Inosine directly binds and blocks the endotoxin/LPS receptor (TLR4)
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Inosine also converts to uric acid quite readily which is why it was abandoned as an ergogenic in the 80's
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Its abandonment due to uric acid was most likely part of trickery science: the stuff controllers and such set up to create sleight of hand. In the old forum around I think it was 2015 or 2016, I had mentioned I suspected gout to be not of a uric acid problem but of a metabolic one. One induced by pufa consumption. Fast forward to 2021, and Wie-Zheng Zhang established in "Why Does Hyperuricemia Not Necessarily Induce Gout" that inflammation was the true driver. Now I think even some of these good researchers still have a ways to go to form a whole-picture idea, but researchers and studies like this are a step in the right direction. Rather than the mechanical "uric acid goes up, and gout happens," it is now being understood gout is an afflicted immune problem (take note I do NOT say autoimmune; that idea is utter crap), based on systemic inflammation; even calling it a type of arthritis. Uric acid being most likely a compensatory and defensive reaction. I even said in that old thread on the old forum uric acid is hijacked. These shallow, mechanistic correlations are made to say good things are bad. SUCH as inosine. The immediate correlation to increased uric acid also equates to "inosine bad."
Incidentally, one of the most important pieces of evidence is that only about 36% of gout patients have high levels of uric acid.
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The only two folks I’ve know that have serious gout are heavy drinkers. And old. And pretty sharp minds too. Like excitatory Adrenalin or something. No science here just anecdotal bs so I can fallow others thoughts on this thread.
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You take inosine WITH a xanthine oxidoreductase inhibitor such as apigenin —you raise ATP and raise your metabolic rate…there are numerous clinical trials with inosine + feboxostat but there is no need for a Big Pharma drug to do this yourself.
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@bio3nergetic said in Inosine directly binds and blocks the endotoxin/LPS receptor (TLR4):
most likely part of trickery science: the stuff controllers and such set up to create sleight of hand
Those pesky evil scientists.
Now I think even some of these good researchers still have a ways to go to form a whole-picture idea, but researchers and studies like this are a step in the right direction.
It could be viewed as a disorder of fluid turnover. If there's an issue with exchange over the synovial membrane or those ahead of it, that could explain discrepancies in uricemia markers.
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@dapose This is a good insight into the inflammation variable as what heavy drinkers exhibit. When I used do nutritional consulting, a couple of clients had gout that cleared up with diet change, namely the pufa exposure.
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Fascinating. Have you experimented with it yourself or know of people who have dialed in the dosages?
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@jamezb46 said in Inosine directly binds and blocks the endotoxin/LPS receptor (TLR4):
Fascinating. Have you experimented with it yourself or know of people who have dialed in the dosages?
Yes. 500mg - 1000mg twice a day of inosine. I’ve used 100mg or so of apigenin. You can also use a single drop of Eugenol instead.
Try it. It works very well. I’m doing a different experiment now, but I’ll come back to this soon.
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Thanks so much for responding. When you mention increased ATP and increased metabolic rate what kind of phenomenological effects does that manifest as? Increased temp? pulse? more sharp cognition? less fatigue? less lactic acid feeling in muscles?
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@jamezb46 yes all that. Just remarkable clarity. There are a number of clinical trials for this approach. It can probably reverse autism.
