My wild IdeaLabs nail test results - opinions ?

Mauritio

I didn't take any hormones or hormonal precursors.
Any comments, thoughts or recommendations?

Some values are absolutely off the charts high, some are normal.

Skyhigh:

DHT: 441; more than 20x the upper limit of the idealabs range
Androsterone:436; 10-15x above the upper limit
DHEA-S: 50; 5-10x the upper limit

Others:
Testosterone: high (but the normal and and the idealabs reference values vary quite a lot)
Androstenedione: high
Estrogen: low to-medium
Cortisol: medium
Cortisone: low
DHEA: low
Some values are below detection: pregnenolone, progesterone and some others ...

Mauritio

Interpretation:

The ratios on the second page are quite useful:

Cortisol/DHEA ratio:
Optimal: 0.3-0.5; Chronic stress>0.5 ; mine: 0.08
--> not sure why a lower than optimal cortisol/DHEA ratio isn't better, since it indicates lower stress/higher youth steroids
Cortisol/Cortisone:
more than 1= chronic stress; mine= 1.3
--> chronically stressed? Not sure, who isn't ?! Although in this case it isn't that my cortisol is extremely high, but that my cortisone is pretty low, increasing the ratio
DHT/Testosterone:
0.2=optimal, if > 2 then may suggest hyperandrogenemia and/or supplementation with DHT or another structurally similar steroid.
Mine=94
--> hyperandrogenemia, so above 2 is high and mine is 94. Its not that T is low, but DHT is just really high.
Androstenedione/DHEA:
If lower than 1.5 it might indicate a 3bHSD deficiency; mine: 0.35
--> this one I don't get, 3bHSD converts DHEA to androstenedione, so if it's low as in my case, this should mean high DHEA and low androstenedione, yet the opposite is the case for me...

5.Androgen/Estrogen
Above 50 is estrogen dominance, mine= 0.99
--> Again, very high androgens, low-mid estrogen

6.Cortisol/Testosterone
Lower than 10 is optimal
Mine= 1

DavidPS

@Mauritio said in My wild IdeaLabs nail test results - opinions ?:

I didn't take any hormones or hormonal precursors.

Could it possibly be related to taking rapamycin?

Mauritio

@DavidPS said in My wild IdeaLabs nail test results - opinions ?:

@Mauritio said in My wild IdeaLabs nail test results - opinions ?:

I didn't take any hormones or hormonal precursors.

Could it possibly be related to taking rapamycin?

I thought about that too, but I don't think so, the amount I took was too low.

I took 1mg twice in the three months period that the nails cover. That's very little. So most of the time I had no detectable levels of rapamycin in my body.

I was thinking maybe adrenal over activity. But for that to be the case cortisol and cortisone are too low. Aldosterone I'm not sure about the range ...

DavidPS

@Mauritio - Thanks for the explanation. These hormones are too complex for me. I am concerned about the low level of your youth promoting hormones.

Mauritio

@DavidPS
Me too. But I have high androgens so maybe there's a lot of downstream conversion , so there's less precursors available.

I wish there were more people doing these tests so we can compare them.

did you do nail or hair?

Mauritio

@sneedful nail

evan.hinkle

@Mauritio this is the very reason why I haven’t pulled the trigger yet on this test, (“wish more people were doing them”). Georgi understandably cannot comment, and many of the ratio indicators just aren’t followed by your average doctor. Heck, if you show the average doctor low cortisol like yours they’ll probably set you up for shots of cortisone, lol…

what if the hormone oxidizes or something in nail or hair when exposed to light

Mauritio

@evan-hinkle yeah that's why I'm looking for a Peaty practitioner to give me a quick analysis for this, preferably without having to pay 500€ for it...

Mauritio

I've contacted IdeaLabs regarding there being a measurement error:

"It is not an error. We actually run 3 independent tests on each sample to weed out outliers and then average the results. The high DHT and androsterone make sense considering their precursors DHEA-S is 10x the upper limit of the range. It may be worth doing some blood work for those that are very high and see what the doctor has to say about it if they come back high again.
The tests you have seen from bodybuilders are most likely either in blood or urine and those are not reliable as they do not reflect cellular levels. Cells often accumulate steroids in concentrations up to 100 times higher (e.g. DHEA) than what is present in blood and the hair test is a good surrogate for tissue levels.
http://haidut.me/?p=2104"