Stopped absorbing thyroxine....
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Hi Guys, has anyone experienced this?
i do everything right, empty stomach, hour away from food, it was working and just stopped.
Stopped gluten now for few days but doesn't seem anything is happening yet.
Tried a different brand, nothing too.
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@FitnessMikey said in Stopped absorbing thyroxine....:
I do everything right...
You think you do so but ...
What about the required nutriments for deiodinase enzymes? -
@LucH nutrients? Nothing changed i eat nutrient-dense foods as always.
first thing I thought its because magnesium sulphate gut flushes I was doing daily for constipations, stopped and nothing changed.
Then tried not expired thyroxine and nothing changed.
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@FitnessMikey said in Stopped absorbing thyroxine....:
Nothing changed i eat nutrient-dense foods as always.
--= I Se Mg are used up. Deiodinases are'nt efficient.
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Just taking T4 can have no effect as you need the liver to convert it to T3 (the active hormone). Eating more protein can help the liver to do its job.
You can try taking T3 and see if it has a metabolism boosting effect. A 1:3 ratio of T3:T4 is better than taking plain T4 or T3 since it prolongs the otherwise short lived effect of just T3.T4 can have a brain suppressive effect so do not increase the dosage too rapidly
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@PissBoy thanks.
The thing is that i need t4 as it alleviates symptoms for the most part, but its not going up in my serum after last test despite taking 50mcg and now 100mcg, nothing much change. i take some portk thyroid to raise my ft3.
No idea why it stopped raising my total t4 lvls for some months.
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@FitnessMikey Estrogen inhibits livers conversion of T4 to T3.
Just taking T4 can tank TSH, turning off your thyroid production. That combined with an ineffective T3 conversion can lead to worsened hypothyroidism and in severe cases an actual comatose state. 100mcg is quite a dose.When the liver is the main cause of hypothyroidism, your temperature (and especially the temperature of your nose, hands and feet) will fall when hungry, and will rise when you eat carbohydrates. If a hypothyroid person has a very slow pulse, and feels lethargic, it seems that there is little adrenalin; in this case, a feeding of carbohydrate is likely to increase both the pulse rate and the temperature, as the liver is permitted to form the active T3 hormone. - link
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@PissBoy conversion is one thing, but t4 stopped raising my total t4 in the blood. Which wasn't problem before.
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@FitnessMikey have you done a comprehensive thyroid panel?
Do you know your rT3 levels? -
@PissBoy I do it occasionally, and it seems to be elevated. However, it still doesn't explain why my total T4 won't raise from thyroxine; as I said before, I had no problem with that.
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@FitnessMikey I read your thread in the old forum. Your experiences are very similar to mine, with using thyroid.
Be mindful that it takes a much longer time to notice effects from T4, days, most often weeks.How much T3 are you taking? I believe you need to lower your T3.
T3 tanks TSH much more abruptly than T3 actually. Thatâs why Peaters who take a high ratio of T3:T4 often have low freeT4 in the blood. The T3 suppresses the TSH >> endogenous production of T4 halts and the amounts theyâre supplement ming exogenously are too low.For high absorption, you need to take T4 on empty stomach 4 hours away from food.
From my experience, high dose T4 feels good for a while, a few months, until it doesnât. Iâm at that point.
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@FitnessMikey said in Stopped absorbing thyroxine....:
conversion is one thing, but t4 stopped raising my total t4 in the blood. Which wasn't problem before.
I'll repeat it in another way.
Why a lack of functional deiodinase enzyme interferes with metabolism.
I often hear: âAfter experiencing significant success with a synthetic thyroid hormone supplement, I'm feeling out of sorts.â Why? => I donât understand⊠I haven't changed anything in my habits or my diet that could justify this discomfort!
Attempt at explanation
Deiodinases control local cellular and systemic thyroid hormone availability. The deiodinase enzymes are involved in activation and inactivation of thyroid hormones, thus modulating the availability when needed, in order to fine-tune the functions of the carburetor. (5-7)
Deiodinases allow tissues to customize either enhancing or decreasing the intracellular concentration of thyroid hormone at the single-cell level and independently of plasma.
5) Deiodinases control local cellular and systemic thyroid hormone availability
https://doi.org/10.1016/j.freeradbiomed.2022.09.024
Thyroid and deiodinase function depends on supply of the trace elements iodine, selenium and iron.Additional info:
Taking T3 and T4 synthetic supplement improves metabolism for a while
https://mirzoune-ciboulette.forumactif.org/t2108-english-corner-taking-t3-and-t4-synthetic-supplement-improves-metabolism-for-a-while#30193
Expressed differently:
If there is not an adequate supply of nutrients to optimize the functioning of the deiodinase enzymes DIO 1 DIO 2 and especially DIO 3, the improvement will be very often temporary / provisional.
Required nutrients (1) for immediate optimal function of the thyroid: I, Mg, Se, Zn and tyrosine.
*) Selenium is used up when there is HM toxicity or excess ROS.
Iodine is used up when there are allergy, immune problems, infection ...
Deficiency in selenium and iodine can negatively impact thyroid hormone metabolism, even when thyroid hormone supplementation is used. -
@GreekDemiGod naa borther, i should feed some improvement right away from 100mcg t4, I know historically. Its very strange that it stopped raising my hormones in my serum. maybe long term usage of gut flushing stuff did something to my small intestine and thus stopped absorbing t4. I want to try liquid t4 but cant find anything shipping to poland/uk.
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Since I never stopped eating the right foods, the only thing that comes to my mind is that it has something to do with gut health and not being absorbed in the small intestine.
It would be fantastic if someone went through something like this too and shared their experience.
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@FitnessMikey said in Stopped absorbing thyroxine....:
Since I never stopped eating the right foods,
Specify the exact amount of magnesium intake, and especially iodine and selenium.
Then, you deduct the amount "burned" by stress, carburetion and oxidation, not to mention inflammation or a virus that's been around recently.
Of course, with that, and a balanced dietary intake, but deficient in Se and Mg, like 80% of the population, you're on target/on the right track.
So, you won't lack what deiodinases need, as mentioned previously. You remember why, of course.
(irony, sorry; I couldn't help myself). -
@LucH sorry, i think im failing to understand that deiodinases enzymes are required somehow I'm simply absorption of exogenous enzymes. I did multiple test over the years for selenium and magnesium and they were good, not so much about the zinc though. Did you have similar problem to mine?
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The trace elements in your analysis are good. If you're taking a supplement with manganese in it, there's a problem: No Mn or Fe in the multivitamins (Fenton reaction).
Your phosphorus level is borderline high, but I guess it's not like this every day.
Ca/P 2.2/1
Maximum double for P if it's occasional.
If calcium comes from food, OK. Otherwise no need to be so high. Need to eat 1 slice Gouda cheese for K2 (interaction between Ca P K2 D3 Retinol and vitamin E + beta-carotene). However, it's still going to make P level higher. No need to eat more 2 x 80-120 g meat /d. (3-4.5 oz.) to limit the source of P. -
@FitnessMikey Itâs weird. After a couple weeks of trying to lower my dose and feeling worse. Today I took 100mcg T4 + 20 mcg T3 in the morning, 1hrs before eating . I definitely felt the metabolism boosting effect today.
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Have you tried taking less?
Sounds weird but it's something Roddy talked about. Taking small (1/8 of a tablet) doses, but I dont recall if it was about pure T3, might work with T4 too.
