Strong Sistas.
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I second the caution against cysteine supplementation .
There was a study that showed the same life extension from just using glycine. HED was 50g. So cysteine is not necessary.
If you want to increase glutathione you could simply take ergothioneine which increase it drastically and also increase life span by about 25%.
If you want to increase antioxidants generally, you could take selenium or selegiline which have strong anti-oxidant capacity. Selegiline also increases life span by about 25% .
And remember adding just 0.2% cysteine to the diet, abolishes the benefits of methionine restriction. So it is by no means harmless. Especially since methionine can be converted to cysteine so it's almost impossible to be deficient in it.