Low dose naltrexone

Serotoninskeptic

Has anynody tried low dose naltrexone? Ive heard from @anabology its beneficial for gut issues. It blocks TLR4 and prevents the endotoxin-mediated inflammatory cascade. It also is said to improves energy and mental clarity. He recommends starting with 1.5mg, and increasing to 4.5mg. Any experiences eith this protocol?

Other potential issues which can be resolved with naltrexone:

Migraines
Chronic fatigue
Fibromyalgia
Multiple sclerosis
Psoriasis
Autoimmune conditions
Leaky gut
Depression
Anxiety
Aging
Atherosclerosis

Anakin

I guess antiopioids arent good 4 teeth

josh

I used it for about a year gradually making my way up to 4.5 mg. It did increase my feeling of dopamine, but You do need to grade up to 4.5 mg slowly.

I was told at the time that it worked by briefly blocking your dopamine receptors causing them to overcompensate with more dopamine. If you take too large a dose straight Away your dopamine receptors will be unable to respond adequately to the stimulus.

A really good resource with many Interviews of people who have taken LDN for different conditions is the:
https://ldnresearchtrust.org/

Ultimately I stopped the LDN because I didn’t want to be on it for too long a time and I wanted to know how I felt without it. One of the good things about LDN You can stop it Cold turkey without having any withdrawal symptoms because your dopamine levels remain at a higher level post usage.

Sorry, I am unfamiliar with the use of LDN to reduce endotoxin, but it would make sense With its anti-biotic properties.

Serotoninskeptic

@josh Thank you for sharing your experience! Very imformative

thyroidchor27

will try soon. Travis was convinced mu opiod receptor desensitisation is why cow milk and bread (gluten) had to be avoided

the_black_jew

@thyroidchor27 be careful following too many opinions of a stupid smart guy. better to take advice from smart stupid guys, imo.

CrumblingCookie

@Serotoninskeptic said in Low dose naltrexone:

He recommends starting with 1.5mg, and increasing to 4.5mg. Any experiences eith this protocol?

I've felt mild benefits, as in a tiny bit more stable physically and mentally from 4mg naltrexone daily. I felt like the 4mg were too much. Ultimately it wasn't worth continueing for me after I had used it up.
Also, if I were to give it another try I'd argue against increased doses but instead go for 1mg or even less. As in ULDN (ultra low dose naltrexone).
The way it's reported to act through the opiod recepters in incrementally smaller doses is funnily kind of reminiscient of homeopathy.