The pro-metabolic effects of ultrasound
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Peat rarely talked about ultrasound, but I suspect it can help metabolism by increasing local tissue heat and thereby mimicking a healthy metabolism for a while. There are also heat-independant effects, possibly through structuring the cellular water a la Gilbert Ling.
We're going dark Peat right away. But bear with me.
1.Ultrasound on balls.
This is only in vitro. But very impressive.
Ultrasound Increases Testosterone production in leydig cells by up to 80% .
Doubled StAR, the rate limiting enzyme for steroid production .
https://pubmed.ncbi.nlm.nih.gov/36613865/
Here's a rodent study showing 20 min/day for 7 days increased testosterone by 62%
1.5-MHz frequency, 1-KHz repetition pulse rate, 200-microseconds pulse width, 30-V peak-to-peak amplitude and 20-mW/cm2 intensity) applied to the skin for 20 min/day for 7 days
https://pubmed.ncbi.nlm.nih.gov/1823286/Someone filed a patent for using ultrasound for testosterone enhancement in humans. Including protocols and safe dosages.
https://patents.google.com/patent/WO2022026607A1/en?oq=WO2022026607A12.Anti-septic (200 mW/cm2, 0.37 MHz, 20% duty cycle and 20 min)
They induced sepsis in mice.
After 5 days all of the mice were dead.In the sepsis + ultrasound group half of the mice were still alive after 5 days. Not only that, they seemed to recover from sepsis and were still alive after 40 days!
https://www.umbjournal.org/article/S0301-5629(23)00093-5/fulltext3.Ultrasound increases topical absorptionof substances.
Aspirins absorption was enhanced by a factor of 300 ! Topical aspirin anyone ?
Ultrasound also enhanced steroid absorption. I'm thinking Idealabs + ultrasound.
This might be useful for topical hair loss formulas like as well, since absorption can be an issue here.
https://pubmed.ncbi.nlm.nih.gov/8692734/4.Other:
Ultrasound helps with Inflammatory bowel disease.
https://www.researchgate.net/publication/348880743_Non-invasive_peripheral_focused_ultrasound_neuromodulation_of_the_celiac_plexus_ameliorates_symptoms_in_a_rat_model_of_inflammatory_bowel_diseaseHelps with osteoarthritis.
"Long-duration low-intensity ultrasound significantly reduced pain and improved joint function in patients with moderate to severe osteoarthritis knee pain."
https://pubmed.ncbi.nlm.nih.gov/30326947/"Scientific evidence supports the use of LITUS to treat soft tissue injuries, and improve outcomes for musculoskeletal injuries and post-operative recovery."
https://pubmed.ncbi.nlm.nih.gov/30198009/Dare to think.
My X:
x.com/Metabolicmonstr -
At home devices are available in the price range of 50-200$/€
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@Mauritio Really interested in portable ultrasound devices for bone growth. I bet ultrasound + topical Kuinone could do wonders for a jawline.
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@serotoninskeptic - Dr. Peat advised not to use ultrasound around the head, as it can potentially emulsify brain tissue if too energetic.
Yeah, I knew someone who had extreme breast pain premenstrually, and she found that a quick application of ultrasound relieved it completely. And it's been known for quite a while that any injured tissue repairs itself faster under the influence of mild ultrasound. Bone injury heals faster, and I'm sure that would apply to tendon and ligament injury too. But you want to keep it away from your head. I don't think it's good to risk brain emulsification by too much ultrasound.
“Medical science has made such tremendous progress that there is hardly a healthy human left.”
Aldous Huxley 👀
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@serotoninskeptic yeah the ultrasound helps with bine growth AND vitamin K absorption so should be a good combo for fractures and so on .
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@DavidPS thanks for sharing.
This women has spectacular results by applying it her head. -
I have ordered a device already.
And I'll probably first try over liver or gut.
Maybe later thyroid or testicles.Dare to think.
My X:
x.com/Metabolicmonstr -
@Mauritio the tooth fairy aint gonna see this coming
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@lobotomize-me it's in the name of science ..it's ok .
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@Mauritio - Dr. Peat has a positive story about using ultrasound over the liver.
it would be a good change of technology to use to switch over to ultrasound. A friend of mine who was for a year or more had had liver enzyme elevation and signs of hepatitis or developing cirrhosis had a very prolonged ultrasound examination of her liver and a couple of weeks later went back for another exam and her liver had completely recovered. I suspect it was from that very half an hour or so of looking around with an ultrasound imaging device.
“Medical science has made such tremendous progress that there is hardly a healthy human left.”
Aldous Huxley 👀
☂️ -
I had ultrasound long ago when I had knee surgery, (I don’t ever have knee problems anymore). I’m following this thread with great interest. Anyone find any info on ultrasound for the thyroid? I seem to remember an old study @haidut posted on the old forum about heat alone regressing tumors…
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@Mauritio Let us know how it goes
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@DavidPS Thanks!! Super cool. will try it out over the liver/ gallbladder.
I sometimes have cholestasis-like issues and hope it will help.
This study looks promising. It seems to help short term and long term with gallbladder contractility.
"LIPUS treatment obviously enhanced gallbladder contractility in response to CCK-8 stimulation and accelerated bile crystal clearance. It also reduced inflammatory cell infiltration and tissue edema, and promoted new capillary formation in the gallbladder, mitigating the progression of CGS. Furthermore, LIPUS restored CCKAR expression and improved the thickness of the gallbladder smooth muscle layer, providing a structural basis for increased smooth muscle contractility."
SETTING:
Intensity: 800 mW/cm²
Frequency: 3 MHz
Duty Cycle: 30% -
@evan-hinkle i think I saw a study successfully using high frequency ultrasound for thyroid nodules , but can't find it right now.
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Peat mentioned 50-100 000 Hz as an effective healing frequency.
They noticed that it would heal infected tonsils as well.
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It seems to generate more mitochondria in muscles . Which makes me wonder if it helps with exercise recovery and muscle growth ?!
"We conclude that absolute increases in UCP-3 protein content in the early adaptive phase were associated with the genesis of mitochondria containing a normal complement of UCP-3. "
https://pubmed.ncbi.nlm.nih.gov/15308491/ -
Ultrasound has an anti-catabolic effect in this study inhibiting myostatin.
https://pmc.ncbi.nlm.nih.gov/articles/PMC8625684/"LIPUS promotes exercise-induced muscle hypertrophy by facilitating protein synthesis and inhibiting the protein catabolism pathway."
https://pubmed.ncbi.nlm.nih.gov/28461063/Low-intensity pulsed ultrasound prevents muscle atrophy induced by type 1 diabetes in rats
https://pubmed.ncbi.nlm.nih.gov/29273088/Ultrasound Modulates the Inflammatory Response and Promotes Muscle Regeneration in Injured Muscles
https://link.springer.com/article/10.1007/s10439-013-0757-y -
@Mauritio may we ask what calibre that device is and why you chose that particular measure?
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@16charactersitis Sure. I tried getting the one that the women on X was using, but it costs 100€ shipping to germany. So I bought this one, which is probably slightly more powerful and a bit more pricey.
It has 3 different Intensity settings:
80mW/cm2 (low)
800mW/cm2 (middle)
1600mW/cm2 (high)It uses 1 MHz.
To replicate most studies the lowest setting will suffice. They mostly use 20-80mw/cm2. But for example the gallbladder study used 800mW/cm2 so the second setting works perfectly for that.
I mentioned the respective ultrasound settings they used in most studies or you can see them in the images.https://www.tensshop.de/Ultraschall-Therapiegeraete/Ultraschall-Therapiegeraet.html
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@Mauritio
I'll follow this thread and your experiences with using your US device.
Something in me says that all this can't be right in general, although I know that US devices are even regularly being used on muscles and ligaments in physiotherapy. I find all US applications hugely uncomfortable and these feelings of something disturbed in my tissues lasts for days.
The adequate selection of applied frequencies (or even their pulse pattern wrt to peaks and sharpness at the edges, ie the device's hardware) could play out to be crucial. In contrast to simply "blasting ultrasound energy" into tisssues.
I find the graph of the first posting above unconvincing or at least inconclusive, not least because of the short time period of observation as I remember studies which very clearly found that long enough ultrasonography (only 5-15 minutes iirc) on the testicles leads to infertility for about 1/2 year due to profoundly impaired spermatogenesis.I would suspect the benefits may be similar or downright due to the concept of mitohormesis. I.e. the US puts stress into cells and tissues whereupon - if not overdone - the body overcompensates by becoming more resilient to "proper" stressors.
In which case the adequate dose in mW/cm² would be strongly dependent on the individual, overall physiological condition and the bodily reserves which can be activated and mobilized to support such overcompensation and anabolism.
