Twitter fad fixating on Deuterium and carb seasonality? What's the deal?
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@eduardo-crispino said in Twitter fad fixating on Deuterium and carb seasonality? What's the deal?:
the other poster mentioned fish oil to compare it to the fish oil marketing scam and I don't think that's fair considering deuterium depleted water has potential health benefits that haven't been thoughtfully refuted like they have for fish oil
I'm just saying that his argument (or a part of it) is probably based on false premises and that you are confirming it without seemingly solid knowledge of the production processes.
My opinion:
- I think DDW can be useful for some diseases (cancer especially),
- Deuterium is considered bad for the production of energy but it can also be useful for other biological processes (collagen/bone production),
- accumulation of deuterium, or bad "fractionation", has probably deeper root causes than consumption of deuterium itself.
An interesting hypothesis:
The amino acid proline has unique properties that make it ideal for trapping deuterium, and we argue that peptidyl prolyl isomerases facilitate deuterium trapping in proline residues of proline-rich proteins, which are especially common as structural proteins in the extracellular space. The endothelial glycocalyx supports deuterium trapping in the gelled water maintained by the highly sulfated heparan sulfate molecules found there. The so-called exclusion zone (EZ) water in the glycocalyx releases protons preferentially into the circulation, generally leaving behind the deuterons, which strengthen the gel and the collagen matrices. Deficiencies in sulfation in the glycocalyx lead to weakening of the battery maintained by the gelled water, ultimately resulting in higher levels of deuterium circulating in the blood. It is possible although still speculative that proline-rich intrinsically disordered proteins (IDPs) fractionate deuterium out of the medium and sequester it in the “misfolded” oligomers and fibrils that are a feature of neurodegenerative diseases such as Alzheimer’s.
Is Deuterium Fractionation a Major Controlling Factor in Human Metabolism and Cancer? An Essential Role for Proline
https://www.preprints.org/manuscript/202406.1284/v1 -
Overall, a pattern emerges that suggests that the cells are able to somewhat independently control deuterium levels in the water in different compartments so as to optimize metabolic health. To a first approximation, it appears that the cell strategizes to maintain deupleted water in the major organelles, most especially the mitochondria, but also the endoplasmic reticulum (ER), the peroxisome, the lysosomes and the nucleus. In parallel, as we will argue later on, the cell likely sequesters deuterium in the collagen molecules and gelled water in the extracellular matrix, particularly in the bone [18]. Deuterium doping actually strengthens bone, whereas deuterium is toxic to the mitochondrial ATPase pumps, so such a strategy is consistent with metabolic needs.
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@NNight are you autistic ?
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@eduardo-crispino you're blocked.
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There's a gem in this thread.
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He has colloidal expertise. That's why he can fly.
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Can anyone link me to an example on twitter? I'd like to PCR test the participants.
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@ThinPicking said in Twitter fad fixating on Deuterium and carb seasonality? What's the deal?:
There's a gem in this thread.
You are too kind.
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Well, there is that too.
Is that cat still with you @dapose? My memory isn't photographic, but I remember a cat.
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@ThinPicking haha! Yes! He’s the best! Still kicking ass!
I’d post a pic of him but I can’t figure out how to upload pics on this forum. Other than my
Little profile gif. -
Excellent
That'll do.
