The funniest/most charming guy i ever seen is on SSRIs
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SSRIs have a side effect which is to increase neurogenesis and it usually takes a while for this to happen, they attribute the positive effects to serotonin but it is probably neurogenesis that is responsible, over time I believe that the consequences outweigh the benefits and we already know what happens to most. The response is individual, some take longer and others sooner.
LSD, DMT, psilocybin, etc., basically work in the same way involving BDNF and TrKB receptors, and if used correctly should probably have far fewer side-effects. The “childlike playfulness” sometimes attributed to serotonin is actually the result of neurogenesis, in my opinion.
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Different SSRIs can act in different ways, and the effects vary person to person. Half the time they don’t work. Sometimes it ends up actually lowering serotonin. Sometimes it just cranks their cortisol which could actually make them feel good at first. The high serotonin can also increase allopregnanolone which is neuroprotective and give you that can’t be bothered feeling. I felt that when I smoked a ton of weed regularly.
The boost in allopregnanolone is probably a defense mechanism to deal with large amounts of brain serotonin though, not like a healthy thing
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@lobotomize-me I’ve been on ssris and they make you not want to talk to people I also suffer with PSSD now. Would not recommend.
No drug wil really cure your social anxiety the only way through social anxiety is to feel the fear and go through it. No pill no supplement no vitamin will cure your soul -
@gg12 >no drug will cure social anxiety
I mean if having a good metabolism through the use of something like t3 or etc is a drug then your statement is completely wrong
someone with a good metabolism and if that is caused from aspirin or t3 or something is way less likely to have social anxiety
the idea that some sorts of therapies are required like psychologist or some sort of mental technique is -- the latter is closer to the truth than former because good energy allows good mental techniques much easier. the former is useless past the basics without good metabolic tendencies
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@lobotomize-me OP I watched some more clips of that guy and the fact you look up to that behavior is funny and in line with your previous neuroses postings where you list 100 supplements and activities you do to optimize
nothing ive seen from him is legitimately funny, it's "funny" sure and I guess everyone has different tastes in entertainment and comedy, there is important information in how he looks and how he behaves. his eyes betray a sadness even though he is being "energetic" and outgoing. I know a guy who became a drug addict who looked just like him including the sad / empty look in his eyes
https://www.tiktok.com/@zachjustice/video/7486033591256878379
look at that clip. do you really find that funny?
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@eduardo-crispino It makes sense that he has some clips where he’s just downright babbling no one can be constantly upbeat and funny 24/7. Even the happiest/most energetic people, when forced in long conversations where they’re carrying the weight of it, experience short drops in brain activity. That can lead them to either say something they think is funny (but isn’t) or fall silent for a few seconds.
I believe the manner I started this thread was incorrect, because I am not here to discuss him. Rather I wanted to discuss the potential of SSRIs beyond raising serotonin (which we acknowledge is mostly harmful)
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@lobotomize-me he may be entertaining to some, but the feeling I get from watching him is that he's unwell. And that is throughout his videos, not just an isolated case.
I wanted to discuss the potential of SSRIs beyond raising serotonin (which we acknowledge is mostly harmful)
I've read fluoxetine can increase allopregnanolone in doses lower than needed for significant serotonin reuptake inhibiton, so maybe that could work. But I have no experience with it and don't know of it's safety.
Some things can give a net benefit despite also acting as an SRI, but I doubt it's worth exploring usual SSRI medications. But if you come across something that seems beneficial but is also an SRI, you might not want to dismiss it right away. Just be careful.
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@gg12 said in The funniest/most charming guy i ever seen is on SSRIs:
No drug wil really cure your social anxiety the only way through social anxiety is to feel the fear and go through it. No pill no supplement no vitamin will cure your soul
@gg12 said in Passionflower and OCD: personal experiences:
I honestly have stopped taking anything for my ocd. I just need to learn to accept my thoughts as thoughts... It is brutal but I cant use a life long crutch I hae to face my demons so I can stop being controlled by fear and accept uncertainty.
While I do think this kind of mentality is better than giving up or delegating all of your health decisions to a "professional", it's still very limiting. There's research on various substances showing that they can help with anxiety. Here's just one:
Even if you don't want to depend on an external aid, temporary usage can still assist in making long-lasting changes. We can use OCD as an example.
The usual therapy for OCD is exposure and response prevention (ERP) where the patient is exposed to things that trigger OCD, and they are supposed to avoid responding to this. But if a person experiences immense anxiety from not doing the OCD ritual, it can be very difficult, possibly impossible. Additionally, mental stress itself is harmful to health. If the patient is given something that reduces their anxiety, they might be able to progress through the therapy easier, faster and with less stress. And that being said...
@NoeticJuice said in Kanna (Sceletium tortuosum) eliminated OCD:
15 days since my last dose of kanna and my OCD is still only around 1% of what it used to be at it's worst
When I took it, I took it with the intention to free myself of OCD. When I noticed that I finally had the chance to choose differently, I had the determination to break the loop. Make of this what you will.
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@NoeticJuice Yo I actually really like that idea. Also bro where can I get kanna also Im gonna try taking NAC
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@gg12 said in The funniest/most charming guy i ever seen is on SSRIs:
where can I get kanna
Vendor List from r/Kanna
I only have experience with two different extracts, both from BioExtracts. One of them is Classic Sceletium Extract and the other one is FS5.
I tried Classic Sceletium Extract first and it was not effective for my OCD. I tried FS5 a few days later and it was very effective. Not all kanna is the same. Below is their alkaloid contents for comparison.
Classic Sceletium Extract has a total alkaloid content of 6%, out of which:
- 60% is mesembrine
- 20% is mesembrenone
- 20% is delta-7-mesembrenone
FS5 has a total alkaloid content of 5%, out of which:
- 25% is mesembrine
- 40% is mesembrenone
- 20% is delta-7-mesembrenone
- 15% are other alkaloids
I recommend reading more about kanna, including people's experiences with it, before trying it. But keep in mind that, based on what I've read, it seems like most people are using higher mesembrine extracts and using it for recreational, rather than therapeutic, effects.
You can find some general info about kanna from here:
- FAQ, dosages and general information
- All You Need to Know About Kanna's Pharmacology
- All You Need to Know About the Risks, Withdrawals, and Safety of Kanna
The linked posts may have some inaccuracies, but it's good enough for practical purposes.
The link below is possibly relevant to mesembrenone specifically, and the main reason why I decided to try kanna in the first place, but it's not important for the practical use of it, neither is it really even about it. Read it if interested, skip it otherwise.
You can read about my experience with kanna here:
I'm wary of using it daily since it does contain alkaloids that inhibit serotonin reuptake, but I might try it some time in the future just as an experiment. After some experimentation, I now use it once every 3 days.
@gg12 said in The funniest/most charming guy i ever seen is on SSRIs:
also Im gonna try taking NAC
If you're going to try both, I recommed trying one first for a period of time, then trying the other. This way you can develop a feel for the supplements, both for their potential positives and negatives.
I hope this helps.
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5-HT is the scientific name for serotonin.
5-HT1A is one of the receptors for Serotonin in the brain.
Lexapro downregulates the 5-HT1A receptor, e.g. makes it less likely to activate.
That ironically means Lexapro is an Serotonin Antagonist.So it increases Serotonin, but at the same time makes you somewhat immune to the effects of Serotonin. What you are seeing is the effect of a Antiserotonic Drug that is at the same time also an SSRI.
You might get a similar effect from Progesterone or oral GABA, without risking your health from the reuptake inhibition.
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Idk. I had a cousin who was smart, entertaining and someone people would envy. Then he committed suicide. One of those people that you are baffled by the news and can't understand it.
It's not the first time that I have had this experience in my life. One of my highschool friends also suicided on the night of the graduation. It was a very popular and as it seemed balanced guy with a great future ahead, so we thought.
How people portray themselves to the outside world has nothing to do with how they really are inside. Some people have become very good at fooling everyone around them. -
Sad.
@happyhanneke said in The funniest/most charming guy i ever seen is on SSRIs:
Some people have become very good at fooling everyone around them.
I think this can also happen internally.
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@pittybitty said in The funniest/most charming guy i ever seen is on SSRIs:
Lexapro downregulates the 5-HT1A receptor, e.g. makes it less likely to activate.
That ironically means Lexapro is an Serotonin Antagonist.There are presynaptic and postsynaptic 5-HT1A receptors. The presynaptic receptor is an autoreceptor. Desensitizing it leads to increased serotonin levels.
Lexapro and other SSRIs elevate serotonin levels and keep them elevated. Over time, this will desensitize the autoreceptor but not the postsynaptic receptor, at least not to the same extent. This leads to increased postsynaptic 5-HT1A activation.
Among other effects, the activation of the 5-HT1A postsynaptic receptor increases dopamine, oxytocin and neurogenesis. But SSRIs are a "dirty" way of achieving these effects. That is because they increases serotonin overall, and the activation of other serotonin receptors can counter the anxiolytic and anti-depressive effects of postsynaptic 5-HT1A activation. Additionally, it takes time for the autoreceptors to desensitize.
If I wanted to activate 5-HT1A, I'd probably just use a 5-HT1A agonist. The effects come quicker without an overall increase in serotonin.
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@NoeticJuice any recommendations?
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I've seen shorts of this guy and I immediately had the feeling that he was serotonergic and toxic. There's something off about him and the Lexapro might be part of it.
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@lobotomize-me Recommendations for 5-HT1A agonists? The only three that immediately come to mind that might have this effect are Albizia julibrissin, ginger and nuciferine (see this about blue lotus), though it seems like ginger contains partial agonists rather than full agonists. But ginger and nuciferine, probably also albizia, have other effects too.
- Antidepressant-like effects of Albizzia julibrissin in mice: Involvement of the 5-HT1A receptor system
- Identification of serotonin 5-HT1A receptor partial agonists in ginger
- In Vitro and In Vivo Characterization of the Alkaloid Nuciferine
I don't know if they activate the postsynaptic or presynaptic receptors. Activating both would probably be ideal for acute anxiolytic and anti-depressive effects. Idk about long-term (possible autoreceptor desensitization).
I tried albizia from Barlowe's last summer but didn't notice anything from it. But it's common for me to not respond to supplements. Some other people seem to like it, and it's know as "the happiness tree".
There might be some pharmaceutical or research chemicals with greater selectivity and potency but I don't know anything about those things in general.
5-HT1A does more than just increase dopamine and neurogenesis. Other effects include inhibition of erection, reduced appetite and increased heat dissipation. Depending on a person's context, they may or may not want to increase 5-HT1A activation. You can read more about 5-HT1A on wikipedia: 5-HT1A receptor
If you just want to increase dopamine and neurogenesis, some other things could help. The first two things that come to mind are aspirin and cistanche.
- Aspirin is a nootropic
- Cistanche tubulosa Protects Dopaminergic Neurons through Regulation of Apoptosis and Glial Cell-Derived Neurotrophic Factor: in vivo and in vitro
- Cistanches Herba enhances learning and memory by inducing nerve growth factor
But more than the supplements I listed, reading this might help you:
- "The Master and His Emissary: The Divided Brain and the Making of the Western World" (expanded edition) by Iain McGilchrist
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@NoeticJuice amazing stuff I was thinking about buying cistanche in the future but i habe looked up the prices in Europe and they seem to be awkwardly high
I will look into it again later
