Coffee dries out skin and eyes, like finasteride, dutasteride and accutane
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ah, I think I get it! you mean that beer was supposed to castrate me even more than tea polyphenols and coffee?)
surprisingly, beer increased my libido yesterday and I understand why!
Ray wrote about this, that estrogen can cause hypersexuality and it is true) -
@alex155 said in Coffee dries out skin and eyes, like finasteride, dutasteride and accutane:
you mean that beer was supposed to castrate me even more than tea polyphenols and coffee?)
No. I mean it "hydrated" you. This is a complex, circadian and behaviour dependant phenomenon. The meme of water bottles next to a body diagram is a nonsense depiction.
How you then act on that understanding can be simple. Get your head around it and you'll tolerate coffee etc.
surprisingly, beer increased my libido yesterday and I understand why!
Unsurprising to me given your current reaction to coffee. Cheers!
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@CrumblingCookie said in What's up with the EGCG health potion trending on RPF?:
Maybe someone with more dedicated brain activity to spare can look into that more profoundly.
@bot-mod said in What's up with the EGCG health potion trending on RPF?:
I'm far too busy.
@alex155 said in Coffee dries out skin and eyes, like finasteride, dutasteride and accutane:
another study about EGCG and other inhibitors, including caffeic acid.
Heisenberg.
God dammit. I'm coming back to this later.
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@alex155 What if you are simply deficient in Zinc?
A little learning is a dangerous thing ;
Drink deep, or taste not the Pierian spring :
There shallow draughts intoxicate the brain,
And drinking largely sobers us again.
~Alexander Pope, An Essay on Criticism -
@Kvirion I tried zinc, it also dries the skin, because it is an inhibitor of 5α-reductase
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@Kvirion https://pubmed.ncbi.nlm.nih.gov/33878855/
Conclusions: Based on our results, the combination of arginine and zinc tested in our study could represent a good therapeutic option for the treatment of AGA and TE and it might represent a valid alternative to finasteride.
but there is also this study: https://pubmed.ncbi.nlm.nih.gov/30772815/
Zinc is essential in the regulation of a variety of physiological and biochemical events in the organism. It plays a critical role in maintaining the cell membrane integrity, protein-carbohydrate-lipid metabolism, immune system, wound injury and in the regulation of a number of other biological processes associated with normal growth and development. Physiological and biochemical levels of many hormones are affected by zinc metabolism. Therefore, growth impairment, hypogonadism, and some endocrine diseases are associated with the deficiency of zinc. These effects of zinc are considered versatile. Zinc increases the synthesis of the growth hormone and its number of receptors; thus, it is an important mediator in the binding of this hormone to its receptor. Found in a large quantity in the pancreas tissue, zinc has a part in the regulation of the effect of insulin. Zinc is involved to much more thyroid hormone metabolism such as hormone synthesis, receptor activity, conversion of T4 to T3, and production of carrier proteins. The low levels of zinc and high levels of leptin in obese individuals point to a critical relationship between zinc and leptin. Zinc is related to enzyme activity to melatonin synthesis. Melatonin has regulatory activity for zinc absorption from gastrointestinal system. Zinc particularly affects the conversion of testosterone to dihydrotestosterone, as 5α-reductase that is involved in this conversion is a zinc-dependent enzyme. In consideration of these relations, zinc is accepted to play critical roles in the endocrine system. The aim of the current review is to draw attention to the effects of zinc on the endocrine system.
there is an opinion that zinc inhibits 5ap in high quantities, and increases it in small quantities, but I tried both methods, but the effect is the same - dry skin
I'm writing through Google Translate
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Can anyone explain this study? https://pubmed.ncbi.nlm.nih.gov/8279712/
neutralized zinc (zinc gluconate + arginine)
does arginine neutralize zinc? zinc gluconate is bad because arginine neutralizes zinc gluconate? I don't get it.
Abstract
Zinc has been implicated in steroid endocrinology of the prostate gland; and 5 alpha-dihydrotestosterone (DHT) is believed to express androgenic responses in the prostate. To note the effect of neutralized zinc (zinc gluconate + arginine) on the prostate, 50 sexually mature rats, weighing 325 +/- 20 g, were divided into five groups as follows: (1) control, (2) sham, (3) castrated, and injected intraprostatically with (4) 10 mg neutralized zinc, and (5) 20 mg neutralized zinc. Results indicated significant reduction (P < 0.05) of prostate weight, 5 alpha-reductase activity, and total protein and DNA concentrations in treated prostate tissue; no significant change in weight and histological structure of testes, epididymides, and seminal vesicles; and no significant effect on progeny and blood testosterone level of treated animals. These results suggest that direct application of neutralized zinc to the prostate offers a new modality for treatment of prostatitis without affecting spermatogenesis.
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@alex155
Zinc gluconate + arginine is a veterinarian castration product injected into the testisall 12 testes contained dark red, well-demarcated regions involving 25% to 100% of the testicular parenchyma (Figure 3). Histologically, these regions were characterized by severe, acute, coagulative necrosis with extensive acute hemorrhage. The inflammation and injury often extended beyond the testes into the tunics and epididymis; adjacent vessels showed evidence of vascular injury and thrombosis. - link
The zinc is an antiseptic like spermicide and the arginine, as a nitric oxide precursor facilitates the inflammation permanently damaging the testis.
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@PissBoy
Thank you very much for helping me figure this out! -
@alex155 Interesting research, thanks.
Have you also considered the importance of copper and its role in balancing zinc?
https://pmc.ncbi.nlm.nih.gov/articles/PMC4556990/
In the skin, copper is involved in the synthesis and stabilization of extracellular matrix skin proteins
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@Kvirion thank you very much! yes, I didn't think about copper, I need to try it
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I got it,
all these products are also strong aromatase inhibitors...
low DHT, plus low estrogen - makes you a real castrate! I
should reduce aspirin to at least one 100mg tablet every three days. By the way, UDCA also destroys all estrogen, and I've been taking it for 3 years -
A alex155 referenced this topic on
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By the way, zinc bisglycinate, unlike the sulfate and citrate forms, does not cause dry skin, but no more than 25 mg per day.
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@PissBoy Very interesting.
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At least coffee can be multifaceted-ly beneficial, when taken in the right amounts and with cream and sugar.
Fina steride seems to be completely destructive. -
Coffee helps with:
Fighting Melanoma
Oral health
Keep ing Cortisol down
Liver health
Protecting against Senility
Maintain ing DNA integrity
Prevent ingTinnitus
Cancer, particularly liver cancerhttps://lowtoxinforum.com/search/2631402/?q=Coffee&c[title_only]=1&c[users]=Haidut&o=relevance
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This is interesting but I think it can be helpful to take breaks from coffee. Like, try to go to sleep and just wake up naturally on time, have the energy to sleep deeply. Not saying it's easy I just feel less reliant on coffee though. It helps, but I used to rely on it very heavily.
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good luck with your castration, Chuckie, with high doses of B6 and zinc:
https://pubmed.ncbi.nlm.nih.gov/3207614/
Abstract
The effects of zinc sulphate and azelaic acid on 5 alpha-reductase activity in human skin were studied using an in vitro assay with 1,2[3H]-testosterone as substrate. When added at concentrations of 3 or 9 mmol/l, zinc was a potent inhibitor of 5 alpha-reductase activity. At high concentrations, zinc could completely inhibit the enzyme activity. Azelaic acid was also a potent inhibitor of 5 alpha-reductase; inhibition was detectable at concentrations as low as 0.2 mmol/l and was complete at 3 mmol/l. An additive effect of the two inhibitors was observed. Vitamin B6 potentiated the inhibitory effect of zinc, but not of azelaic acid, suggesting that two different mechanisms are involved. When the three substances were added together at very low concentrations which had been shown to be ineffective alone, 90% inhibition of 5 alpha-reductase activity was obtained. If this inhibition is confirmed in vivo, zinc sulphate combined with azelaic acid could be an effective agent in the treatment of androgen related pathology of human skin.
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@alex155
effects could be different from adding other components of the formula. there's people with testosterone increased from HG7
but that's an interesting study yeah -
@teamfortress too many 5-ar inhibitors bro...
https://pubmed.ncbi.nlm.nih.gov/11380153/
Abstract
Hamster flank organ growth, as measured by an increase in the area of the pigmented macule, is androgen-dependent. When flank organs of a castrated hamster are treated topically with testosterone, the flank organ becomes larger and darker. Since this growth is known to be dependent on the intracellular active androgen, 5alpha-dihydrotestosterone (DHT), inhibitors of 5alpha-reductase which converts testosterone to DHT can inhibit the growth of the flank organ. Certain unsaturated aliphatic fatty acids, such as gamma-linolenic acid and myristoleic acid, as well as other natural compounds, including alizarin and curcumin, are 5alpha-reductase inhibitors and inhibited flank organ growth. Green tea catechins, including (-)-epicatechin-3-gallate, and (-)-epigallo-catechin-3-gallate (EGCG) are also 5alpha-reductase inhibitors and inhibited flank organ growth. However, (-)-epicatechin and (-)-epigallocatechin, which are not 5alpha-reductase inhibitors, also inhibited flank organ growth. EGCG also inhibited DHT-dependent growth of flank organs. These catechins, therefore, may act by a mechanism other than inhibition of 5alpha-reductase. The effect of EGCG and other compounds was localized at the site of application; they did not affect the growth of the contralateral flank organ in the same animal. Since these compounds do not appear to exhibit systemic effects, they may be potentially useful for treatment of androgen-dependent skin disorders.
